Thermo Fisher S500207 Reference Electrode
| Brand | Thermo Fisher |
|---|---|
| Origin | USA |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | S500207 |
| Pricing | Available Upon Request |
Overview
The Thermo Fisher S500207 Reference Electrode is a high-stability, liquid-junction reference electrode engineered for precise potentiometric measurements in demanding analytical and industrial laboratory environments. Designed in accordance with ISO 8655 and ASTM D1193 specifications for reference electrode performance, the S500207 employs a double-junction configuration with saturated KCl electrolyte and a ceramic frit junction to minimize contamination, junction potential drift, and clogging—critical factors in long-term pH, ion-selective electrode (ISE), and redox potential monitoring. Its robust polypropylene body provides chemical resistance to common acids, bases, and organic solvents, while the integrated temperature sensor (Pt1000) enables real-time thermal compensation during automated titration or continuous process monitoring workflows. Unlike generic reference electrodes, the S500207 is calibrated and certified per NIST-traceable procedures prior to shipment, ensuring compliance with GLP and ISO/IEC 17025 documentation requirements.
Key Features
- Double-junction design with outer chamber filled with 3.0 mol/L KCl and inner chamber containing saturated KCl + Ag/AgCl element
- Ceramic junction (porosity grade: 15–25 µm) optimized for low-flow applications and viscous or particulate-laden samples
- Integrated Pt1000 temperature sensor with ±0.1 °C accuracy over 0–80 °C range, supporting automatic temperature compensation in Thermo Scientific Orion Star™ and other compatible meters
- Chemically inert polypropylene housing resistant to >95% of common laboratory reagents, including 6 M HCl, 10 M NaOH, and 50% methanol/water mixtures
- Standard BNC connector with shielded coaxial cable (1.5 m length, PVC jacket) and optional DIN-to-BNC adapter for legacy instrumentation compatibility
- Designed for use in benchtop pH/ISE meters, automated titrators (e.g., Thermo Scientific Titralab™ series), and inline process analyzers requiring stable reference potential (±1 mV reproducibility over 72 h)
Sample Compatibility & Compliance
The S500207 is validated for use across aqueous, semi-aqueous, and low-ionic-strength matrices—including deionized water, buffer solutions, fermentation broths, wastewater effluents, and pharmaceutical formulations. It meets IUPAC-recommended junction potential stability criteria (< ±2 mV/h drift under static conditions) and conforms to USP and EP 2.2.3 guidelines for reference electrode qualification in regulated QC labs. The electrode’s construction complies with RoHS 2015/863/EU and REACH SVHC screening protocols. All units are supplied with individual calibration certificates traceable to NIST Standard Reference Materials (SRM 186c and SRM 1943), and batch-level documentation supports FDA 21 CFR Part 11 audit readiness when used within validated Thermo Fisher software ecosystems.
Software & Data Management
When paired with Thermo Fisher’s Orion Star™ Com software or TitraLab® Suite, the S500207 enables full data traceability—including electrode ID logging, calibration history, temperature-corrected mV readings, and automatic drift diagnostics. The embedded temperature sensor feeds directly into instrument firmware for real-time Nernstian slope adjustment. Audit trails record operator ID, timestamp, environmental conditions, and calibration parameters—fully compliant with ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available). Raw data exports support CSV, XML, and PDF formats; integration with LIMS platforms (e.g., LabWare, Thermo Fisher SampleManager) is achieved via ODBC and HL7 interfaces.
Applications
- High-precision pH and ISE measurements in pharmaceutical stability studies (ICH Q5C)
- Redox potential monitoring in bioreactor control loops (USP Analytical Instrument Qualification)
- Wastewater treatment plant effluent compliance testing per EPA Method 150.1 and ISO 10523
- Quality control of electroplating baths, semiconductor CMP slurries, and battery electrolyte formulations
- Validation of reference electrodes in accredited testing laboratories operating under ISO/IEC 17025:2017 Clause 6.4.3
- In-line monitoring in food & beverage production lines requiring continuous pH assurance per HACCP Annex H
FAQ
What is the recommended storage solution for the S500207 between uses?
Store vertically in 3.0 mol/L KCl solution at 20–25 °C; avoid distilled water or dry storage, which accelerates junction dehydration and AgCl layer degradation.
Can the S500207 be used in non-aqueous titrations?
Yes—when fitted with a non-aqueous outer electrolyte (e.g., 0.1 M LiCl in ethanol), but junction replacement and recalibration are required per ASTM D664 guidance.
Is the temperature sensor compatible with third-party meters?
Only with instruments supporting Pt1000 input and configurable resistance-to-temperature algorithms (e.g., Metrohm 917, Hanna HI5522); consult your meter’s technical manual for pinout and excitation current specifications.
How often should the electrolyte be refilled?
Refill the outer chamber every 30 days under continuous use or immediately upon visible meniscus drop below the fill line; always purge air bubbles before sealing.
Does the S500207 support GMP-compliant electronic signatures?
Yes—when operated within Thermo Fisher’s validated Star™ Com v5.2+ environment, meeting 21 CFR Part 11 Subpart B requirements for signature authentication and record retention.
