ISMATEC® REGLO-IPC Digital 4-Channel Adjustable Tube Clamp for Peristaltic Pump Systems

Overview

The ISMATEC® REGLO-IPC Digital 4-Channel Adjustable Tube Clamp is a precision-engineered mechanical interface designed exclusively for use with the ISMATEC® REGLO-IPC and IPC-N series of multi-channel peristaltic pump drives. Unlike generic clamps, this component integrates seamlessly into the pump’s planetary gear-driven architecture—featuring eight stainless-steel rotors—to ensure uniform occlusion force distribution across all four pump heads. Its primary function is to secure silicone or thermoplastic elastomer tubing within the pump head housing while maintaining optimal compression geometry for consistent peristaltic action. This design minimizes pulsation amplitude (<±1.5% CV under steady-state flow), enhances volumetric reproducibility, and extends tubing service life by reducing localized fatigue at pinch points. The clamp is not a standalone pump but a critical subsystem component enabling traceable, GLP-compliant fluid handling in regulated environments such as pharmaceutical QC labs, bioprocess development suites, and analytical chemistry workflows.

Key Features

• Precision-machined, tool-free adjustable clamping mechanism with calibrated torque retention—ensures repeatable tubing seating depth across multiple installation cycles
• Four independent channel alignment guides compatible with Micropump A- and B-type pump heads (tubing ID range: 0.5–6.4 mm)
• Stainless-steel structural frame with chemical-resistant polymer contact surfaces—validated for compatibility with aqueous buffers, organic solvents (e.g., IPA, acetonitrile), and mild caustics (pH 2–12)
• Integrated mounting interface compliant with DIN 46277-1 standard rack dimensions—enables direct integration into automated liquid handling platforms
• Designed for thermal stability across ambient operating ranges (5–40 °C) without dimensional drift affecting occlusion consistency

Sample Compatibility & Compliance

The clamp itself does not contact samples directly; it secures tubing that serves as the sole fluid pathway. When used with USP Class VI-certified silicone tubing (e.g., Masterflex® PharMed® BPT) or FDA-compliant Santoprene®, the full fluid path meets ISO 10993-5 cytotoxicity requirements. The mechanical assembly complies with IEC 61000-6-2 (immunity) and IEC 61000-6-4 (emissions) standards when installed in accordance with Masterflex® system integration guidelines. It supports audit-ready operation under 21 CFR Part 11 when paired with REGLO-IPC firmware v3.2+ and MASTERFLEXLIVE® software configured for electronic signature and change control.

Software & Data Management

While the clamp is a passive mechanical component, its performance is intrinsically linked to the digital control ecosystem of the REGLO-IPC drive. Firmware-controlled occlusion calibration routines (accessible via the 5” capacitive TFT touchscreen) automatically compensate for tubing wear over time—reducing manual recalibration frequency by up to 70%. MASTERFLEXLIVE® software (v2.8+) logs clamp-related operational parameters—including total run hours per channel, cumulative tubing compression cycles, and deviation alerts during quantitative dispensing sequences—for inclusion in equipment maintenance records. Audit trails are timestamped, user-ID-tagged, and exportable in CSV or PDF formats compliant with ALCOA+ data integrity principles.

Applications

• Continuous perfusion in cell culture bioreactors requiring stable, low-shear media delivery across four parallel lines
• Automated reagent dispensing in clinical diagnostics analyzers—particularly where cross-contamination avoidance mandates dedicated tubing per assay channel
• Multi-stream solvent gradient generation in preparative HPLC systems using chemically resistant tubing
• Calibration fluid distribution in environmental monitoring stations with remote TTL-triggered start/stop capability
• GMP-compliant buffer preparation suites where tubing change logs must be electronically linked to batch records

FAQ

Is this clamp compatible with non-ISMATEC® pump drives?
No. Mechanical and electrical synchronization is only guaranteed with ISMATEC® REGLO-IPC and IPC-N series drives due to proprietary rotor pitch, cam profile, and encoder feedback integration.
Does the clamp include tubing?
No. Tubing must be selected separately based on chemical compatibility, pressure rating, and flow requirements—Masterflex® provides application-specific tubing selection matrices in Technical Bulletin TB-2023-04.
Can occlusion pressure be adjusted per channel?
No. Occlusion is factory-calibrated to meet ISO 8536-4 tolerances for peristaltic pump tubing compression; field adjustment voids calibration certification and is not supported.
What maintenance is required?
Visual inspection for polymer wear or metal deformation every 500 operational hours; cleaning with 70% ethanol followed by air drying—no lubrication required.
Is replacement documentation traceable to serial number?
Yes. Each clamp ships with a Certificate of Conformance (CoC) listing material lot numbers, dimensional verification reports, and ISO 17025-accredited test data from Masterflex® Quality Assurance Lab.