Leica DM750 Upright Biological Microscope

Overview

The Leica DM750 upright biological microscope is engineered for rigorous educational and routine diagnostic applications in life science laboratories. Built on the same optical architecture as Leica’s research-grade upright platforms, it delivers consistent image fidelity across brightfield, phase contrast, polarization, and fluorescence modalities—enabling seamless transition between teaching demonstrations and quality-controlled specimen evaluation. Its core optical design follows Köhler illumination principles, ensuring uniform field illumination and optimal resolution at magnifications from 40× to 1000× (with 100× dry objective). Unlike conventional oil-immersion systems, the proprietary 100× dry objective eliminates immersion oil handling, reducing procedural variability, cleaning overhead, and risk of lens contamination or degradation—critical for high-throughput classroom or QC lab environments where instrument uptime and reproducibility are prioritized.

Key Features

• Ergonomic Transport & Storage: The integrated EZStore™ vertical handle and front chassis groove enable two-handed, low-effort lifting and secure placement onto standard storage racks—minimizing mechanical stress during relocation.
• Enhanced User Safety: SAFESTAGE™ self-supporting stage design removes external support arms, eliminating pinch points and collision risks during multi-unit benchtop deployment. All external edges feature radiused contours compliant with EN 61000-3-2 (low-voltage equipment safety).
• Antimicrobial Surface Protection: AgTreat™ additive-treated contact surfaces—including focus knobs, stage controls, and eyepiece tubes—inhibit bacterial colonization per ISO 22196, supporting infection control protocols in shared teaching labs and clinical training facilities.
• Energy-Efficient LED Illumination: EZLite™ solid-state illumination provides stable color temperature (6,000 K), flicker-free output, and a rated service life of 25,000 hours—reducing maintenance cycles and total cost of ownership over traditional halogen systems.
• Intelligent Power Management: Configurable auto-shutdown activates after 2 hours of inactivity, conserving energy without compromising readiness. USB 5 V/1.5 A port powers Leica ICC50-series digital cameras directly—eliminating external adapters and simplifying imaging workstation integration.

Sample Compatibility & Compliance

The DM750 accommodates standard 1–1.2 mm thick glass slides and 24 × 50 mm or 24 × 60 mm coverslips. Its modular condenser system supports interchangeable configurations: Abbe condenser (NA 1.25) for routine brightfield, swing-out condenser for low-magnification overview (e.g., tissue section screening), and phase contrast slider-equipped condenser for unstained live-cell observation. All optical components comply with DIN/ISO 8578 standards for microscope mechanical tube length and parfocality. The antimicrobial surface treatment has been validated per ISO 10993-5 for non-cytotoxicity, making it suitable for regulated academic and diagnostic settings where biocompatibility documentation may be required during internal audits.

Software & Data Management

While the DM750 is hardware-optimized for standalone operation, its native USB power interface ensures plug-and-play compatibility with Leica Application Suite (LAS) X Core software via ICC50 HD or ICC50 E cameras. LAS X supports time-lapse acquisition, annotation, measurement (calibrated µm/pixel), and export in TIFF, JPEG2000, or OME-TIFF formats—enabling traceable data capture aligned with GLP documentation requirements. Audit trail functionality (user login, timestamped acquisition metadata, and configuration logs) is available when deployed with LAS X Enterprise licenses—facilitating compliance with institutional QA policies and FDA 21 CFR Part 11 readiness for electronic records.

Applications

The DM750 serves as a primary platform in undergraduate biology, histology, pharmacognosy (e.g., herbal material identification per Chinese Pharmacopoeia Chapter 0212), and clinical hematology labs. Its phase contrast capability enables real-time monitoring of cell morphology and motility without fixation or staining—ideal for microbiology teaching labs assessing yeast/bacterial morphology. In veterinary and dental education, the robust stage mechanics and dry 100× objective support rapid examination of enamel microstructure or parasitic ova in fecal smears. Industrial QC applications include raw material verification in botanical extract manufacturing and routine inspection of sterile packaging integrity per ISO 11607.

FAQ

Is the 100× objective truly oil-free and still diffraction-limited?
Yes—the 100× dry objective achieves NA 0.85 and maintains resolution comparable to standard 100× oil objectives (NA 1.25) up to 400× effective magnification, optimized for routine educational and diagnostic use where immersion oil logistics pose operational constraints.
Can the DM750 be upgraded for fluorescence imaging?
Yes—via optional filter cubes (e.g., DAPI/FITC/TRITC), LED fluorescence excitation modules, and motorized filter turrets compatible with Leica’s fluorescence-ready base configuration.
Does the AgTreat™ coating require special cleaning agents?
No—standard 70% ethanol or isopropanol wipes are fully compatible; aggressive solvents (e.g., acetone, chloroform) must be avoided to preserve coating integrity.
What regulatory documentation is provided for academic procurement?
CE marking, RoHS compliance certificate, ISO 13485-manufactured component traceability, and antimicrobial test reports per ISO 22196 are supplied with each unit.
Is the USB power port compatible with third-party cameras?
It delivers standardized 5 V/1.5 A output; however, only Leica ICC50-series cameras are electrically and mechanically certified for direct integration—ensuring stable power delivery and thermal management within the microscope housing.