KEZHE VNH-1200 Vacuum Parallel Concentrator

Overview

The KEZHE VNH-1200 Vacuum Parallel Concentrator is an engineered solution for high-throughput, solvent-efficient sample concentration in analytical and preparative laboratories. It operates on the principle of vacuum-assisted evaporation under controlled heating and agitation—eliminating reliance on inert gas purging (e.g., nitrogen) while maintaining thermal integrity of thermolabile analytes. Unlike single-vessel rotary evaporators or nitrogen blow-down systems, the VNH-1200 enables simultaneous, independent concentration of up to 12 samples in standardized tail-tube format, with precise vacuum regulation, programmable thermal gradients, and integrated condensate recovery. Its design prioritizes reproducibility, operator safety, and environmental compliance—particularly critical in regulated environments where solvent emissions, cross-contamination risk, and audit-ready process documentation are subject to scrutiny under GLP, ISO/IEC 17025, and EPA Method-compliant workflows.

Key Features

• 12-position parallel processing with individual vacuum-sealed lids—prevents cross-contamination and ensures consistent vapor-phase isolation per sample;
• Integrated vortex agitation (0–600 rpm) synchronized with vacuum and temperature control to enhance mass transfer and prevent bumping or foaming;
• Tail-tube geometry (0.3 mL / 1 mL / 3 mL options) maintains a cold zone at the base during operation, minimizing thermal degradation of sensitive compounds such as peptides, metabolites, or labile pharmaceuticals;
• Programmable 9-step temperature profile (0–10 hours per step), enabling method-specific ramp-and-hold protocols aligned with compound volatility and matrix complexity;
• Adjustable vacuum control via large LCD interface—supports fixed setpoints or dynamic vacuum gradients (1 mbar to atmospheric pressure);
• Self-contained condensation system with recirculating chiller (−10 °C to +25 °C) achieves >95% solvent recovery efficiency for common organic solvents (e.g., methanol, acetonitrile, ethyl acetate, dichloromethane);
• Maintenance-free, variable-speed diaphragm vacuum pump (1.8 m³/h, ultimate vacuum ≤8 mbar absolute) with pressure stabilization feedback;
• Touchscreen HMI with real-time display of vacuum level, bath temperature, agitation speed, elapsed time, and active program step;
• Modular architecture allows direct integration with ASE (Accelerated Solvent Extraction) and SPE (Solid-Phase Extraction) platforms—enabling seamless transfer-free workflow from extraction to quantitative concentration.

Sample Compatibility & Compliance

The VNH-1200 accommodates standard 12 × 75 mm or 12 × 100 mm test tubes equipped with tapered tail-tubes. Sample volume range (5–120 mL) supports diverse applications—from low-volume biofluid extracts to high-capacity environmental water concentrates. All wetted components are chemically resistant (borosilicate glass, PTFE, stainless steel 316), ensuring compatibility with acidic, basic, and halogenated solvents. The system meets CE marking requirements and conforms to IEC 61010-1 for laboratory electrical safety. Its closed-loop solvent recovery design aligns with OSHA PEL and EU REACH guidelines for volatile organic compound (VOC) exposure mitigation. For regulated QC/QA labs, optional audit-trail logging (via external USB or Ethernet module) supports adherence to FDA 21 CFR Part 11 data integrity principles when paired with validated software protocols.

Software & Data Management

While the VNH-1200 operates autonomously via its embedded touchscreen controller, it supports export of run logs (CSV format) containing timestamped vacuum, temperature, agitation, and program stage data. Optional firmware upgrade enables RS-232 or Ethernet connectivity for integration into LIMS or ELN ecosystems. All parameter settings—including vacuum setpoints, thermal profiles, and agitation sequences—are stored locally with non-volatile memory retention. No proprietary software installation is required; configuration remains accessible via intuitive icon-driven navigation. System diagnostics—including pump status, chiller temperature deviation, and lid seal verification—are continuously monitored and displayed with actionable alerts.

Applications

• Quantitative concentration of LC-MS/MS extracts prior to reconstitution and injection;
• High-throughput cleanup of pesticide residues in food matrices (AOAC 2007.01, EN 15662);
• Pre-concentration of trace metals and organic pollutants from aqueous environmental samples (EPA 525.3, ISO 17923);
• Stabilization of unstable APIs during formulation development;
• Parallel processing of clinical urine, plasma, or CSF samples in biomarker discovery pipelines;
• Integration with automated solid-phase extraction (SPE) manifolds for walk-away sample preparation in regulated bioanalytical labs.

FAQ

Does the VNH-1200 require nitrogen or other inert gas for operation?
No—it relies solely on vacuum-assisted evaporation and does not consume nitrogen or compressed air.
Can the system handle high-boiling-point solvents like DMSO or DMF?
Yes, when used with the 150 °C heating platform and optimized vacuum profile (e.g., staged pressure reduction), though extended dwell times may be required.
Is method validation support available for GxP environments?
KEZHE provides IQ/OQ documentation templates and can supply factory-verified calibration certificates for temperature, vacuum, and timing subsystems.
What maintenance is required for the diaphragm vacuum pump?
None—the pump is oil-free and sealed; only periodic inspection of inlet filters and condensate trap drainage is recommended.
Are custom tail-tube configurations supported?
Standard offerings include 0.3 mL, 1 mL, and 3 mL calibrated tail volumes; bespoke geometries can be quoted upon request with minimum order quantities.