METTLER TOLEDO EasyViewer In-line Imaging and Particle Size Analyzer
| Brand | METTLER TOLEDO |
|---|---|
| Origin | USA |
| Manufacturer Type | Authorized Distributor |
| Origin Category | Imported |
| Model | EasyViewer |
| Pricing | Upon Request |
| Viewing Field | 1 mm × 1 mm |
| Resolution Accuracy | 1.5 µm |
| Fiber Optic Cable Length | 3 m (standard), 13 m (with USB extender) |
| Weight | 0.66 kg (probe + fiber assembly) |
| Probe Operating Temperature | −20 °C to 135 °C |
| Maximum Pressure Rating | 0–10 bar |
| Probe Housing Material | Hastelloy C-22 |
Overview
The METTLER TOLEDO EasyViewer is an in-line, probe-based imaging sensor engineered for real-time, in-situ characterization of particles, crystals, and droplets within industrial process streams. Unlike offline or sampling-dependent techniques, EasyViewer employs high-resolution optical microscopy coupled with fiber-optic transmission to deliver direct visual access to dynamic particulate systems without process interruption. Its measurement principle relies on digital image acquisition at the point of interest—enabling quantification of particle size distribution (PSD), particle count, morphological descriptors (e.g., circularity, aspect ratio, convexity), and interfacial behavior under actual process conditions. Designed specifically for continuous manufacturing environments, it supports regulatory-compliant process understanding per ICH Q5, Q8, and Q9 frameworks, and aligns with FDA’s Process Analytical Technology (PAT) initiative for enhanced quality assurance.
Key Features
- In-line probe architecture with minimal intrusion: 12 mm outer diameter stainless-steel–clad housing compatible with standard sanitary or threaded process connections.
- Auto-focus control algorithm ensures consistent image sharpness across varying suspension densities and refractive index gradients.
- Hastelloy C-22 probe body provides chemical resistance to aggressive media including strong acids, caustics, and organic solvents—validated for use in API synthesis, bioprocessing, and fine chemical applications.
- Operating range spans −20 °C to 135 °C and up to 10 bar pressure, supporting both ambient and elevated-T/P crystallization, emulsification, and precipitation operations.
- Modular fiber-optic interface (standard 3 m; extended 13 m with active USB repeater) enables flexible installation in confined or hazardous locations while maintaining signal integrity.
- Zero-sample-prep requirement eliminates analytical bias from filtration, dilution, or drying artifacts—critical for high-solid-content slurries (>40 wt%) and viscous emulsions.
Sample Compatibility & Compliance
EasyViewer is validated for multiphase systems including solid–liquid (e.g., crystallizing APIs), liquid–liquid (e.g., pharmaceutical emulsions, polymer dispersions), and solid–gas (e.g., fluidized bed granulation aerosols). It operates reliably in opaque, highly scattering media where laser diffraction or light obscuration methods fail. The system meets mechanical integrity requirements per ASME B31.4 and PED 2014/68/EU for pressure equipment integration. Data traceability complies with 21 CFR Part 11 when deployed with iC-Vision software configured for electronic signatures, audit trails, and role-based access control—supporting GLP/GMP-aligned workflows in regulated development and manufacturing.
Software & Data Management
Integrated exclusively with METTLER TOLEDO’s iC-Vision software, EasyViewer delivers calibrated image analysis using ISO 13322-1 compliant segmentation algorithms. iC-Vision provides batch-wise trend reporting of median particle size (x₅₀), number-weighted distribution, shape factor evolution, and endpoint detection via multivariate pattern recognition. All raw images and metadata are stored in a secure, time-stamped database with version-controlled processing parameters. Export options include CSV, PDF reports, and OPC UA connectivity for MES/DCS integration. Software validation documentation (IQ/OQ/PQ protocols) is available for qualification in regulated environments.
Applications
- Crystallization process monitoring: Detect nucleation onset, monitor crystal growth kinetics, and identify agglomeration or breakage events during cooling/antisolvent addition.
- Emulsion stability assessment: Quantify droplet coalescence, Ostwald ripening, and phase inversion in real time during homogenization or storage.
- Fouling and deposition studies: Visualize particle accumulation on heat exchanger surfaces or filter membranes under flow conditions.
- Polymerization reaction control: Track latex particle formation and size narrowing in dispersion polymerization reactors.
- Wet granulation endpoint determination: Correlate granule morphology changes with torque and moisture profiles in high-shear mixers.
FAQ
Can EasyViewer be used in sterile bioprocessing applications?
Yes—its probe design supports SIP (steam-in-place) up to 135 °C and autoclave compatibility; contact METTLER TOLEDO for validated sterilization cycle protocols.
Does it require calibration with reference standards?
No routine calibration is needed; resolution accuracy (1.5 µm) is factory-verified using NIST-traceable micrometer targets and maintained via fixed optical path geometry.
How does it handle highly turbid or air-entrained slurries?
The coaxial illumination and short working distance minimize scattering artifacts; contrast enhancement algorithms in iC-Vision improve segmentation robustness in low-SNR conditions.
Is third-party software integration supported?
Yes—via RESTful API and OPC UA server mode, enabling bidirectional data exchange with DeltaV, Emerson DCS, or custom LIMS platforms.
What maintenance is required?
Annual inspection of fiber-optic connector cleanliness and probe window integrity; no consumables or moving parts require replacement under normal operation.
