HengAo HDS-06A Fully Automated Sample Dilutor
| Brand | HengAo |
|---|---|
| Origin | Tianjin, China |
| Manufacturer Type | Original Equipment Manufacturer (OEM) |
| Country of Origin | China |
| Model | HDS-06A |
| Price Range | USD 14,000 – 28,000 |
Overview
The HengAo HDS-06A Fully Automated Sample Dilutor is an integrated liquid handling platform engineered for precision serial dilution, standard curve preparation, and matrix-matched calibration in analytical laboratories. It operates on a positive-displacement pipetting principle with gravimetric and volumetric verification capabilities, ensuring traceable dilution accuracy across dynamic concentration ranges. Designed for compatibility with routine QC workflows in environmental testing, clinical chemistry, food safety, and pharmaceutical quality control labs, the system eliminates manual pipetting variability while maintaining full auditability under GLP and ISO/IEC 17025-compliant environments.
Key Features
- Automated multi-step dilution protocols: supports up to 6 sequential dilution steps per run with programmable dilution factors (1:2 to 1:10,000)
- Integrated dual-channel precision syringe pumps: 100 µL–5 mL dispensing range per channel, calibrated to ±0.5% volumetric accuracy at mid-range volumes
- Onboard gravimetric validation module: real-time mass measurement via high-resolution analytical balance (0.1 mg readability) for post-dilution verification and uncertainty calculation
- Modular reagent rack system: accommodates standard 15 mL and 50 mL conical tubes, 96-well microplates, and custom vial formats
- Touchscreen HMI with embedded method editor: intuitive drag-and-drop protocol builder supporting conditional logic, pause points, and error recovery routines
- RS-232, USB, and Ethernet connectivity: enables direct integration with LIMS, ELN, and laboratory information systems via ASTM E1384 or HL7-compliant data export
Sample Compatibility & Compliance
The HDS-06A handles aqueous buffers, organic solvents (up to 100% acetonitrile or methanol), viscous samples (up to 50 mPa·s), and particulate-containing matrices (e.g., filtered wastewater, centrifuged serum). All wetted components—including syringe barrels, PTFE-coated plungers, and fluidic manifolds—are chemically resistant and autoclavable. The instrument meets CE marking requirements for electromagnetic compatibility (EN 61326-1) and electrical safety (EN 61010-1). Its operational documentation supports 21 CFR Part 11 compliance when deployed with optional electronic signature and audit trail modules, including time-stamped event logs, user access controls, and immutable method versioning.
Software & Data Management
The embedded HengAo DiluSoft™ v3.2 software provides full lifecycle method management—from protocol creation and validation to execution reporting. Each dilution run generates a structured PDF report containing sample IDs, target concentrations, actual measured masses/volumes, deviation metrics, operator ID, timestamp, and instrument calibration status. Raw data exports are available in CSV and XML formats compliant with ASTM E2500-07 (Standard Guide for Specification, Design, and Verification of Pharmaceutical and Biopharmaceutical Manufacturing Systems). Optional cloud synchronization enables remote monitoring and centralized archive management across multi-site laboratories.
Applications
- Preparation of certified reference material (CRM) dilutions for ICP-MS, AAS, and IC quantification
- Generation of linearity and recovery standards in bioanalytical method validation (per FDA Bioanalytical Method Validation Guidance)
- Automated dilution of high-concentration stock solutions prior to GC-FID or HPLC-UV analysis
- Matrix-matched calibration in environmental labs processing soil extracts or drinking water concentrates
- High-throughput dilution of ELISA and lateral flow assay reagents in diagnostic development workflows
- Supporting ISO 17025 clause 7.7 (Sampling) and clause 7.8 (Ensuring validity of results) through documented traceability and uncertainty estimation
FAQ
What volume ranges can the HDS-06A accurately dispense?
The system delivers precise liquid handling from 100 µL to 5 mL per aspiration/dispense cycle, with optimal reproducibility (CV < 0.8%) between 500 µL and 3 mL.
Does the instrument support unattended overnight operation?
Yes—equipped with thermal-stable syringe drive mechanics and automated tip ejection/waste management, it supports continuous batch runs of up to 96 samples without intervention.
Can dilution methods be validated per regulatory guidelines?
Absolutely. Built-in gravimetric verification, calibration certificate traceability to NIST SRMs, and configurable IQ/OQ documentation templates align with USP , ISO/IEC 17025, and GAMP 5 Category 3 software classification requirements.
Is third-party software integration supported?
Yes—via open API (RESTful JSON endpoints) and native drivers for Thermo Fisher SampleManager, LabVantage, and Waters Empower, enabling bidirectional method and result exchange.
What maintenance intervals are recommended?
Syringe pump calibration and seal inspection every 6 months; full fluidic path cleaning after 200 runs or when switching solvent families; annual performance qualification using certified volumetric standards.
