HsiangTai CN-350 Benchtop Low-Speed Centrifuge

Overview

The HsiangTai CN-350 is a precision-engineered benchtop low-speed centrifuge designed for routine separation tasks in clinical, pharmaceutical, and academic laboratories. Operating on the principle of sedimentation under controlled centrifugal force, it enables reliable phase separation of heterogeneous mixtures—including whole blood, cell suspensions, precipitated proteins, and particulate-laden solutions—without inducing thermal or mechanical stress associated with high-speed operation. Its brushless DC motor delivers consistent torque across the full speed range (500–6,000 rpm), ensuring high reproducibility and extended service life. Unlike ultra-centrifuges requiring vacuum chambers or cryogenic cooling, the CN-350 series is optimized for ambient-temperature applications (CN-350) or refrigerated operation (CN-350R, CN-350RD, CN-350RDS), making it suitable for protocols where sample integrity at moderate g-forces is critical—such as plasma isolation, yeast pellet recovery, or polymer precipitation.

Key Features

• Brushless DC motor with electronic speed control and real-time feedback for stable rotational performance and minimal vibration
• Digital LED interface displaying simultaneous readouts of rotational speed (rpm), relative centrifugal force (RCF), elapsed time, and temperature (refrigerated models)
• 10 programmable protocols with independent storage of speed, time, temperature (where applicable), and acceleration/deceleration profiles
• Intelligent auto-balancing algorithm that detects and compensates for minor load imbalances up to ±5% mass difference between opposing tubes
• Fail-safe mechanical and electronic safety systems: automatic lid interlock, rotor identification verification (via physical keying on compatible rotors), instantaneous brake activation upon lid opening or power interruption
• Three-stage deceleration profile (fast/standard/soft) to minimize resuspension of delicate pellets during stop cycles

Sample Compatibility & Compliance

The CN-350 accommodates a broad spectrum of standard laboratory vessels—including conical-bottom polypropylene tubes (1.5–100 mL), glass centrifuge bottles (up to 100 mL), and sealed microcentrifuge tubes—across multiple rotor configurations. Horizontal rotors (RS-50, RS-55) support high-capacity runs (e.g., 100 mL × 4 at 3,500 rpm / 1,980 × g), while angular rotors (RA-1512H, RA-5008) enable higher RCF generation (up to 4,270 × g) for denser particle recovery. All rotors are manufactured from anodized aluminum alloy and certified for autoclaving (121 °C, 20 min). The system complies with IEC 61010-1:2010 for electrical safety and meets ISO 13485 requirements for medical device manufacturing environments. Refrigerated variants (CN-350R/RD/RDS) adhere to ISO 15197:2013 thermal stability specifications for clinical analyte preservation.

Software & Data Management

While the CN-350 operates via embedded firmware without external PC connectivity, its internal memory logs operational metadata—including date/time stamp, protocol ID, final speed, actual RCF achieved, and error codes—for GLP-compliant recordkeeping. All displayed parameters conform to ISO 21501-4 traceable calibration standards. The timer function supports both countdown and hold-at-end modes, enabling unattended processing aligned with SOP-driven workflows. For facilities requiring audit trails, optional USB data export modules (sold separately) allow retrieval of run history files in CSV format, supporting FDA 21 CFR Part 11–compliant electronic records when paired with validated LIMS integration.

Applications

• Clinical diagnostics: Separation of serum/plasma from whole blood (EDTA, heparin, citrate tubes), urine sediment concentration, CSF analysis prep
• Cell biology: Harvesting adherent and suspension mammalian cells (HEK293, CHO, Jurkat), bacterial pellet collection (E. coli, Bacillus spp.), yeast centrifugation prior to lysis
• Pharmaceutical QC: Clarification of filtration eluates, excipient suspension homogenization checks, residual solvent removal from API intermediates
• Food & beverage testing: Fat extraction from milk homogenates, starch granule isolation, microbial load assessment in liquid samples
• Environmental labs: Sedimentation of suspended solids in wastewater effluents, microplastic concentration from aqueous matrices

FAQ

What is the maximum RCF achievable with the CN-350 using the RA-1512H rotor?
The RA-1512H angular rotor achieves a maximum RCF of 4,270 × g at 6,000 rpm with 15 mL tubes.
Is rotor compatibility interchangeable between CN-350 and CN-350R models?
Yes—all CN-350 series variants share identical rotor mounting interfaces and mechanical locking mechanisms; no recalibration is required when transferring rotors between units.
Does the CN-350 meet ISO 13485 requirements for use in medical device manufacturing?
Yes—the base unit and all factory-supplied rotors carry CE marking under Annex II of the IVDR and are documented in HsiangTai’s ISO 13485:2016 quality management system.
Can the timer be set beyond 99 minutes?
No—the built-in timer has a maximum setting of 99 minutes; for longer runs, users must configure sequential protocols or employ external timing controls.
What maintenance intervals are recommended for the brushless motor?
The brushless DC motor requires no scheduled lubrication or brush replacement; annual verification of vibration amplitude (<0.5 mm/s RMS) and thermal cut-off response is advised per ISO 17025 accreditation guidelines.