HOGON AKF-3N Coulometric Karl Fischer Moisture Titrator
| Brand | HOGON |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Direct Manufacturer |
| Product Category | Domestic (China-Made) |
| Model | AKF-3N Coulometric Karl Fischer Moisture Titrator |
| Pricing | Available Upon Request |
Overview
The HOGON AKF-3N Coulometric Karl Fischer Moisture Titrator is a precision electrochemical analyzer engineered for trace-level water quantification in diverse chemical matrices using the coulometric Karl Fischer titration principle. Unlike volumetric methods, coulometric titration generates iodine electrochemically at the anode via controlled current, enabling ultra-sensitive detection down to 0.01 µg of water—ideal for low-moisture samples such as solvents, pharmaceutical excipients, lithium battery electrolytes, and high-purity polymers. The instrument operates on the stoichiometric reaction between iodine and water in a sealed anhydrous environment, ensuring high reproducibility and compliance with internationally recognized analytical standards including ASTM D6304, ISO 15512, USP , and EP 2.5.11. Its dual-electrode coulometric cell design minimizes drift and enhances long-term stability, making it suitable for regulated laboratory environments requiring audit-ready performance.
Key Features
- Ultra-trace sensitivity: Detection limit of 0.01 µg H₂O with automatic current regulation from 1 mA to 400 mA (resolution: 0.1 mA)
- Intelligent endpoint detection: Adaptive algorithm adjusts titration parameters in real time based on ambient humidity, sample reactivity, and electrolyte conductivity
- Integrated bromine index analysis capability: No hardware modification required—supports SH/T 1551–1993-compliant电量滴定 (coulometric bromine index determination) without accessory swaps
- Full-color capacitive touchscreen interface with numeric keypad and one-touch start; intuitive workflow navigation designed for non-specialist operators
- Onboard titration curve visualization: Real-time graphical display of potential vs. time during titration, enabling process diagnostics and method optimization
- Multi-method library: Preconfigured and user-editable methods for solids, liquids, gases, and bromine index—each with customizable drift correction, blank subtraction, and endpoint criteria
- Expandable platform: Optional accessories include heated titration stands, Karl Fischer ovens (up to 300 °C), and automated headspace samplers for thermally labile or insoluble samples (e.g., resins, graphite, lubricating oils)
- Self-diagnostic architecture: Continuous hardware status monitoring, automatic fault logging, programmable run termination, and scheduled shutdown functionality
Sample Compatibility & Compliance
The AKF-3N accommodates a broad range of sample types—including volatile organic solvents, viscous petrochemicals, hygroscopic powders, and reactive organometallic compounds—through configurable sample introduction protocols and adaptive drift compensation algorithms. It meets critical regulatory requirements for quality control laboratories operating under GLP, GMP, and ISO/IEC 17025 frameworks. Built-in audit trail functionality supports 21 CFR Part 11 compliance when paired with validated software configurations. Method validation documentation aligns with SH/T 0246 (light distillates), GB/T 6283–2008 (general chemical products), GB/T 11133–1989 (liquid petroleum), and GB/T 11146–1999 (crude oil), ensuring seamless integration into refinery QC, pharmaceutical stability testing, and advanced materials R&D workflows.
Software & Data Management
The embedded firmware enables secure storage of ≥1,000 test records with timestamped metadata, operator ID, method version, and raw titration curves. Data export is supported via USB and RS-232 interfaces in CSV and PDF formats. Optional PC-based software provides enhanced reporting, statistical trend analysis (e.g., control charts per ASTM E2587), electronic signature support, and multi-user permission management. All data handling adheres to ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available), facilitating inspection readiness for FDA, NMPA, and EU MHRA audits.
Applications
- Pharmaceutical: Residual moisture in lyophilized APIs, excipients, and packaging materials per USP
- Petrochemical: Water content in jet fuels (ASTM D6304), transformer oils, and synthetic lubricants
- Electronics: Moisture quantification in Li-ion battery electrolytes and cathode precursors
- Polymers & Composites: Trace water in polyamide, polycarbonate, and epoxy resin preforms prior to processing
- Agrochemicals: Water determination in pesticide formulations and technical-grade active ingredients
- Academic Research: Kinetic studies of hydrolysis reactions, catalyst hydration state analysis, and solvent purity verification
FAQ
What is the minimum detectable water mass using the AKF-3N?
The instrument achieves a detection limit of 0.01 µg H₂O under optimized coulometric conditions.
Does the AKF-3N support bromine index analysis per SH/T 1551–1993?
Yes—bromine index measurement is implemented natively via the same coulometric cell without hardware modification.
Can the system be integrated into a LIMS environment?
Yes, via ASCII-based serial output or optional software with ODBC connectivity for direct LIMS ingestion.
Is the instrument compliant with 21 CFR Part 11 for electronic records?
When deployed with validated software and appropriate access controls, the system supports Part 11 requirements for audit trails and electronic signatures.
What maintenance intervals are recommended for routine operation?
Daily electrode cleaning, weekly cell rinsing with dry methanol, and quarterly calibration verification using certified water standards (e.g., 1.00 mg/g Hydranal®).
