Hebei Jihepu ZLGJ-10 Benchtop Freeze Dryer

Overview

The Hebei Jihepu ZLGJ-10 Benchtop Freeze Dryer is a compact, integrated primary drying system engineered for routine lyophilization of biological, pharmaceutical, and analytical samples in academic, quality control, and R&D laboratories. It operates on the fundamental principle of sublimation—removing water from frozen samples under deep vacuum while maintaining product integrity through precise thermal management. Unlike cascade or condenser-integrated systems requiring external cold traps, the ZLGJ-10 features an all-in-one architecture with a dedicated air-cooled condenser (-55 °C standard, optionally -80 °C), eliminating dependency on ultra-low temperature freezers for pre-freezing. Its 0.1 m² shelf area supports scalable batch processing of bulk powders, gels, or vial-based formulations, with validated performance across the full lyophilization cycle: freezing, primary drying (sublimation), and secondary drying (desorption).

Key Features

• Monolithic stainless steel construction: Condenser chamber and drying chamber fabricated from electropolished 304 stainless steel—chemically inert, corrosion-resistant, and compliant with GLP surface requirements for traceability and cleaning validation.
• Patented gas flow path design: Optimized vapor trajectory ensures uniform ice deposition across the entire condenser surface, maximizing capture efficiency and minimizing re-deposition risk during extended runs.
• Intelligent vacuum sequencing: Vacuum pump activation is thermally gated—delayed until condenser reaches operational temperature—to prevent oil backstreaming and extend pump service life; includes automatic pump protection logic and pressure ramping profiles.
• Industrial 7-inch color touchscreen interface powered by SH-HPSC-II modular controller: Offers real-time PID-regulated control of shelf temperature (via optional shelf heating), condenser temperature, and chamber pressure; supports multi-step program storage (up to 32 user-defined cycles).
• Comprehensive sensor suite with NIST-traceable calibration support: Integrated Pt100 probes monitor condenser surface temperature, chamber pressure (capacitance manometer), and optional sample thermocouples; built-in calibration offset adjustment maintains long-term measurement fidelity.
• User-accessible security hierarchy: Three-tier permission levels (Operator, Technician, Administrator) enforced via password authentication; all parameter changes and cycle initiations logged with timestamp and user ID.

Sample Compatibility & Compliance

The ZLGJ-10 accommodates diverse sample formats—including bulk solutions in stainless steel trays (Ø180 mm × 4 units), standard pharmaceutical vials (Ø12/16/22 mm), and custom containers up to 70 mm height between shelves. All wetted surfaces contact only 304 stainless steel or food-grade silicone gaskets—no aluminum, brass, or polymer components exposed to process vapors. The system meets core laboratory infrastructure requirements per ISO 14644-1 Class 8 cleanroom compatibility (when operated in controlled environments), supports 21 CFR Part 11-compliant electronic record generation when paired with validated data export workflows, and aligns with ASTM F2476-20 (Standard Guide for Lyophilization Process Development) for method transfer readiness. Environmental operation limits (10–30 °C ambient, ≤70% RH) ensure stable condensation kinetics without refrigerant overloading.

Software & Data Management

Data acquisition occurs at 1-second intervals across all critical parameters: condenser temperature, chamber pressure, and optional probe inputs. Time-stamped curves are rendered live on-screen and stored internally (≥30 days of continuous logging). Export is supported via USB 2.0 to CSV format—compatible with Excel, MATLAB, and LIMS platforms. No proprietary software installation is required; raw files contain column headers, UTC timestamps, and engineering units (°C, Pa, %RH). Audit trails include operator login/logout events, cycle start/stop commands, setpoint modifications, and alarm acknowledgments—all non-erasable and time-locked. Optional firmware updates are delivered as signed binary packages with SHA-256 checksum verification.

Applications

• Stabilization of heat-labile biologics: Monoclonal antibodies, enzymes, vaccines, and viral vectors processed under low-temperature vacuum to preserve conformational integrity.
• Preparation of reference standards for HPLC, GC-MS, and ICP-MS analysis—eliminating solvent residues and ensuring mass stability during long-term storage.
• Routine dehydration of microbial cultures, plant extracts, and forensic tissue specimens where morphological preservation is essential.
• Method development for pharmaceutical lyophilization: Screening formulation excipients, optimizing primary drying endpoints via pressure rise test (PRT) integration, and validating shelf heat transfer coefficients (Kv).
• Academic research in cryobiology, nanomaterial synthesis (e.g., aerogel precursors), and food science (e.g., probiotic encapsulation).

FAQ

Does the ZLGJ-10 support shelf heating for controlled secondary drying?
Yes—optional electrically heated shelves (±0.5 °C accuracy) are available as a factory-installed upgrade; standard configuration includes passive shelves only.
Is the vacuum pump included with the base unit?
No—the system is supplied without a vacuum pump; a 2 L/s two-stage rotary vane pump meeting ISO 8573-1 Class 2 purity standards is recommended and sold separately.
Can the data logger meet FDA 21 CFR Part 11 requirements?
The embedded system provides electronic signatures, audit trails, and data immutability—but formal Part 11 compliance requires site-specific validation documentation, which Jihepu supplies upon request as part of IQ/OQ protocol packages.
What maintenance intervals are specified for the compressor and vacuum pump?
Compressor oil change every 24 months or 4,000 operating hours; vacuum pump oil replacement every 500 hours or quarterly—whichever occurs first; both schedules are tracked automatically in the controller’s service log.
Is remote monitoring supported via Ethernet or Wi-Fi?
Not natively—the current SH-HPSC-II controller supports USB export only; RS485 Modbus RTU output is available as an optional communication module for SCADA integration.