Hanbon NS9001S Simulated Moving Bed Chromatography System
| Brand | Hanbon |
|---|---|
| Origin | Imported |
| Manufacturer Type | Manufacturer |
| Model | NS9001S |
| Application Level | Laboratory-Scale |
| Instrument Type | Medium-to-Low Pressure Preparative Liquid Chromatography |
| Flow Rate Range | 0–99.99 mL/min |
| Flow Accuracy | ±0.5% |
| Flow Precision (RSD) | ≤0.1% |
| Maximum Operating Pressure | 1 MPa |
| Wavelength Range | ±1 nm |
| Wavelength Repeatability | ±0.2 nm |
| Baseline Noise | 0.5 × 10⁻⁵ AU |
| Data Acquisition Frequency | 50 Hz |
Overview
The Hanbon NS9001S Simulated Moving Bed (SMB) Chromatography System is a laboratory-scale, medium-to-low pressure preparative chromatographic platform engineered for continuous, high-efficiency chiral or enantiomeric separation of fine chemicals, pharmaceutical intermediates, natural products, and bioactive compounds. Unlike conventional batch chromatography—where separation occurs in discrete cycles—the NS9001S implements SMB technology based on the principle of counter-current adsorption dynamics. By periodically switching inlet/outlet ports across an array of interconnected chromatographic columns (configurable from 1 to 12), the system emulates continuous countercurrent movement of the solid-phase adsorbent relative to the liquid-phase feed stream. This results in thermodynamically favorable mass transfer, enabling higher productivity, improved resolution (typically >0.9 vs. ~0.5 for single-column batch mode), enhanced product recovery (>95%), and significantly reduced solvent and stationary phase consumption—up to 60% and 50% lower, respectively, compared to equivalent single-column operations.
Key Features
- Modular column architecture supporting 1–12 column configurations for flexible operation modes: single-column batch, sequential batch, true SMB, and supercritical SMB (SSMB)
- High-precision dual-piston pump system with flow accuracy of ±0.5% and repeatability ≤0.1% RSD across the full 0–99.99 mL/min range
- Robust pressure-rated manifold design with maximum operating pressure of 1 MPa (10 bar), compatible with silica-, polymer-, and chiral stationary phases
- UV-Vis detector featuring wavelength accuracy of ±1 nm and repeatability of ±0.2 nm, baseline noise <0.5 × 10⁻⁵ AU at 254 nm, and real-time data acquisition at 50 Hz
- Low-dead-volume valve manifold with chemically resistant PEEK and stainless-steel wetted parts to minimize band broadening and cross-contamination
- Critical components sourced from globally recognized industrial suppliers—including precision solenoid valves, pressure transducers, and flow sensors—to ensure long-term operational stability and serviceability
Sample Compatibility & Compliance
The NS9001S is validated for use with common preparative-grade mobile phases (e.g., hexane/isopropanol, ethanol/water, acetonitrile/buffer systems) and standard chromatographic media (e.g., Chiralpak®, Lux®, Cellucoat®, silica gels). It supports sample loading volumes from milligram to multi-gram scale per cycle, accommodating both polar and nonpolar analytes. The system conforms to fundamental principles outlined in ICH Q5A(R2), USP , and ISO 17025 for analytical method development and process validation. Full DQ/IQ/OQ/PQ documentation packages are provided, including traceable calibration records, alarm log templates, and deviation handling procedures aligned with GLP and GMP expectations.
Software & Data Management
Control and monitoring are executed via a validated SCADA-based software platform built on Siemens SIMATIC WinCC or GE Digital iFIX architecture. The interface provides intuitive graphical configuration of switching sequences, real-time visualization of concentration profiles, automatic fraction collection triggers, and integrated audit trail functionality compliant with FDA 21 CFR Part 11 requirements—including electronic signatures, user access tiers, and immutable event logging. All raw chromatograms, method parameters, and system status logs are stored in standardized .CDF or .HDF5 format, enabling seamless integration with LIMS and enterprise data analytics platforms.
Applications
- Chiral resolution of racemic APIs (e.g., β-blockers, NSAIDs, antivirals) under regulatory-compliant development workflows
- Continuous purification of monoclonal antibody fragments and synthetic peptides
- Separation of structurally similar isomers in natural product isolation (e.g., flavonoids, terpenes, alkaloids)
- Process intensification studies for tech-transfer from lab to pilot scale
- Method scouting and optimization for downstream continuous manufacturing initiatives
FAQ
What column configurations does the NS9001S support?
It supports 1–12 column arrangements, enabling operation in single-column batch, sequential batch, classical SMB, and SSMB modes.
Is the system suitable for GMP manufacturing environments?
While designed for laboratory-scale development and pilot studies, its DQ/IQ/OQ/PQ documentation, 21 CFR Part 11–compliant software, and material traceability make it suitable for early-phase GMP process validation.
Can the NS9001S be integrated with existing process control infrastructure?
Yes—it features OPC UA and Modbus TCP communication protocols, allowing bidirectional integration with DCS, MES, or third-party automation systems.
What maintenance intervals are recommended for critical fluidic components?
Pump seals and check valves are rated for ≥6,000 hours of continuous operation; UV lamp replacement is advised every 2,000 hours; annual recalibration of flow and pressure sensors is recommended.
Does Hanbon provide method development support?
Yes—application engineers offer remote and on-site assistance for SMB cycle time optimization, zone flow ratio tuning, and stationary phase selection based on isotherm modeling and frontal analysis data.
