Hanuo HNDK200-2 Dry-Block Nitrogen Evaporator

Overview

The Hanuo HNDK200-2 is a dual-module dry-block nitrogen evaporator engineered for high-throughput, inert-atmosphere sample concentration in analytical laboratories. It operates on the principle of controlled nitrogen gas impingement over heated sample surfaces—accelerating solvent evaporation while minimizing oxidative degradation, thermal decomposition, or analyte loss. Unlike rotary evaporation, which processes samples sequentially under vacuum, the HNDK200-2 enables parallel processing of up to 24 samples under precise thermal and gaseous conditions. Its dry-block architecture eliminates water bath maintenance, cross-contamination risk, and temperature gradient inconsistencies associated with liquid-based heating systems. Designed for integration into regulated workflows—including those aligned with ISO/IEC 17025, USP , and GLP-compliant sample preparation protocols—the instrument delivers reproducible concentration outcomes across diverse matrices encountered in pharmaceutical QC, environmental residue analysis, clinical toxicology, and omics sample prep.

Key Features

• Dual independent heating modules (2 × 95.5 × 76.5 × 50 mm blocks), each programmable with discrete temperature setpoints and timers
• Adjustable gas manifold with 12 individually controllable gas channels—enabling selective nitrogen delivery to active positions and reducing gas consumption by up to 50% versus fixed-flow systems
• Height-adjustable gas needle assembly (standard 150 mm needles), compatible with variable liquid levels and tube geometries; optimized for minimal vortexing and splashing during final-stage evaporation
• Real-time digital display showing current temperature (0.1°C resolution), countdown timer (99 h 59 min max), and system status indicators
• Integrated safety architecture: dual-limit over-temperature cutoff, automatic fault diagnostics with visual/audible alerts, and fail-safe shutdown upon sensor anomaly or power fluctuation
• Ventilation-ready mechanical design—fully enclosable within standard fume hoods for safe handling of volatile, toxic, or low-boiling solvents (e.g., chloroform, hexane, ethyl acetate)
• Modular block interchangeability supporting standardized tube formats: 0.2 mL PCR strips, 0.5/1.5/2.0 mL microcentrifuge tubes, 96-well microplates, and custom diameters from 6 mm to 40 mm

Sample Compatibility & Compliance

The HNDK200-2 accommodates a broad spectrum of sample containers without requiring adapter kits—leveraging precisely machined, thermally uniform aluminum blocks with optimized thermal conductivity. Each block supports up to 24 × 16 mm tubes or alternative configurations (e.g., 96 × 0.2 mL wells, 6 × 40 mm vials) via field-replaceable modules. The system complies with fundamental electrical safety standards (IEC 61010-1) and is suitable for use in environments governed by ISO 17025 accreditation requirements, where documented traceability of temperature calibration and gas flow validation is mandatory. While not inherently 21 CFR Part 11 compliant, its deterministic timer logging, non-volatile parameter storage, and absence of user-modifiable firmware enable audit-ready operation when paired with laboratory information management systems (LIMS) that enforce electronic signature and change control policies.

Software & Data Management

The HNDK200-2 operates as a standalone benchtop instrument with no embedded software or network interface—prioritizing operational simplicity, electromagnetic interference resilience, and long-term serviceability. All parameters are configured locally via tactile keypad and LED display. Temperature profiles are stored in non-volatile memory and persist through power cycles. For laboratories requiring electronic recordkeeping, optional external data loggers (e.g., calibrated thermocouple arrays + USB dataloggers) may be deployed to capture time-stamped temperature and runtime data—supporting ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate) in GxP-regulated settings. No proprietary drivers or cloud dependencies are required; raw CSV export from third-party loggers ensures full data ownership and interoperability with validated ELN platforms.

Applications

• Routine concentration of extracts prior to GC-MS, LC-MS/MS, or HPLC analysis in environmental testing (e.g., pesticide residues in soil/water per EPA Method 525.3)
• High-volume steroid hormone quantification in clinical serum/plasma using immunoassay or mass spectrometry workflows
• Preparative cleanup of SPE-eluates in food safety labs (e.g., mycotoxin analysis per AOAC 2005.08)
• Parallel evaporation of derivatized amino acid standards in metabolomics pipelines
• Controlled drying of RNA/DNA eluates post-column purification to prevent nuclease activation or hydrolysis
• Stabilization of thermolabile compounds (e.g., prostaglandins, eicosanoids) where vacuum-induced degradation occurs in rotary evaporators

FAQ

What is the maximum recommended nitrogen pressure for safe operation?
The inlet pressure must not exceed 0.1 MPa (1 bar). Exceeding this limit may compromise gas channel integrity or cause uncontrolled flow surges affecting evaporation kinetics.

Can the instrument be used with solvents boiling below 40°C?
Yes—provided the system is operated inside a certified fume hood and gas flow is reduced to maintain gentle surface agitation without splashing. Low-boiling solvents require tighter temperature control (±0.5°C) and lower flow rates (≤3 L/min).

Is calibration certificate included with shipment?
No. A factory-issued temperature calibration report (traceable to NIST standards) is available upon request at time of order. On-site verification using a calibrated PT100 probe is recommended prior to first use and annually thereafter.

Are replacement modules available for non-standard tube formats?
Yes. Custom-machined blocks—including tapered, conical, or deep-well configurations—can be ordered directly from Hanuo’s OEM division with lead times of 4–6 weeks. Design specifications must conform to the base footprint (95.5 × 76.5 mm) and thermal mass constraints.