DHS NX-2R Benchtop High-Speed Refrigerated Centrifuge

Overview

The DHS NX-2R is a high-performance benchtop refrigerated centrifuge engineered for precision separation of biological macromolecules—including proteins, nucleic acids, subcellular organelles, and viral particles—in research, clinical diagnostics, and quality control laboratories. It operates on the principle of sedimentation under controlled gravitational force (RCF), where differential particle migration rates in a rotating field enable size- and density-based fractionation. Designed for consistent thermal management during high-speed operation, the NX-2R integrates an imported eco-friendly refrigeration system capable of maintaining sample temperatures at ≤4 °C even at maximum rotational speed (18,500 rpm), ensuring integrity of thermolabile biomolecules. Its compact footprint (360 × 330 × 630 mm) and 46 kg mass provide stability without compromising bench space—making it ideal for shared core facilities and regulated environments where spatial efficiency and operational reliability are critical.

Key Features

• Refrigeration system with environmentally compliant refrigerant, achieving stable temperature control from –20 °C to 40 °C in 1 °C increments; maintains ≤4 °C sample temperature at full speed via optimized airflow and compressor duty cycling
• Low-noise mechanical architecture incorporating vibration-damping suspension, balanced rotor drive assembly, and acoustic insulation—measured noise level ≤65 dB(A) at 1 m distance
• Full-metal reinforced chassis and 3.2 mm thick stainless-steel rotor chamber enhance structural rigidity and resistance to corrosion and mechanical fatigue
• Electronic safety door lock with interlock verification prevents operation unless lid is fully closed and sealed; automatically halts rotation if door opens mid-run
• Automatic rotor identification via embedded RFID tags or optical encoding—ensures correct RCF calculation, speed limitation, and protocol validation per rotor geometry
• Overtemperature protection circuitry triggers immediate shutdown if rotor chamber exceeds preset thermal threshold, safeguarding both samples and instrument longevity
• Intuitive membrane keypad interface with real-time display of speed, RCF, time remaining, temperature, and error codes; supports programmable storage of up to 10 user-defined protocols

Sample Compatibility & Compliance

The NX-2R accommodates a broad range of tube formats—including 0.2 mL PCR strips, 1.5/2.0 mL microcentrifuge tubes, 5/15/50 mL conical tubes, and 100 mL bottles—via interchangeable angular rotors (e.g., 6 × 50 mL, 30 × 1.5/2.0 mL, 8 × 8 PCR strips). All rotors are certified to ISO 15197:2013-compliant balancing tolerances and undergo dynamic balancing per ISO 21501-4. The system meets IEC 61010-1:2010 safety requirements for laboratory electrical equipment and complies with electromagnetic compatibility standards EN 61326-1. While not pre-certified for FDA 21 CFR Part 11, its audit-ready event log (including start/stop timestamps, rotor ID, speed, temperature, and fault codes) supports GLP/GMP-aligned documentation practices when integrated into validated workflows.

Software & Data Management

The NX-2R operates as a standalone instrument with no proprietary PC software dependency. All operational parameters and run history are stored locally in non-volatile memory with timestamped entries. Event logs retain the last 100 cycles—including rotor type, setpoints, actual performance data, and any triggered safety interventions—for traceability and troubleshooting. Optional RS-232 or USB-to-serial interfaces (available upon request) enable integration with LIMS or lab automation platforms for centralized monitoring and electronic record retention. Data export is supported in CSV format via removable USB flash drive, facilitating compliance with internal SOPs requiring raw parameter archiving.

Applications

• Purification of plasmid DNA, genomic DNA, and RNA using silica-membrane spin columns (compatible with 18 × 2.0 mL Spincolumn rotor)
• Clarification of bacterial lysates and mammalian cell supernatants prior to chromatography or electrophoresis
• Isolation of mitochondria, nuclei, and synaptic vesicles via differential centrifugation protocols (0.2–26,000 × g range)
• Concentration of low-abundance extracellular vesicles and exosomes from biofluids (plasma, serum, CSF)
• Preparative pelleting of virus particles for vaccine development or structural studies
• Routine QC testing of biopharmaceutical intermediates including monoclonal antibody aggregates and host-cell protein residuals

FAQ

What is the minimum achievable temperature at maximum speed?
At 18,500 rpm, the NX-2R maintains rotor chamber temperature at ≤4 °C when set to 4 °C; the –20 °C setting is achievable at speeds ≤12,000 rpm.
Does the NX-2R support fixed-angle and swinging-bucket rotors interchangeably?
The NX-2R is configured exclusively for angular rotors; swinging-bucket configurations are not supported due to mechanical and thermal design constraints.
Is rotor calibration required before first use?
No—each rotor ships with factory-calibrated inertia and geometry parameters; automatic recognition eliminates manual input.
Can the centrifuge be operated in continuous mode after reaching set speed?
Yes—“continuous” timer mode allows indefinite operation at stabilized speed and temperature until manually stopped.
What safety certifications does the NX-2R hold?
It conforms to IEC 61010-1:2010 (Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use) and EN 61326-1:2013 (EMC for Laboratory Instruments).