HengaoDe HA-WRS-2A Digital Micro Melting Point Apparatus for Pharmaceutical Crystalline Compounds
| Brand | HengaoDe |
|---|---|
| Origin | Beijing, China |
| Manufacturer Type | Authorized Distributor |
| Country of Origin | China |
| Model | HA-WRS-2A |
| Price | USD 42.50 (FOB) |
| Melting Range | Ambient to 300 °C |
| Temperature Resolution | 0.1 °C |
| Heating Rates | 0.2–5.0 °C/min (8 selectable steps) |
| Accuracy | ±0.5 °C (<200 °C), ±0.8 °C (≥200 °C) |
| Sample Capacity | 3 independent capillaries |
| Display | Backlit LCD with real-time melting curve |
| Interface | RS232 serial port |
| Dimensions | 398 × 280 × 170 mm |
| Weight | 11 kg |
Overview
The HengaoDe HA-WRS-2A Digital Micro Melting Point Apparatus is a precision laboratory instrument engineered for the quantitative determination of melting point ranges in crystalline organic compounds—primarily pharmaceuticals, dyes, fragrances, and fine chemical intermediates. It operates on the principle of controlled linear heating coupled with photometric detection of sample opacity transitions during solid-to-liquid phase change. Unlike traditional capillary tube methods relying on visual observation, the HA-WRS-2A employs an integrated optical sensor array to detect the onset and completion of melting with high reproducibility. The system automatically identifies initial melt (onset), clear point (end), and calculates their arithmetic mean—reducing operator-dependent variability. Its temperature-controlled metal block ensures uniform thermal distribution across all three sample positions, supporting comparative analysis under identical thermal profiles per ASTM E324 and ISO 6321 standards.
Key Features
- Triple-capillary simultaneous measurement capability for enhanced throughput and inter-sample consistency
- Eight programmable linear heating rates (0.2–5.0 °C/min), enabling method optimization for thermally sensitive or high-melting-point compounds
- Real-time backlit LCD display showing dynamic melting curves, current temperature, and stage-specific status indicators
- Photodiode-based optical detection system with automatic threshold calibration, eliminating subjective endpoint judgment
- RS232 serial interface compliant with LabVIEW and third-party LIMS integration for audit-ready data export
- Robust aluminum alloy housing with passive heat dissipation design, ensuring stable operation over extended assay cycles
- Compliance-ready firmware architecture supporting GLP documentation requirements, including user-defined ID tagging and timestamped result logs
Sample Compatibility & Compliance
The HA-WRS-2A accommodates standard 1.0–1.2 mm OD glass capillaries filled to 3–5 mm height—compatible with USP , EP 2.2.17, and JP 17 methodologies. It supports both pure reference standards and crude reaction mixtures, provided samples are dry and free of volatile solvents. The instrument meets essential safety and electromagnetic compatibility criteria per IEC 61010-1:2010 (Laboratory Equipment Safety) and EN 61326-1:2013 (EMC for Measurement Instruments). While not FDA 21 CFR Part 11 certified out-of-the-box, its RS232 output enables traceable data capture within validated enterprise systems meeting Part 11 and Annex 11 requirements.
Software & Data Management
Data acquisition is performed via direct serial communication using ASCII protocol. Each measurement record includes: sample ID, operator code, date/time stamp, heating rate, observed onset/clear temperatures, calculated mean, and raw photometric signal intensity vs. time. Optional PC software (supplied on USB drive) provides graphing, statistical summary (n=3 mean ± SD), CSV export, and PDF report generation with embedded instrument metadata. All stored results retain full traceability—including parameter settings at time of run—to satisfy internal QA review and external regulatory inspection protocols.
Applications
- Pharmaceutical QC release testing per monograph specifications (e.g., paracetamol, ibuprofen, caffeine)
- Purity assessment of synthetic intermediates during route scouting and process development
- Stability-indicating method development for accelerated degradation studies
- Educational use in undergraduate organic chemistry laboratories for compound identification and characterization
- Raw material verification in contract manufacturing organizations (CMOs) adhering to ICH Q5 and Q7 guidelines
FAQ
Does the HA-WRS-2A comply with pharmacopoeial melting point test requirements?
Yes—it fulfills the procedural and performance criteria outlined in USP , EP 2.2.17, and JP 17 for manual and semi-automated melting point determination.
Can the instrument be calibrated using NIST-traceable standards?
Absolutely. Certified reference materials (e.g., indium, caffeine, phenacetin) with documented uncertainty budgets may be used for periodic verification of temperature accuracy and heating rate fidelity.
Is remote monitoring or network connectivity supported?
The built-in RS232 port allows connection to local PCs or industrial PLCs; Ethernet or Wi-Fi modules are not included but can be added via third-party serial-to-Ethernet converters compatible with Modbus RTU protocol.
What maintenance is required to ensure long-term accuracy?
Annual verification of thermal block uniformity and optical sensor response is recommended. No consumables other than standard capillaries are required; cleaning involves only lint-free isopropyl alcohol wipes on the optical window.
How does the HA-WRS-2A handle samples with broad or ambiguous melting ranges?
The photometric algorithm detects inflection points in transmittance decay; users may manually adjust detection thresholds via service menu to accommodate polymorphic or decomposing substances—documented in the instrument’s electronic logbook.
