METTLER TOLEDO XPR204DUE/AC Advanced Analytical Balance

Overview

The METTLER TOLEDO XPR204DUE/AC is a high-performance analytical balance engineered for precision mass measurement in regulated laboratory environments. Utilizing electromagnetic force compensation (EMFC) technology, it delivers exceptional accuracy, repeatability, and long-term stability across dual weighing ranges—220 g at 1 mg readability and 121 g at 0.1 mg readability—enabling seamless transition between routine and ultra-sensitive applications. Designed and manufactured in Switzerland, the XPR204DUE/AC belongs to the XPR Essential series, integrating core metrological rigor with intuitive human-machine interaction. Its 7-inch full-color TFT touchscreen provides real-time feedback, contextual guidance, and visual confirmation of critical operational states—including level status, draft shield integrity, and calibration readiness. The balance meets stringent international standards for analytical instrumentation, including USP for minimum weight determination, ISO/IEC 17025 for testing and calibration laboratories, and supports full compliance with Good Manufacturing Practice (GMP), Good Laboratory Practice (GLP), and FDA 21 CFR Part 11 when used with LabX software.

Key Features

• Electromagnetic force compensation sensor with active temperature control for drift-free performance
• Dual-range capability: 220 g @ 1 mg and 121 g @ 0.1 mg—optimized for flexibility without sacrificing resolution
• FACT (Fully Automatic Calibration Technology) with internal motorized weights ensures traceable, time-triggered or event-driven recalibration
• Intelligent level guidance system with on-screen tilt visualization and step-by-step leveling instructions
• Integrated static detection algorithm (optional add-on) identifies electrostatic interference and prompts mitigation steps
• Robust aluminum die-cast housing with chemical-resistant surface coating for durability in demanding QC and R&D settings
• Modular connectivity architecture supporting RS232, dual USB ports (host and device), Gigabit Ethernet, and optional Bluetooth for peripheral integration

Sample Compatibility & Compliance

The XPR204DUE/AC accommodates standard analytical sample containers, crucibles, and volumetric glassware within its 78 mm × 73 mm stainless-steel weighing pan. Its compact footprint and optimized airflow design minimize turbulence under draft shields, ensuring stable readings even for low-mass, high-surface-area samples (e.g., lyophilized powders, reference standards, catalysts). Regulatory alignment includes built-in support for USP minimum weight verification protocols, automatic calculation of uncertainty-based minimum weight (k = 2, U = 1%), and audit-ready logging of all weighing events. The balance is certified for use in pharmaceutical manufacturing (ICH Q7), chemical synthesis QA/QC, and food safety testing labs operating under ISO 22000 and HACCP frameworks.

Software & Data Management

When paired with METTLER TOLEDO LabX™ software, the XPR204DUE/AC enables full 21 CFR Part 11 compliance—including electronic signatures, user authentication, audit trails with immutable timestamps, and role-based access control. All raw data, metadata (operator ID, timestamp, environment logs), and result calculations are stored centrally and exportable in secure, tamper-evident formats (PDF/A, CSV, XML). Built-in method templates allow standardized workflows for assay preparation, content uniformity testing, or residual solvent quantification—reducing manual transcription errors and accelerating SOP execution. Local touchscreen operation also supports offline use with synchronized data upload upon network reconnection.

Applications

• Pharmaceutical: Active pharmaceutical ingredient (API) assay, reference standard weighing, dissolution test sample preparation, and excipient blending verification
• Chemical R&D: Stoichiometric reagent dispensing, catalyst loading, and reaction yield quantification
• Food & Beverage: Nutrient labeling compliance (e.g., vitamin fortification), moisture content analysis by loss-on-drying, and allergen cross-contamination assessment
• Academic & Contract Labs: Teaching metrology principles, inter-laboratory proficiency testing, and ISO/IEC 17025 method validation studies
• Regulatory Audits: Real-time documentation of weighing processes during FDA, EMA, or PMDA inspections

FAQ

Does the XPR204DUE/AC meet USP requirements for minimum weight determination?

Yes—the balance calculates and displays both statistical minimum weight (U = 1%, k = 2) and pharmacopeial minimum weight (USP , 0.1% tolerance) in real time during setup.
Is FACT calibration traceable to national standards?

Yes—internal calibration weights are factory-certified and traceable to SI units via METTLER TOLEDO’s accredited calibration laboratory (ISO/IEC 17025 accredited).
Can multiple users be assigned distinct permission levels?

Yes—LabX software supports hierarchical user roles (e.g., operator, supervisor, administrator) with configurable access to methods, reports, and system settings.
What environmental conditions affect repeatability?

Air currents, temperature gradients >0.5 °C/h, and electrostatic charge accumulation are primary influencers; the balance includes diagnostics for each and recommends mitigation strategies.
Is the touchscreen compatible with gloved operation?

Yes—the capacitive display supports operation with standard nitrile and latex gloves, and haptic feedback confirms input registration.