METTLER TOLEDO InMotion Automated Sample Changer for Potentiometric Titrators

Overview

The METTLER TOLEDO InMotion Automated Sample Changer is an engineered solution for high-throughput, unattended potentiometric titration workflows. It operates as a modular peripheral device integrated with METTLER TOLEDO’s family of automatic potentiometric titrators—including the T50, T70, T90, and Excellence series—enabling precise, repeatable sample handling under programmable control. The system employs a motorized, indexed turntable architecture that positions samples sequentially beneath the titration burette and electrode assembly. Its core function is to eliminate manual intervention during sample loading, reagent addition, electrode rinsing, and waste disposal—thereby reducing operator variability, transcription errors, and exposure to hazardous chemicals. Designed for laboratories performing routine quality control (QC), raw material testing, or regulatory-compliant release assays, InMotion ensures traceability, reproducibility, and operational continuity across multi-shift or overnight runs.

Key Features

• Modular turntable configurations supporting up to 300 sample positions—scalable via Flex, Pro, Max, and Water-Bath turntable kits (order numbers 30094124–30094141)
• PowerShower™ dynamic rinse system delivering targeted, high-velocity solvent jets to clean electrodes between analyses—minimizing carryover and cross-contamination
• Programmable immersion wash cycle for thorough electrode cleaning in dedicated rinse beakers
• Optional CoverUp™ automated lid actuation system for enhanced operator safety and sample integrity in volatile or hygroscopic applications
• Integrated temperature-controlled water-bath turntable (Flex and Pro variants) enabling precise thermal management of samples from 5 °C to 40 °C
• Plug-and-play connectivity with tiamo™ titration software for synchronized method execution, real-time status monitoring, and error logging
• Compact footprint (≤ 600 × 450 mm base area) optimized for standard laboratory benchtop integration without sacrificing capacity

Sample Compatibility & Compliance

InMotion accommodates a broad range of titration vessel geometries—from 10 mL micro-cups to 250 mL wide-mouth beakers—via standardized adapter rings and magnetic retention fixtures. It supports aqueous, non-aqueous, and mixed-solvent systems common in acid-base, redox, precipitation, and complexometric titrations. All mechanical and fluidic components comply with ISO 8573-1 (compressed air purity) and IEC 61326-1 (EMC for laboratory equipment). When deployed with tiamo™ software configured for 21 CFR Part 11 compliance, the system provides full audit trail functionality—including user authentication, electronic signatures, method versioning, and immutable data archiving—meeting requirements for pharmaceutical QC labs operating under USP , EP 2.2.42, and ISO/IEC 17025 accreditation frameworks.

Software & Data Management

InMotion is fully controlled through METTLER TOLEDO’s tiamo™ software platform (v3.3 or later), which provides a graphical method editor for defining multi-step sequences: sample identification, pre-titration stirring, endpoint detection parameters, post-titration rinsing, and result calculation (e.g., % purity, mg KOH/g, mmol/L). Raw titration curves, derivative plots, and metadata (timestamp, operator ID, instrument ID, environmental conditions) are stored in encrypted .tia binary format and exportable to CSV, PDF, or LIMS-compatible XML. The software enforces role-based access control (RBAC), supports electronic batch records (EBR), and logs all critical events—including door openings, power interruptions, and calibration interventions—for full process accountability.

Applications

• Pharmaceutical raw material assay (e.g., active pharmaceutical ingredient quantification per USP monographs)
• Fatty acid value (AV) and peroxide value (PV) determination in edible oils per AOAC 965.33 and ISO 3960
• Chloride content analysis in cement, wastewater, and brine solutions using argentometric titration
• Acid number and base number measurement in lubricants and transformer oils (ASTM D974, D664)
• Calcium and magnesium hardness profiling in drinking water and industrial process streams
• Quality assurance of food-grade acids, bases, and preservatives across dairy, beverage, and confectionery production lines

FAQ

Can InMotion be retrofitted to existing METTLER TOLEDO titrators?
Yes—InMotion is compatible with all current-generation METTLER TOLEDO potentiometric titrators (T50/T70/T90 and Excellence series) via standard RS-232 or Ethernet interface; firmware update and configuration via tiamo™ are required.
Does InMotion support dual-electrode or pH/mV dual-mode titrations?
Yes—when paired with a dual-channel titrator (e.g., T90), InMotion enables sequential or parallel titrations using independent electrode sets, each with dedicated rinse protocols.
Is validation documentation available for GxP environments?
METTLER TOLEDO provides IQ/OQ protocol templates, risk assessments, and traceability matrices aligned with ASTM E2500 and Annex 11; site-specific PQ must be executed by the end user.
What maintenance intervals are recommended for the PowerShower™ system?
Daily visual inspection of nozzles; quarterly ultrasonic cleaning of rinse manifolds; annual replacement of peristaltic pump tubing and O-rings per preventive maintenance schedule.
Can custom sample racks be fabricated for non-standard vessels?
Yes—METTLER TOLEDO offers engineering consultation and CAD-supported custom fixture design for proprietary container formats, subject to mechanical feasibility review.