CoMetro CP Series High-Pressure Temperature-Controlled Piston Pump

Overview

The CoMetro CP Series High-Pressure Temperature-Controlled Piston Pump is an engineered solution for applications demanding simultaneous high-pressure delivery, precise flow regulation, and active thermal management of process fluids. Built upon a dual-servo-controlled micro-stepping motor architecture and a dual-piston reciprocating mechanism, the pump operates on positive displacement principles—ensuring volumetric accuracy independent of fluid viscosity or backpressure fluctuations up to 42 MPa (6000 psi). Unlike passive heated syringe pumps or non-temperature-stabilized HPLC pumps, the CP Series integrates a closed-loop PID temperature controller directly into the fluid path assembly, maintaining thermal homogeneity across the inlet manifold, pump head cavity, and outlet line. This design eliminates thermal lag and minimizes density-driven flow deviation—critical when handling low-viscosity solvents (e.g., acetonitrile, THF) or thermally sensitive reagents (e.g., organometallic catalysts, enzyme solutions) in continuous-flow synthesis or kinetic studies.

Key Features

• Dual-piston architecture with active pulse-dampening and auto-refill synchronization—reducing pulsation amplitude to <1.5% RSD at full-scale flow
• Integrated 316L stainless steel thermostatic block with distributed heating elements and real-time Pt100 sensor feedback—enabling ±0.5°C temperature stability over 10–120°C operating range
• Modular flow calibration: three selectable ranges (0.001–5 mL/min, 0.001–10 mL/min, 0.01–50 mL/min) with factory-traceable gravimetric verification per ISO/IEC 17025
• Front-panel LED interface with dual-line display for simultaneous monitoring of setpoint/actual flow rate and temperature; optional PC control via RS232 with ASCII command protocol
• Onboard analog I/O (0–5 V, 4–20 mA) and frequency input for synchronized operation within automated reactor systems or PLC-controlled pilot plants
• Built-in pressure relief valve and programmable self-cleaning cycle—minimizing maintenance downtime during long-duration runs with particulate-laden or polymerizable media

Sample Compatibility & Compliance

The CP Series accommodates a broad spectrum of chemically aggressive and biologically relevant fluids—including chlorinated hydrocarbons, strong acids (e.g., concentrated HCl, HNO₃), basic aqueous solutions (pH 1–14), and protein-containing buffers—thanks to its fully 316L stainless steel wetted path and chemically inert PTFE/graphite composite seals. It complies with material compatibility standards outlined in ASTM F2028 (for elastomer selection) and meets mechanical safety requirements per EN 61000-6-2 (EMC immunity). For regulated environments, the pump supports audit-ready operation: all parameter changes (flow, temp, hold time) are timestamped and logged internally; optional firmware enables 21 CFR Part 11-compliant electronic signatures and user-level access control when paired with validated LIMS or ELN platforms.

Software & Data Management

The CP Series supports both standalone and networked operation. Its embedded firmware stores up to 100 method profiles with programmable ramp/hold sequences for flow and temperature. Raw operational data—including real-time pressure transducer output, motor step count, and thermal gradient logs—is exportable as CSV via USB or RS232. CoMetro’s optional PumpControl Suite (v3.2+) provides GxP-aligned features: electronic signature capture, change history with reason-for-change fields, and automated report generation compliant with ISO/IEC 17025 clause 7.8. All software modules undergo annual cybersecurity review per NIST SP 800-53 Rev. 5 controls.

Applications

• Continuous-flow chemical synthesis requiring precise stoichiometric delivery under elevated pressure and controlled thermal gradients (e.g., nitration, hydrogenation, photochemical cyclization)
• High-temperature liquid chromatography (HTLC) and supercritical fluid chromatography (SFC) mobile phase delivery where thermal expansion must be compensated
• Calibration and verification of inline densitometers, viscometers, or FTIR flow cells operating in closed-loop recirculation mode
• Microreactor feeding in academic and industrial R&D labs—particularly for kinetics modeling where residence time distribution depends on thermal consistency
• Pharmaceutical process analytical technology (PAT) deployments, including real-time API crystallization control and solvent exchange in nanoparticle formulation

FAQ

What is the maximum allowable inlet fluid temperature?
The pump is rated for continuous operation with fluids preheated up to 120°C at the inlet port; however, sustained exposure above 90°C requires optional high-temp seal kits (order code: CP-HTSK-01).
Can the CP Series be integrated into a multi-pump gradient system?
Yes—via RS232 daisy-chaining or external PLC coordination using analog synchronization signals; flow cross-talk is minimized by independent PID loops per unit.
Is the temperature control applied only to the pump head—or does it extend to tubing connections?
Thermal management covers the entire primary fluid path: inlet ferrule, pump housing, plunger chamber, and outlet manifold; external tubing remains unheated unless coupled with optional trace-heated lines.
How often does the system require recalibration?
Annual calibration is recommended per ISO/IEC 17025; however, built-in flow verification routines allow daily user checks using certified volumetric flasks and stopwatch timing.
Does the pump support solvent compatibility documentation for regulatory submissions?
Yes—CoMetro provides a Material Compatibility Matrix (MCM-CP-2024) listing >120 solvents with degradation thresholds, permeation rates, and seal life estimates under defined T/P conditions.