LabTech PrepElite-SV Fully Automated Sample Preparation Platform
| Brand | LabTech |
|---|---|
| Origin | USA |
| Manufacturer Type | Manufacturer |
| Origin Category | Imported |
| Model | PrepElite-SV |
| Automation Level | Fully Automatic |
| Number of Channels | Multi-channel |
| Extraction Mode | Column-based SPE |
| Flow Rate Control | 0–120 mL/min |
| Solvent Types Supported | 8 distinct solvents |
| Sample Capacity | 124 positions |
| Sample Loading Volume | 1–6 mL |
| Wetted Materials | Borosilicate Glass |
Overview
The LabTech PrepElite-SV Fully Automated Sample Preparation Platform is an integrated, modular system engineered for high-throughput, reproducible sample cleanup and concentration prior to chromatographic analysis. It operates on the principle of solid-phase extraction (SPE) combined with programmable solvent evaporation under controlled nitrogen or inert gas flow—enabling sequential or parallel execution of conditioning, loading, washing, elution, and post-elution concentration steps. Designed specifically for complex matrices—including fatty tissues, edible oils, pesticide-spiked agricultural commodities, environmental sediments, and biological fluids—the PrepElite-SV delivers robust matrix removal while preserving analyte integrity and recovery. Its architecture supports both fully coupled SPE-to-concentration workflows and independent module operation, ensuring method flexibility without compromising analytical rigor. The platform meets core requirements for regulated laboratories performing residue analysis in accordance with AOAC Official Methods, EPA Method 500/600 series, ISO 17025-compliant validation protocols, and EU SANTE/11312/2021 guidelines.
Key Features
- Fully automated column-based SPE with precise, gravimetric or volumetric fraction collection and real-time pressure monitoring to prevent channel clogging or breakthrough.
- Dual-concentrator module featuring two independent, temperature-controlled evaporation cups—enabling staggered or simultaneous concentration of up to 124 samples per run with minimal cross-contamination risk.
- Multi-solvent delivery system supporting eight preloaded solvents with programmable gradient elution, valve-switching logic, and solvent waste management via sealed, vented reservoirs.
- Borosilicate glass fluid path throughout all wetted components—including SPE manifolds, concentrator cups, and transfer lines—ensuring chemical compatibility with aggressive organic solvents (e.g., DCM, acetone, hexane) and minimizing adsorptive losses.
- Modular design allowing standalone use of SPE (PrepElite-GVS module) or concentrator units; seamless integration with LC/GC autosamplers via standardized vial racks (12 × 8 array, 1.5–2 mL vials).
- 24/7 unattended operation enabled by sealed chamber architecture, integrated leak detection, and automated error recovery routines—including repositioning after power interruption.
Sample Compatibility & Compliance
The PrepElite-SV accommodates diverse sample formats including liquid extracts (e.g., QuEChERS supernatants), homogenized tissue suspensions, and filtered aqueous environmental extracts. Its 1–6 mL loading range and multi-channel SPE capability support both single-analyte quantitation and multi-residue screening workflows. All hardware and software comply with GLP/GMP operational prerequisites: audit trail logging (user actions, method parameters, timestamps), electronic signature support, and secure data storage aligned with FDA 21 CFR Part 11 requirements. Instrument qualification documentation—including IQ/OQ/PQ templates—is provided for laboratory validation under ISO/IEC 17025 and CAP-accredited environments.
Software & Data Management
Controlled via LabTech’s PrepElite Suite v4.x, the platform offers dual-language UI (English/Chinese), method wizard-driven protocol building, and drag-and-drop sequence editor for custom workflow assembly. Software enforces parameter interlocks (e.g., flow rate vs. column bed volume), generates raw data files in .csv and .xlsx formats, and exports metadata-compatible reports compliant with LIMS integration standards (ASTM E1578, ANSI/NIST ITL 12-1). All method files are digitally signed and version-controlled; historical run logs include pressure traces, solvent consumption metrics, and evaporative loss curves for traceability.
Applications
- Multi-residue pesticide analysis in fruits, vegetables, grains, and animal feed per EU MRL regulations.
- Fatty acid methyl ester (FAME) purification and concentration prior to GC-FID analysis.
- PAH and PCB cleanup from soil/sediment extracts using silica or Florisil cartridges.
- Pharmaceutical impurity isolation from plasma or urine matrices using mixed-mode cation/anion exchange sorbents.
- Myco-toxin enrichment (e.g., aflatoxins, ochratoxin A) from cereal extracts with immunoaffinity columns.
FAQ
Can the PrepElite-SV be validated for regulated pharmaceutical testing?
Yes—it supports full 21 CFR Part 11 compliance with role-based access control, electronic signatures, and immutable audit trails required for FDA-submitted studies.
Is method transfer possible between PrepElite-SV and other LabTech SPE platforms?
Method parameters (flow rates, solvent sequences, timing) are exportable and compatible with PrepElite-GVS and AutoTrace systems, enabling cross-platform harmonization.
What maintenance intervals are recommended for long-term reliability?
Daily solvent line purge, monthly manifold inspection, and biannual calibration of flow sensors and temperature probes—documented in the included PM checklist.
Does the system support non-standard vial sizes or custom rack configurations?
Yes—rack geometry and position mapping are user-definable in software; LabTech provides engineering support for OEM rack fabrication.
How is solvent vapor managed during concentration?
A dedicated condenser unit cools vapors to ≤5°C, returning >95% of solvent (e.g., acetonitrile, ethyl acetate) to a recovery reservoir for reuse or safe disposal.
