METTLER TOLEDO XPR105DUE/AC Advanced Analytical Balance

Overview

The METTLER TOLEDO XPR105DUE/AC is a high-performance dual-range analytical balance engineered for precision mass measurement in regulated laboratory environments. Utilizing electromagnetic force compensation (EMFC) technology, it delivers traceable, stable, and highly reproducible results across two distinct weighing ranges: 220 g at 0.1 mg readability and 81 g at ultra-fine 0.01 mg readability. This dual-range architecture enables seamless transition between routine QC checks and high-sensitivity applications—such as active pharmaceutical ingredient (API) assay, reference standard preparation, or low-mass formulation—without requiring instrument reconfiguration or recalibration. Its robust mechanical design incorporates an advanced monolithic weighing cell, vibration-damped base, and optimized air draft shielding to maintain metrological integrity under variable ambient conditions. The balance meets the fundamental metrological requirements of ISO/IEC 17025, OIML R 76, and EURAMET cg-18, and is validated for use in GLP and GMP workflows where measurement uncertainty, traceability, and audit readiness are mandatory.

Key Features

• Dual-range capability: Simultaneous 220 g @ 0.1 mg and 81 g @ 0.01 mg readability—optimized for both throughput and resolution.
• FACT (Fully Automatic Calibration Technology): Internal motor-driven calibration weights enable temperature-compensated, time-triggered or event-driven recalibration without user intervention.
• 7-inch full-color TFT touchscreen with intuitive icon-based navigation and multi-touch gesture support—designed for gloved operation and rapid method execution.
• Comprehensive user management system supporting unlimited accounts with configurable roles (e.g., operator, supervisor, administrator), password enforcement, and session timeout.
• Integrated environmental monitoring: Real-time display of ambient temperature and draft status to support root-cause analysis of weighing variability.
• Modular connectivity: Standard USB-A (for printers/storage), USB-B (for PC/LabX integration), and Ethernet; optional RS232 and Bluetooth modules for legacy or mobile device interoperability.

Sample Compatibility & Compliance

The XPR105DUE/AC accommodates standard analytical sample vessels—including vials, crucibles, weighing boats, and filter papers—on its 78 mm × 73 mm stainless-steel pan. Its compact footprint and vertical airflow design minimize turbulence-induced drift, making it suitable for open-bench use in shared lab spaces. From a regulatory standpoint, the balance is prequalified for compliance with USP (balances) and (weighing procedures), and supports full 21 CFR Part 11 compliance when operated with METTLER TOLEDO LabX software—including electronic signatures, audit trail generation, and secure data archiving. It satisfies critical GxP data integrity principles (ALCOA+), and its firmware is designed to meet IEC 62304 Class B software safety requirements.

Software & Data Management

While functional as a standalone instrument, the XPR105DUE/AC achieves full digital workflow integration via LabX laboratory software. LabX provides centralized method deployment, real-time data capture, automated calculations (e.g., % recovery, dilution factors), and seamless export to LIMS or ERP systems. All balance events—including weighings, calibrations, diagnostics, and user logins—are timestamped, digitally signed, and stored in an immutable audit trail. Data encryption (AES-256), role-based access control, and periodic backup scheduling ensure long-term data security and regulatory defensibility. Optional features include remote monitoring via LabX Web Server and integration with MES platforms through OPC UA.

Applications

• Pharmaceutical: Quantitative assay of potent compounds, reference standard weighing, content uniformity testing, and stability-indicating method development.
• Chemical R&D: Precise stoichiometric reagent dispensing, catalyst loading, and gravimetric preparation of calibration standards.
• Food & Beverage: Nutrient labeling compliance (e.g., vitamin fortification), moisture content determination (via loss-on-drying protocols), and raw material verification.
• Academic & Contract Labs: Teaching quantitative analytical techniques, inter-laboratory comparison studies, and ISO/IEC 17025 method validation.

FAQ

What does “DUE/AC” signify in the model number?
The “DUE” denotes dual-range electromagnetic force compensation technology, while “AC” indicates AC-powered operation with integrated power supply and universal voltage compatibility (100–240 V AC).
Is the XPR105DUE/AC suitable for USP minimum weight verification?
Yes—its certified repeatability of 0.01 mg and documented minimum weight of 20 mg (at 0.1% tolerance) satisfy USP criteria for analytical balances used in pharmaceutical manufacturing and quality control.
Does the balance support GLP-compliant documentation without LabX?
Basic GLP functions (e.g., user login, calibration logs, date/time stamps) are embedded in firmware; however, full audit trail, electronic signature, and report generation require LabX software.
Can the touchscreen be cleaned with ethanol or isopropyl alcohol?
Yes—the chemically strengthened glass surface is resistant to common laboratory disinfectants, including 70% IPA and diluted ethanol solutions, per METTLER TOLEDO’s cleaning guidelines.
What is the purpose of the “leveling guide” function?
The built-in leveling assistant uses an integrated inclinometer and on-screen visual feedback to guide users through precise horizontal alignment—critical for maintaining accuracy and meeting ISO 14405 geometric tolerance requirements.