Masterflex L/S Multi-Channel Clamp Pump Head (4- and 8-Channel)

Overview

The Masterflex^® L/S Multi-Channel Clamp Pump Head (Model 07519-05) is a precision-engineered peristaltic pump head designed for simultaneous, independent fluid handling across up to eight discrete channels. Based on the well-established L/S series architecture from Masterflex — a division of Cole-Parmer — this clamp-style pump head operates via positive displacement through occlusion of elastomeric tubing by rotating rollers mounted on a stainless steel rotor. Its modular clamp design enables flexible configuration for parallel processing in applications requiring high channel count, reproducible flow control, and rapid tubing changeover without mechanical disassembly from the drive unit. The pump head is optimized for compatibility with standard L/S-series tubing (e.g., L/S 13, L/S 14, L/S 16, L/S 25, L/S 17) and microbore dual-clamp tubing (ID 0.89–2.79 mm), supporting flow rates from sub-microliter-per-minute dispensing to high-throughput transfer at up to 1700 mL/min — depending on tubing selection, rotational speed, and roller count.

Key Features

• Modular clamp architecture supports scalable channel deployment: 1–8 small clamps or 1–4 large clamps per head, including mixed-size configurations on a single platform.
• Tool-free, plug-and-play clamp insertion ensures rapid tubing replacement — no need to detach the pump head from the drive motor.
• O-ring-assisted alignment guarantees accurate, repeatable clamp positioning even when not fully seated — critical for maintaining consistent occlusion geometry and minimizing flow variability.
• Stainless steel rotor and polysulfone (PSF) housing provide chemical resistance, dimensional stability, and long-term mechanical integrity under continuous operation.
• Adjustable tangent occlusion geometry with precision-machined bearing surfaces ensures uniform compression and reduced tubing fatigue — extending service life in demanding conditions (e.g., elevated pressure, high RPM, abrasive or viscous fluids).
• Available in 3-roller (Model 07519-05) and 4-roller (Model 07519-06) variants; increased roller count reduces pulsation amplitude and improves flow smoothness, particularly at low flow rates and high viscosities.

Sample Compatibility & Compliance

The 07519-05 pump head accommodates a broad range of certified tubing materials, including platinum-cured silicone, Pharmed^® BPT, Tygon^® 3603, and Viton^®, each selected for specific chemical compatibility, biocompatibility, or regulatory suitability. Tubing inner diameters span 0.89 mm to 2.79 mm for dual-clamp configurations and L/S sizes 13–17 for standard peristaltic use. When paired with validated tubing and operated within specified speed and occlusion parameters, the system meets requirements for GLP-compliant liquid handling and supports audit-ready documentation under FDA 21 CFR Part 11 when integrated with compliant drive controllers and software. It conforms to ISO 8536-4 (infusion equipment) mechanical interface guidelines and is routinely deployed in environments adhering to ASTM D1248 (polymer tubing standards) and USP (elastomeric components for pharmaceutical use).

Software & Data Management

While the 07519-05 is a passive pump head requiring external drive integration, it is fully compatible with Cole-Parmer’s Masterflex I/P and I/P Plus digital drives — which support programmable ramp profiles, real-time flow calibration, bidirectional operation, and RS-232/USB/Ethernet communication. When used with Masterflex FlowCal™ software or third-party SCADA/HMI platforms (e.g., LabVIEW, Ignition), users can implement automated multi-channel sequencing, dose accuracy validation, and electronic batch records. Audit trails, user access controls, and parameter lockout features align with GMP data integrity expectations. The pump head itself contains no embedded electronics — ensuring electromagnetic compatibility (EMC) and simplifying qualification in regulated labs.

Applications

• Parallel reagent dispensing in high-throughput screening (HTS) and assay development.
• Multi-stream media feeding in bioreactors and fermentation systems.
• Simultaneous sampling and dilution in environmental water analysis (e.g., EPA Method 300.0).
• Controlled gradient delivery in preparative chromatography and fraction collection.
• Cell culture perfusion systems requiring independent flow control per inlet/outlet line.
• Pharmaceutical process development where segregation of fluid paths prevents cross-contamination between batches or formulations.

FAQ

What drive specifications are required to operate the 07519-05 pump head?
A minimum 0.1 hp (75 W) AC or DC drive capable of 0.02–600 rpm is required. Compatible models include Masterflex I/P, I/P Plus, and certain Ismatec IPC series drives.
Can small and large clamps be installed simultaneously on one pump head?
Yes — the mounting footprint allows hybrid configurations, where each large clamp occupies the space of two small clamps, enabling customized channel density without sacrificing flow range flexibility.
Which tubing types are validated for use with L/S 17 tubing on this pump head?
L/S 17 tubing (ID ≈ 3.2 mm) requires large clamps (Cat. No. 07519-70) and is compatible only with silicone or C-Flex^® tubing — not standard Tygon or Pharmed due to wall thickness and compression profile constraints.
How does roller count affect flow performance?
A 4-roller configuration (e.g., 07519-06) reduces flow pulsation by ~30% compared to 3-roller designs at equivalent speeds and tubing, improving accuracy in low-flow (<1 mL/min) and shear-sensitive applications.
Is the pump head suitable for sterile or cleanroom use?
Yes — the PSF housing is autoclavable (121°C, 20 min, 15 psi), and the clamp assembly supports SIP (steam-in-place) protocols when installed with appropriate tubing and seals. Surface finish complies with ISO 14644-1 Class 7 (10,000) particulate limits when cleaned per SOP.