METTLER TOLEDO XPR226DRQ Automated Dispensing Balance
| Key | Brand: METTLER TOLEDO |
|---|---|
| Origin | Switzerland |
| Model | XPR226DRQ |
| Type | Analytical Balance |
| Max Capacity | 220 g |
| Readability | 2 µg |
| Accuracy | 5 µg |
| Repeatability | 0.01 mg |
| Calibration | Internal motorized calibration |
| Application | Automated gravimetric dispensing and quantitative sample preparation |
Overview
The METTLER TOLEDO XPR226DRQ Automated Dispensing Balance is an ultra-micro analytical balance engineered for fully automated, gravimetric solid and liquid dispensing in regulated and research-intensive laboratory environments. Unlike conventional manual or semi-automated weighing systems, the XPR226DRQ integrates high-resolution mass measurement (2 µg readability) with precision mechanical dispensing actuators and real-time feedback control—enabling closed-loop, loss-in-weight (LIW) or gain-in-weight (GIW) dispensing directly into target containers. Its core architecture follows the principles of metrological traceability and force restoration transduction, delivering certified accuracy compliant with ISO/IEC 17025 requirements for calibration laboratories and GLP/GMP workflows. Designed specifically for applications where sample scarcity, operator safety, and regulatory documentation are critical constraints, the XPR226DRQ eliminates manual transfer steps, minimizes environmental perturbations (e.g., air currents, vibration, static), and ensures process consistency across operators and shifts.
Key Features
- 2 µg readability with 0.01 mg repeatability—validated per USP and ASTM E899 for micro-weighing performance
- Integrated high-sensitivity load cell and active damping system for stable readings in non-ideal lab environments
- Motorized internal calibration with automatic recalibration triggered by time, temperature drift, or user-defined events
- Patented SmartSens™ infrared sensor array for non-contact tare detection and container presence verification—even for vials as small as 2 mL or weighing boats under 0.5 g
- Modular dispensing head compatible with powder feeders, screw-driven augers, and liquid dosing modules for hybrid solid/liquid workflows
- Touchscreen interface with guided SOP execution, multilingual support, and role-based access control (admin/operator/auditor)
Sample Compatibility & Compliance
The XPR226DRQ accommodates a broad range of primary and secondary containers—including 1.5 mL Eppendorf tubes, 10–30 mm diameter vials, 96-well plates, and capsule shells—via interchangeable adapter kits certified for pharmaceutical capsule filling (USP ). All dispensing operations comply with FDA 21 CFR Part 11 requirements when paired with LabX software, supporting electronic signatures, audit trails, and data integrity controls (ALCOA+ principles). The balance meets IEC 61326-1 for electromagnetic compatibility and EN 61010-1 for electrical safety. It is validated for use in ISO Class 5–7 cleanrooms and supports routine verification per GWP® (Good Weighing Practice) guidelines.
Software & Data Management
When connected to METTLER TOLEDO LabX software, the XPR226DRQ functions as a networked node within a centralized laboratory data infrastructure. LabX provides full lifecycle documentation: method creation with embedded calculations (e.g., dilution factors, concentration normalization), real-time result visualization, and automatic export to LIMS, ELN, or cloud-based repositories. All metadata—including timestamp, operator ID, environmental conditions (optional sensor integration), calibration status, and raw weight values—are archived with immutable audit trails. Customizable PDF reports include digital signatures, version history, and compliance statements for internal audits or regulatory inspections (e.g., FDA, EMA, PMDA).
Applications
- Preparation of reference standards and certified reference materials (CRMs) at sub-milligram levels
- High-potency API (HPAPI) handling in early-phase drug development—reducing operator exposure to nanogram-level toxic compounds
- Automated formulation of calibration standards for ICP-MS, LC-MS/MS, and GC-MS workflows
- Gravimetric dilution series generation with ≤0.1 mg/g final concentrations and ≤10,000-fold dilution ratios in a single step
- Quality control of lyophilized products, inhalation powders, and oral solid dosage forms
- Material conservation in isotopic labeling studies, radiopharmaceutical synthesis, and rare-earth element analysis
FAQ
What is the maximum number of containers supported in a single automated run?
Up to 30 containers using the optional AutoSampler module with configurable rack geometry.
Can the XPR226DRQ dispense both solids and liquids in the same method?
Yes—when equipped with dual-module configuration (powder feeder + liquid dosing unit), it executes sequential or parallel solid/liquid addition under one SOP.
Is the balance compliant with pharmacopeial requirements for analytical balance qualification?
Yes—it supports full IQ/OQ/PQ protocols per USP , EP 2.1.6, and JP 2.03, including eccentricity, linearity, sensitivity, and repeatability testing.
How does the system handle static-sensitive or hygroscopic samples?
Optional anti-static ionizer integration and draft shield variants (e.g., XPR-DraftShield) mitigate electrostatic interference and moisture exchange during dispensing.
Does LabX support integration with enterprise systems such as SAP or Oracle?
Yes—via ODBC, REST API, or HL7 interfaces for bidirectional data exchange with ERP, MES, and quality management systems.
