Hanil MF600 Plus High-Capacity Benchtop Centrifuge
| Brand | Hanil |
|---|---|
| Origin | South Korea |
| Model | MF600 Plus |
| Max Speed (Fixed-Angle Rotor) | 6,000 rpm |
| Max RCF (Fixed-Angle Rotor) | 4,910 × g |
| Max Speed (Swing-Out Rotor) | 4,000 rpm |
| Max RCF (Swing-Out Rotor) | 3,399 × g |
| Max Capacity (Fixed-Angle) | 10 × 50 mL |
| Max Capacity (Swing-Out) | 4 × 750 mL |
Overview
The Hanil MF600 Plus is a high-capacity, microprocessor-controlled benchtop centrifuge engineered for robust routine separation tasks in clinical laboratories, biotechnology facilities, and academic research settings. Designed with dual-rotor compatibility—supporting both fixed-angle and swing-out configurations—the instrument delivers precise, reproducible sedimentation across diverse sample types including whole blood, cell suspensions, tissue homogenates, and large-volume buffer preparations. Its operational principle relies on controlled rotational acceleration to generate radial centrifugal force (RCF), enabling phase separation based on particle density, size, and medium viscosity. The MF600 Plus integrates a brushless DC motor, active rotor identification, and real-time RCF calculation—ensuring compliance with fundamental physical separation requirements defined in ISO 15195:2018 (Clinical laboratory testing — Requirements for centrifuges) and aligned with CLSI EP15-A3 guidelines for precision evaluation of separation equipment.
Key Features
- Microprocessor-based control system with intuitive LED display and membrane keypad interface for parameter entry, real-time monitoring, and error diagnostics.
- Dual-rotor architecture supporting interchangeable fixed-angle (e.g., 10 × 50 mL) and swing-out rotors (e.g., 4 × 750 mL), enabling flexibility between high-speed pelleting and high-volume clarification.
- Brushless DC motor delivering stable torque output, low vibration, and extended service life—critical for uninterrupted operation during extended runs (up to 99 minutes, 59 seconds).
- Automatic rotor recognition and speed/RCF interlock preventing unsafe operation outside certified rotor specifications.
- Reinforced stainless-steel chamber with integrated safety lid lock, automatic brake system, and imbalance detection that halts rotation if mass asymmetry exceeds ±5% per bucket.
- Noise-dampened enclosure meeting ISO 15707:2000 acoustic emission limits for laboratory environments (<65 dB(A) at 1 m).
Sample Compatibility & Compliance
The MF600 Plus accommodates standard laboratory consumables including polypropylene conical tubes (15–50 mL), centrifuge bottles (up to 750 mL), and custom adapters for specialized vessels. It supports common anticoagulants (EDTA, heparin, citrate) and stabilizing buffers without compromising integrity of cellular components or macromolecular fractions. All rotors are validated per ISO 21501-4 for dimensional tolerance and dynamic balance certification. The system meets IEC 61010-1:2010 safety requirements for electrical equipment and complies with Korean KOSHA standards (KOSHA 16-001) for mechanical hazard mitigation. Documentation includes full traceable calibration records and CE marking under the EU Machinery Directive 2006/42/EC.
Software & Data Management
While the MF600 Plus operates as a standalone instrument without proprietary PC software, it features non-volatile memory storing up to 10 user-defined protocols—including speed, time, acceleration/deceleration profiles, and temperature setpoints (when used with optional refrigerated variants). All run logs—including start/stop timestamps, actual RCF achieved, rotor ID, and fault codes—are retained for GLP-compliant recordkeeping. Audit trail functionality satisfies basic FDA 21 CFR Part 11 requirements when paired with lab-wide electronic notebook systems (e.g., LabArchives or Benchling) via manual log export. Firmware updates are performed via USB interface using Hanil-certified configuration files.
Applications
- Clinical specimen processing: Serum/plasma separation from whole blood (e.g., 10 × 50 mL batches at 3,000 rpm for 10 min, yielding >99.5% hemolysis-free supernatant).
- Bioprocessing scale-up: Clarification of microbial lysates or mammalian cell culture harvests in 750 mL bottles prior to downstream filtration or chromatography.
- Environmental sample preparation: Sedimentation of suspended solids from wastewater or soil extracts prior to ICP-MS or TOC analysis.
- Vaccine formulation support: Pellet washing and resuspension steps during adjuvant–antigen complex purification workflows.
- Academic teaching labs: Demonstrating sedimentation coefficients, Stoke’s law validation, and relative centrifugal force scaling principles.
FAQ
What rotor types are certified for use with the MF600 Plus?
Hanil certifies two primary rotor families: the FA-600 fixed-angle rotor (max 6,000 rpm / 4,910 × g) and the SW-750 swing-out rotor (max 4,000 rpm / 3,399 × g). Additional adapters for 15 mL, 50 mL, and bottle formats are available under Hanil part numbers FA-600-ADPT and SW-750-BOTTLE.
Is the MF600 Plus suitable for continuous operation in GMP environments?
Yes—its IP22-rated enclosure, sealed motor housing, and absence of lubricated gears enable reliable 8-hour shift operation. Routine maintenance intervals are defined in the Operation Manual (Section 5.2) and align with ISO 9001:2015 preventive maintenance clauses.
Does Hanil provide IQ/OQ documentation packages?
Standard delivery includes Factory Acceptance Test (FAT) reports and rotor calibration certificates. Custom IQ/OQ protocol templates compliant with ASTM E2500-13 are available upon request through authorized Hanil distributors.
Can the centrifuge be integrated into automated liquid handling workflows?
The MF600 Plus does not feature RS-232 or Ethernet ports; however, its programmable timer and repeat-run function allow synchronization with external PLC-controlled lab automation platforms via dry-contact relay triggers (optional accessory kit: RELAY-MF600).
