HUXI MS-CZ200 Heavy-Duty Magnetic Stirrer with Integrated Precision Weighing System

Overview

The HUXI MS-CZ200 is an industrial-grade magnetic stirrer engineered for large-scale liquid homogenization in regulated laboratory and pilot-scale biopharmaceutical environments. It operates on the principle of contactless torque transmission via rotating magnetic fields—eliminating mechanical shafts, seals, or drive penetrations that compromise sterility or introduce contamination pathways. Unlike conventional overhead stirrers, this system couples a high-torque brushless DC motor with a precision electromagnetic drive unit mounted beneath a seamless 304 stainless steel platform. The rotating magnetic field actuates standard PTFE- or glass-coated stir bars placed inside vessels—enabling consistent, laminar mixing of low-to-medium viscosity liquids up to 200 L. Critically, the integrated high-stability load cell system (500 kg capacity, 0.01 kg resolution, ±0.02 kg accuracy) transforms the device into a gravimetric dosing and blending platform. This dual-function architecture supports weight-based recipe execution—essential for GMP-compliant buffer preparation, media formulation, and dosage-controlled additive integration in cell culture, vaccine manufacturing, and oral liquid pharmaceutical production.

Key Features

• Integrated weighing and magnetic stirring in a single, space-efficient platform—reducing footprint and cross-contamination risk between separate balance and stirrer units.
• 304 stainless steel work surface and fully welded enclosure—resistant to corrosion from cleaning agents (e.g., 70% ethanol, hydrogen peroxide vapor), compatible with ISO 14644 cleanroom maintenance protocols.
• Brushless DC motor with closed-loop digital speed control—ensures stable rotational output across the full 20–1000 rpm range, even under variable load conditions; no carbon brush wear or electromagnetic interference.
• High-linearity, temperature-compensated load cells calibrated to OIML R76 Class III specifications—supporting traceable mass measurements compliant with USP , EP 2.1.11, and internal GLP audit requirements.
• Programmable timer (1–9999 minutes) with auto-stop and audible alert—enabling unattended overnight mixing cycles without operator intervention.
• Modular vessel compatibility—accommodates standard stainless steel, glass, or single-use bioprocess containers (e.g., 50–200 L carboys, jacketed reactors, disposable bags) via adjustable centering guides and non-slip platform coating.

Sample Compatibility & Compliance

The MS-CZ200 is validated for use with aqueous solutions, saline buffers, cell culture media, syrup bases, and low-viscosity pharmaceutical liquids (dynamic viscosity ≤ 500 mPa·s at 25 °C). It is not recommended for highly viscous, particulate-laden, or shear-sensitive suspensions requiring impeller-based agitation. All wetted surfaces are electropolished 304 stainless steel or chemically inert PTFE—meeting FDA 21 CFR Part 117 (food contact) and ISO 10993-5 (cytotoxicity) biocompatibility criteria. The system’s design aligns with Annex 1 (EU GMP) requirements for aseptic processing equipment: no lubricants, zero dead-leg geometry, and full clean-in-place (CIP) accessibility. Optional IQ/OQ documentation packages support qualification per ASTM E2500 and ISPE GAMP 5 guidelines.

Software & Data Management

While the base MS-CZ200 operates via intuitive front-panel controls (rotary encoder + LCD display), optional RS-485/Modbus RTU or USB-C interfaces enable integration with LabVantage, DeltaV, or custom SCADA systems. Logged data—including real-time weight, RPM, elapsed time, and event timestamps—is exportable as CSV for audit trail generation. When paired with compliant software, the system supports 21 CFR Part 11 electronic signatures, role-based access control, and immutable data archiving—fulfilling ALCOA+ (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available) data integrity principles.

Applications

• Buffer and media preparation in upstream bioprocessing (e.g., PBS, DMEM, fermentation feed stocks).
• Gravimetric blending of excipients and active pharmaceutical ingredients (APIs) in oral liquid dosage form development.
• Homogenization of vaccine adjuvant suspensions prior to sterile filtration.
• Cell culture expansion workflows requiring gentle, oxygen-preserving agitation of suspension-adapted CHO or HEK293 lines.
• Quality control labs performing dissolution medium conditioning per USP .
• R&D scale-up studies where mixing performance must correlate directly with production-scale magnetic drives.

FAQ

What is the maximum vessel height supported by the MS-CZ200 platform?
The platform accommodates vessels up to 650 mm in height when using the standard 16 × 100 mm stir bar; taller configurations require extended-length stir bars (e.g., 20 × 150 mm) and are subject to torque derating above 500 rpm.
Can the weighing function be calibrated in-house?
Yes—the system includes two-point calibration (zero and span) using certified test weights traceable to NIST or equivalent national metrology institutes; calibration logs are stored internally and exportable.
Is the MS-CZ200 suitable for use in ISO Class 5 environments?
When operated with appropriate gowning, sterilized stir bars, and validated cleaning procedures, the unit meets physical and material requirements for ISO Class 5; however, its electromagnetic emissions profile requires verification against IEC 61326-1 for specific cleanroom HVAC configurations.
Does the device support continuous weight monitoring during stirring?
Yes—weight updates at 10 Hz with full resolution; dynamic filtering algorithms suppress vibration-induced noise without compromising response time to actual mass changes.
What safety certifications does the MS-CZ200 hold?
It complies with IEC 61010-1 (Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use) and carries CE marking under the EU Low Voltage Directive and EMC Directive.