ISMATEC® REGLO Digital Piston Pump System with PH00 Plunger Pump Head

Overview

The ISMATEC® REGLO Digital Piston Pump System with PH00 plunger pump head is a precision-engineered positive-displacement fluid handling instrument designed for laboratories requiring high-pressure capability, volumetric accuracy, and long-term operational stability. Unlike peristaltic or diaphragm-based systems, this pump operates on a true reciprocating plunger principle—where a motor-driven piston displaces fluid within a sealed chamber to deliver consistent, pulse-free flow without reliance on compressible tubing or check valves. This architecture eliminates common sources of volumetric drift, such as tube fatigue, valve hysteresis, or backflow leakage, making it particularly suitable for applications demanding trace-level repeatability (e.g., calibration standard delivery, reagent dosing in automated analyzers, or solvent transfer in HPLC sample preparation). The system is engineered for integration into regulated environments where documentation integrity and operator accountability are essential.

Key Features

• 5-inch (12.7 cm) capacitive TFT/RGB touchscreen with wide viewing angle and responsive interface—enabling intuitive navigation through settings, real-time flow monitoring, and parameter adjustment without external peripherals.
• Three distinct operating modes: continuous flow (for steady-state infusion), volumetric dispensing (with programmable volume, speed, and drip-prevention logic), and timed dispensing (with start/stop triggers and interval sequencing).
• Valveless PH00 plunger pump head—featuring a single moving component (the piston) housed in chemically resistant PTFE and sapphire components—minimizing wear, reducing maintenance frequency, and eliminating valve-related failure modes.
• MasterflexLive® cloud connectivity—providing remote status monitoring, firmware update notifications, usage analytics, and secure access logs compliant with audit trail requirements under GLP and GMP frameworks.
• Three-tier user authentication system (Operator, Supervisor, Administrator) with role-specific permissions—ensuring controlled access to critical functions such as program editing, calibration reset, or system configuration changes.
• Front-panel and optional analog remote control compatibility—supporting both manual benchtop use and integration into larger automation platforms via 0–10 V or 4–20 mA analog I/O signals.

Sample Compatibility & Compliance

The PH00 pump head is compatible with a broad range of laboratory-grade liquids—including aqueous buffers, organic solvents (e.g., acetonitrile, methanol, THF), mild acids and bases, and viscous solutions up to 1,000 cP—provided chemical compatibility with PTFE, sapphire, and stainless steel wetted materials is verified. It is not intended for abrasive slurries, particulate-laden fluids, or gases. The system meets CE marking requirements and conforms to IEC 61000-6-2 (immunity) and IEC 61000-6-3 (emission) standards. While not inherently FDA 21 CFR Part 11 certified, MasterflexLive® supports Part 11 readiness through electronic signature-capable user authentication, immutable audit trails, and time-stamped event logging—facilitating validation in pharmaceutical QC labs operating under USP and Annex 11 guidelines.

Software & Data Management

MasterflexLive® serves as the centralized software layer for fleet management, performance diagnostics, and regulatory documentation. Each pump registers unique device identifiers, firmware versions, and operational history—including dispense cycles, error events, and user login sessions. Data export is supported in CSV format for integration with LIMS or ELN systems. All configuration changes and program modifications are timestamped and attributed to authenticated users, satisfying ALCOA+ data integrity principles. Local storage retains the last 1,000 operational events; cloud synchronization ensures redundancy and centralized oversight across multi-site installations.

Applications

• Automated sample dilution and standard preparation in environmental testing labs (e.g., EPA Method 200.8, ISO 17294-2).
• Precise reagent metering in clinical chemistry analyzers and immunoassay platforms.
• Controlled solvent delivery in preparative chromatography workflows where pulsation-free flow enhances column loading consistency.
• Calibration fluid dispensing in metrology labs performing gravimetric verification of pipettes and burettes (ISO 8655).
• Continuous infusion in bioreactor feed systems requiring stable, low-shear delivery of nutrient concentrates.

FAQ

Is the PH00 pump head compatible with aggressive solvents like chloroform or concentrated nitric acid?
Chemical compatibility must be validated case-by-case using Masterflex’s wetted materials guide. PH00 uses PTFE seals and sapphire components, which offer broad resistance—but strong oxidizers and halogenated solvents may require additional evaluation.
Can the pump be calibrated to NIST-traceable standards?
Yes—the system supports user-performed volumetric calibration using certified reference weights or flow meters. Calibration parameters are stored with date/time stamps and operator ID in MasterflexLive®.
Does the REGLO system support RS-232 or Ethernet communication protocols?
It features USB-C for local configuration and firmware updates, and relies on Wi-Fi or Ethernet-connected gateways for MasterflexLive® cloud integration. Native Modbus TCP or OPC UA is not supported out-of-the-box.
How often does the PH00 pump head require maintenance?
Under typical lab conditions with compatible fluids, the PH00 head requires inspection every 6–12 months. Seal replacement intervals exceed 10,000 cycles; no routine lubrication or valve servicing is needed.
Can multiple REGLO pumps be synchronized for coordinated dispensing?
While not natively synchronized via internal clocking, external PLC or PC-based control via analog I/O or MasterflexLive® API enables coordinated start/stop and volume-triggered sequencing across units.