IKA LR-2.ST Modular Laboratory Reactor System with Jacketed Vessel

Overview

The IKA LR-2.ST is a modular, jacketed laboratory reactor system engineered for precise control and reproducible execution of synthetic, catalytic, polymerization, and process-optimization reactions under varied thermal, mechanical, and vacuum conditions. Based on Couette-type shear-driven mixing and jacketed heat transfer principles, the system integrates high-torque stirring, real-time torque monitoring, and temperature-regulated circulation through an external chiller or heating bath. Its core architecture supports scalable reaction development—from screening reaction kinetics at 500 mL to pilot-scale validation up to 2000 mL—while maintaining strict adherence to GLP-compliant documentation requirements via integrated digital interfaces.

Key Features

• Modular platform design enables seamless integration of ancillary modules: ULTRA-TURRAX® dispersers, PT100 temperature probes, reflux condensers, dosing units, and gas inlet/outlet manifolds—all mountable via standardized NS 29/32 and NS 14/23 ground-glass joints.
• EUROSTAR P7 high-torque drive unit delivers stable rotational control across the full speed range (8–290 rpm), with microprocessor-based closed-loop regulation ensuring ±1 rpm accuracy even under variable load conditions.
• Integrated relative torque measurement provides continuous, non-invasive viscosity trend analysis—critical for detecting gelation, precipitation, or phase inversion during exothermic or polymeric reactions.
• Jacketed borosilicate glass vessel (LR 2000.1) permits precise temperature control from ambient to +230 °C using circulating media; vacuum compatibility down to 25 mbar supports solvent removal, low-boiling-point reactions, and moisture-sensitive chemistry.
• All wetted components utilize chemically inert materials: DIN ISO 3585 borosilicate glass 3.3, perfluoroelastomer (FFPM) seals rated for aggressive solvents and thermal shock, PTFE-coated hardware, and corrosion-resistant 1.4571 (SS 316L equivalent) stainless steel structural elements.
• Digital connectivity includes RS232 serial interface for instrument control and data logging, plus analog 0–10 V output for torque or speed signal transmission to external SCADA or LIMS platforms—supporting 21 CFR Part 11–compliant audit trails when paired with validated software.

Sample Compatibility & Compliance

The LR-2.ST accommodates heterogeneous, viscous, and gas-evolving reaction mixtures—including slurries, organometallic catalysts, emulsions, and thermosetting resins—without compromising seal integrity or thermal uniformity. Its construction complies with DIN EN 60529 (IP42) for protection against solid ingress and water splashing, and meets CE marking requirements under the EU Machinery Directive 2006/42/EC and Low Voltage Directive 2014/35/EU. All electrical and mechanical safety protocols align with IEC 61010-1 for laboratory equipment. When operated with validated procedures and calibrated accessories, the system supports compliance with ASTM E2500, ISO 17025, and USP analytical instrument qualification frameworks.

Software & Data Management

While the LR-2.ST operates as a standalone system with front-panel controls, its RS232 port enables bidirectional communication with IKA’s labworldsoft® software (v4.0+), permitting remote parameter setting, real-time torque/speed/temperature trending, and automated protocol execution. Data export in CSV or XML formats facilitates traceability in regulated environments. The analog output channel allows connection to third-party PLCs or DCS systems for centralized process monitoring. All logged parameters—including timestamped speed setpoints, measured torque values, and external PT100 readings—are stored with metadata sufficient for GMP/GLP audit readiness.

Applications

• Kinetic profiling of catalytic hydrogenations, cross-coupling reactions, and enzymatic transformations under controlled temperature and agitation profiles.
• Development of pharmaceutical intermediates requiring strict thermal history control and solvent recovery under reduced pressure.
• Polymer synthesis (e.g., polycondensation, free-radical polymerization) where viscosity evolution must be tracked in situ to determine endpoint or avoid runaway gelation.
• Formulation studies involving nanoparticle dispersion, liposome hydration, or surfactant-mediated phase behavior under shear.
• Process intensification trials comparing batch vs. semi-batch operation, including controlled reagent addition and dynamic vacuum ramping.

FAQ

Can the LR-2.ST be used for reactions requiring inert atmosphere control?

Yes—the vessel head features multiple NS-ground-joint ports and optional gas-tight sealing kits compatible with nitrogen or argon purging; additional inert-gas sparging modules are available as accessories.
Is the torque measurement calibrated and traceable to national standards?

The relative torque signal is factory-calibrated and repeatable within ±3% FS; absolute viscosity calibration requires use of NIST-traceable standard fluids and separate rheometric validation.
What cooling/heating circulators are recommended for optimal jacket performance?

IKA recommends circulators with ≥1 kW heating/cooling capacity and ±0.1 °C stability (e.g., RC 20, RTC 110 series) to maintain thermal uniformity across the full 230 °C operating range.
Does the system support automated dosing integration?

Yes—via optional IKA Dosing Module DM 1000, which mounts directly to the support frame and synchronizes syringe pump actuation with stirrer speed and temperature ramps.
Are spare parts and seals available globally with documented shelf life?

All FFPM and PTFE seals carry manufacturer-certified shelf-life statements (≥5 years unopened); OEM spare parts are distributed through IKA’s authorized global service network with full lot traceability.