English Product Name

Overview

The Zhonghui ZWY-111G is a high-capacity, tall-profile constant-temperature orbital shaker engineered for scalable bioprocessing applications requiring precise thermal control and robust mechanical stability. Designed around a true orbital motion principle—where the platform rotates in a circular path with a fixed 70 mm diameter—the system ensures uniform suspension of microbial cultures, mammalian cells, and enzymatic reaction mixtures without shear-induced damage typical of reciprocating or eccentric agitation. Its enlarged chamber volume (237 L) and vertical clearance (455 mm internal height) accommodate up to six 5-L Erlenmeyer flasks simultaneously, making it suitable for pilot-scale fermentation, seed train expansion, and high-yield protein expression workflows. The unit employs forced-air convection with PID-controlled heating and passive thermal management (no active refrigeration), optimized for stable operation between ambient +5 °C and 60 °C—covering standard incubation ranges for E. coli, yeast, insect, and CHO cell lines. All thermal and motion parameters are governed by an embedded microprocessor with environmental scanning logic, ensuring reproducible setpoint tracking under variable load and ambient conditions.

Key Features

• 70 mm orbital diameter drive mechanism delivering gentle yet effective mixing for oxygen-sensitive and shear-sensitive cultures
• One-piece reinforced stainless-steel inner chamber with electrostatically sprayed steel exterior and tempered glass viewing window for real-time process monitoring
• PID-based temperature controller with ±0.1 °C resolution, ≤±0.5 °C stability at 37 °C, and ≤±1 °C uniformity across full shelf area
• Brushless AC induction motor with constant-torque output across 30–150 rpm range; speed accuracy maintained within ±1 rpm
• Intelligent safety architecture: over-temperature cutoff, motor overheat protection, power-fail recovery, and programmable alarm escalation (audible + visual)
• Full-parameter encryption lockout prevents unauthorized modification of critical operating conditions during GLP-compliant runs
• Extended timer function (0–500 h) with auto-shutdown and end-of-cycle alert; retains last-used settings after power interruption
• Smooth acceleration profile minimizes flask slippage and media splashing during startup and speed transitions

Sample Compatibility & Compliance

The ZWY-111G supports standardized laboratory glassware and disposable bioreactor vessels ranging from 100 mL test tubes to 5 L baffled flasks. Its 770 × 500 mm stainless-steel shelf accepts universal clamping systems—including spring-loaded, rubber-grip, and magnetic platforms—for secure retention under high-speed operation. The unit meets IEC 61010-1 safety requirements for laboratory equipment and complies with electromagnetic compatibility standards EN 61326-1. While not intrinsically rated for hazardous environments, its construction adheres to ISO 13485-aligned manufacturing practices. For regulated environments, the device supports audit-ready documentation through external data logging (via RS-485 or optional USB interface) and is compatible with 21 CFR Part 11–compliant third-party software for electronic record integrity and user access control.

Software & Data Management

The ZWY-111G operates via an integrated LCD interface with backlighting for low-light lab environments. All setpoints—including temperature, speed, and timer—are displayed concurrently with real-time measured values. Though the base configuration lacks onboard data storage, it features analog and digital outputs (0–5 V / 4–20 mA and Modbus RTU) enabling integration into centralized SCADA or LIMS platforms. Optional firmware upgrades provide CSV export capability via USB flash drive, supporting traceability for QA/QC batch records. When paired with Zhonghui’s ZH-Link PC software (v3.2+), users gain access to trend visualization, multi-unit synchronization, deviation alerts, and PDF report generation—all structured to align with internal SOPs and external inspection readiness (e.g., FDA pre-approval inspections, ISO 9001 surveillance audits).

Applications

This shaker serves as a core platform in academic research labs, contract development and manufacturing organizations (CDMOs), and pharmaceutical quality control units. Typical use cases include aerobic bacterial cultivation (Bacillus, Pseudomonas), recombinant protein expression in shake-flask bioreactors, mycelial growth optimization for antibiotic screening, hybridoma culture expansion prior to bioreactor inoculation, and enzyme kinetics assays requiring sustained agitation at physiological temperatures. Its thermal consistency and mechanical repeatability make it suitable for method validation studies referenced in USP , EP 2.6.27, and ISO 11133. In food microbiology, it supports AOAC-certified enrichment protocols for Listeria and Salmonella; in environmental testing, it enables EPA Method 1681-compliant BOD bottle agitation.

FAQ

Does the ZWY-111G support active cooling below ambient temperature?

No. This model provides only heating and passive thermal regulation. For sub-ambient operation, consider the ZWY-111GL series with integrated thermoelectric cooling.

Is the shaking platform removable for cleaning or customization?

Yes—the stainless-steel shelf is secured with four M6 fasteners and can be detached without tools for autoclaving or replacement with custom fixtures.

Can the unit be validated for GMP production use?

While not supplied with IQ/OQ documentation out-of-box, the ZWY-111G’s deterministic control architecture, parameter lockout, and analog/digital I/O enable full qualification per ASTM E2500 and Annex 15 guidelines when supported by vendor-supplied DQ templates and calibration certificates.

What is the maximum flask fill volume recommended at 150 rpm?

For optimal oxygen transfer and minimal splashing, maintain ≤70% working volume—e.g., 3.5 L in a 5-L flask—especially above 100 rpm.

Are spare parts and service support available outside mainland China?

Yes. Zhonghui maintains authorized service partners in Germany, Singapore, and the United States, with lead times for critical components (motor assemblies, PID boards, display modules) typically under 12 business days.