JY88-IIN Ultrasonic Cell Disruptor
| Origin | Zhejiang, China |
|---|---|
| Manufacturer Type | Distributor |
| Origin Category | Domestic (China) |
| Model | JY88-IIN |
| Price | ¥13,600 |
| Instrument Type | Ultrasonic Disruptor |
| Sample Compatibility | Soft biological samples |
| Output Particle Size | 0.01–0.5 mm |
| Maximum Feed Particle Size | <15 mm |
| Sieve Cut-Off | 40 mesh |
| Batch Processing Volume | 10–200 mL |
| Frequency Range | 20–25 kHz |
| Display | Backlit LCD |
| Power Output | 250 W (adjustable from 5% to 99%) |
| Standard Probe Diameter | 6 mm |
| Optional Probe Diameters | 3 mm |
| Duty Cycle | 1–99% |
| Timing Resolution | 0.1 s (ultrasonication time, interval time, total time) |
| Operating Voltage | 220 V / 110 V, 50 Hz / 60 Hz |
| Dimensions (Main Unit) | 40 × 28 × 22 cm |
| Net Weight (Main Unit + Transducer) | 9.8 kg |
| Packaging Dimensions | 534 × 295 × 435 mm |
Overview
The JY88-IIN Ultrasonic Cell Disruptor is a benchtop ultrasonic processor engineered for precise, reproducible cell lysis and sample homogenization in life science and pharmaceutical laboratories. It operates on the principle of high-intensity ultrasonic cavitation—where rapid pressure fluctuations in a liquid medium generate transient microbubbles that collapse violently, producing localized shear forces, microstreaming, and extreme temperature gradients. This physical mechanism enables efficient disruption of soft biological matrices—including mammalian cells, bacterial suspensions, yeast, plant tissues, viral particles, and subcellular organelles—without introducing chemical contaminants or thermal degradation when operated under controlled duty cycles and cooling conditions.
Key Features
- Microprocessor-controlled operation with centralized firmware management and real-time parameter feedback via backlit LCD display
- Continuous, stepless ultrasonic power adjustment from 5% to 99% (0.1% increments), enabling fine-tuned energy delivery for sensitive samples
- Pulse mode functionality with independently programmable sonication duration, pause interval, and total cycle count—each adjustable to ±0.1 second resolution
- Integrated self-diagnostic test mode for transducer impedance verification and system readiness confirmation prior to operation
- Standard 6 mm titanium alloy probe (horn) optimized for general-purpose lysis; optional 3 mm probe available for low-volume, high-shear applications (e.g., nanomaterial dispersion)
- Robust aluminum alloy chassis with vibration-damping base; compact footprint (40 × 28 × 22 cm) suitable for standard fume hoods and biosafety cabinets
- Dual-voltage compatibility (110 V / 220 V, 50 Hz / 60 Hz) for international deployment without external transformers
Sample Compatibility & Compliance
The JY88-IIN is validated for use with soft, aqueous-based biological samples including cultured cells (adherent and suspension), Gram-positive and Gram-negative bacteria, yeast, soft plant tissues (e.g., leaf mesophyll, root tips), and isolated organelles. It is not intended for hard, fibrous, or highly viscous samples requiring mechanical grinding or bead-beating. While the instrument itself does not carry CE, UL, or FDA 510(k) certification, its operational parameters align with common laboratory practice guidelines referenced in ISO 13408-1 (sterility assurance), ASTM E2874 (ultrasonic equipment validation), and USP <1043> (general chapter on ultrasonic cleaning and processing). Users are responsible for validating process parameters per GLP/GMP requirements where applicable.
Software & Data Management
The JY88-IIN features embedded firmware with non-volatile memory storage for up to 10 user-defined protocols. Each protocol retains settings for power level, pulse timing, total duration, and duty cycle. No external software or PC interface is provided; all configuration and execution occur locally via front-panel controls. For regulated environments requiring audit trails, users may integrate external logging systems (e.g., USB data loggers or LabVIEW-compatible DAQ modules) to record timestamped operational events. The device supports manual operation only and does not comply with FDA 21 CFR Part 11 electronic records/signatures requirements out-of-the-box.
Applications
- Cell lysis for protein extraction, nucleic acid isolation, and enzyme release
- Preparation of antigenic lysates for immunoassay development
- Nanoparticle dispersion and stabilization in aqueous colloidal suspensions
- Emulsification of oil-in-water formulations for drug delivery research
- Accelerated solvent extraction of phytochemicals from plant material
- Disruption of biofilms for antimicrobial susceptibility testing
- Homogenization of tissue samples prior to HPLC or LC-MS analysis
FAQ
What is the maximum recommended continuous operating time per cycle?
For thermal stability and transducer longevity, continuous operation should not exceed 5 minutes without a minimum 2-minute cooling interval. Pulse mode is strongly recommended for extended processing.
Can this unit be used in cold rooms or with ice baths?
Yes—operation at ambient temperatures between 4 °C and 35 °C is supported. Submersion of the probe tip in an ice-cooled water bath is standard practice to prevent sample overheating during lysis.
Is calibration traceable to national standards?
The JY88-IIN does not include factory-calibrated power output verification. Users should perform periodic acoustic power measurements using calorimetric methods (e.g., ASTM E2471) if quantitative energy delivery is critical to their SOPs.
Does the instrument support serial communication or remote triggering?
No—this model has no RS-232, USB, or Ethernet connectivity. All control is local and manual.
What safety precautions apply during operation?
Always wear ANSI-approved ultrasonic hearing protection when operating above 50% power in open lab environments. Never operate the probe outside a liquid medium—dry activation will irreversibly damage the transducer.
