METTLER TOLEDO MA204 Analytical Balance

Overview

The METTLER TOLEDO MA204 Analytical Balance is a precision laboratory instrument engineered for high-accuracy mass determination in regulated and research-intensive environments. Operating on electromagnetic force compensation (EMFC) principle, the MA204 delivers stable, drift-resistant measurements under variable ambient conditions—critical for applications requiring traceable, repeatable results. With a maximum capacity of 220 g and readability of 0.1 mg, it meets the performance criteria defined in ISO 17025 for accredited testing laboratories and aligns with USP requirements for analytical balance qualification. Its robust mechanical architecture—including a die-cast metal base, integrated draft shield, and overload protection—ensures long-term stability and resistance to mechanical shock, thermal drift, and environmental contamination.

Key Features

• Electromagnetic force compensation sensor delivering high linearity and minimal hysteresis across the full range.
• Internal calibration system with motorized calibration mass, enabling automated recalibration at user-defined intervals or upon temperature drift detection.
• High-contrast LCD display with enlarged digit height (≥12 mm), optimized for ergonomic viewing and reduced operator fatigue during extended use.
• RS232 serial interface supporting bidirectional communication with external peripherals—including label printers, secondary displays, and LIMS or ELN systems—without requiring additional adapters.
• Dedicated below-balance weighing hook integrated into the lower housing, enabling suspension of oversized, volatile, or thermally sensitive samples without compromising measurement integrity.
• Configurable user lockout function to restrict access to setup parameters (e.g., unit selection, auto-zero threshold, stabilization time), ensuring procedural consistency across multiple operators and shifts.
• Preloaded application modes: piece counting (with automatic average piece weight calculation), dynamic weighing (for unstable samples), and percent weighing—each compliant with GLP documentation requirements.

Sample Compatibility & Compliance

The MA204 accommodates a broad spectrum of sample types—from powders and granules to small metallic components and sealed vials—within its 220 g capacity and 120 mm diameter weighing pan. The included draft shield mitigates convective air currents and static interference, essential for low-mass measurements (<100 mg). All firmware and hardware configurations comply with IEC 61326-1 (EMC for laboratory equipment) and IEC 61010-1 (safety requirements for electrical equipment). For regulated industries, the balance supports audit trail generation (via optional software), meets FDA 21 CFR Part 11 readiness when paired with METTLER TOLEDO LabX™, and satisfies ISO/IEC 17025 clause 6.4.7 regarding equipment verification and traceability.

Software & Data Management

While the MA204 operates autonomously via front-panel controls, its RS232 port enables seamless integration into digital workflows. Raw weighing data—including timestamp, net/gross/tare values, and application mode identifier—can be streamed directly to spreadsheets, databases, or validated laboratory informatics platforms. When connected to METTLER TOLEDO’s LabX software (sold separately), the device supports full electronic record retention, user authentication, electronic signatures, and automated report generation—all aligned with ALCOA+ data integrity principles. All data exports are ASCII-formatted and include checksum validation to ensure transmission fidelity.

Applications

The MA204 serves as a foundational tool in pharmaceutical quality control (e.g., active pharmaceutical ingredient (API) assay, excipient blending verification), chemical synthesis (reagent dosing, stoichiometric ratio validation), materials science (coating thickness calculation via mass loss), and academic research (calorimetry sample preparation, nanomaterial dispersion quantification). Its repeatability of ±0.08 mg supports method validation per ICH Q2(R2), while its internal calibration routine fulfills periodic verification requirements outlined in ASTM E898 and EURACHEM/CITAC Guide CG4.

FAQ

What is the recommended calibration frequency for the MA204 in a GMP environment?
Calibration should occur at the start of each shift, after relocation, and following any event that may affect accuracy (e.g., temperature fluctuation >2°C, mechanical impact). Internal calibration must be verified annually against traceable external standards.
Does the MA204 support GLP-compliant data export?
Yes—when configured with appropriate metadata fields and connected to a validated data capture system, all exported records include operator ID, timestamp, balance ID, and environmental conditions (if monitored externally).
Can the draft shield be removed for cleaning without affecting calibration?
Yes—the shield is mechanically decoupled from the sensor assembly; removal and reinstallation do not require recalibration, though routine verification is advised post-cleaning.
Is the RS232 interface compatible with modern Windows/macOS systems?
Yes—using standard USB-to-RS232 adapters with FTDI or Prolific chipsets, the interface maintains full protocol compatibility with terminal emulators and custom Python/Node.js data acquisition scripts.
What maintenance is required beyond routine cleaning and calibration?
Annual preventive maintenance by an authorized METTLER TOLEDO service technician is recommended to inspect sensor alignment, verify electromagnetic coil integrity, and update firmware to address security patches and compliance enhancements.