METTLER TOLEDO XSR105 Precision Balance

Overview

The METTLER TOLEDO XSR105 Precision Balance is an engineered solution for high-throughput, routine laboratory and production weighing tasks requiring 1 mg readability and consistent repeatability. Built upon METTLER TOLEDO’s proven monolithic sensor architecture and electromagnetic force compensation (EMFC) technology, the XSR105 delivers stable, drift-resistant performance even under dynamic environmental conditions—such as airflow in fume hoods, mechanical vibration near production lines, or temperature fluctuations in shared lab spaces. Its core design philosophy centers on minimizing operator intervention while maximizing measurement integrity: the balance achieves reliable results without mandatory draft shielding in standard ambient conditions, significantly reducing cycle time per sample. This operational flexibility is enabled by the proprietary SmartPan™ weighing pan system—a mechanically optimized, low-profile platform that suppresses air current interference and enhances settling speed. The XSR105 is not a general-purpose scale; it is calibrated and validated for applications demanding traceable mass measurement in regulated settings, including quality control laboratories, raw material inspection, and formulation support.

Key Features

• SmartPan™ Weighing System: A patented dual-layer pan assembly consisting of a precision-machined stainless-steel weighing pan mounted above a removable, chemically inert spill containment tray. This configuration captures accidental spills beneath the active weighing surface, preventing contamination of internal load cell mechanisms and simplifying decontamination protocols.
• Draft Shield Flexibility: Engineered to operate reliably with the draft shield fully open in controlled environments such as Class II biosafety cabinets or chemical fume hoods—eliminating manual door handling and reducing ergonomic strain during repetitive weighing sequences.
• Full-Metal Corrosion-Resistant Housing: Constructed from electropolished stainless steel and reinforced polymer composites, the enclosure resists degradation from common laboratory solvents (e.g., acetone, ethanol, diluted acids/bases), ensuring long-term dimensional stability and calibration retention.
• Intelligent LevelControl & AutoCal: Integrated high-sensitivity inclinometer triggers real-time leveling alerts; internal motorized calibration weights initiate automatic adjustment at user-defined intervals or temperature thresholds (±1.5 °C), maintaining metrological traceability without external intervention.
• Ergonomic User Interface: 7-inch full-color touchscreen with customizable workflows, multi-language support, and tactile feedback—designed for gloved operation and compliance with ISO 9241-210 human-centered design principles.

Sample Compatibility & Compliance

The XSR105 accommodates a wide range of sample formats—from powder aliquots and liquid-filled vials to irregularly shaped components—within its 210 mm × 210 mm pan area. Its robust mechanical damping and adaptive filtering algorithms mitigate disturbances caused by static charge, convection currents, or operator proximity. From a regulatory standpoint, the instrument complies with international metrological standards including OIML R 76-1 (2021) and EN 45501:2015. When configured with LabX software and appropriate user access controls, it satisfies data integrity requirements outlined in FDA 21 CFR Part 11, EU Annex 11, and WHO TRS 996, supporting electronic signatures, audit trails, and role-based permissions essential for GLP and GMP audits.

Software & Data Management

The XSR105 natively integrates with METTLER TOLEDO’s LabX laboratory software platform. LabX provides centralized method management, automated report generation (PDF/CSV), and secure database storage compliant with ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available). All weighing events—including calibration logs, user logins, parameter changes, and result exports—are timestamped and digitally signed. Optional barcode scanning enables sample ID linkage, eliminating manual transcription errors and enabling full chain-of-custody documentation for QA/QC workflows.

Applications

• Raw material receipt inspection in pharmaceutical and chemical manufacturing
• Formulation batch preparation and intermediate checks in API synthesis
• Reference standard weighing in analytical method validation (per ICH Q2(R2))
• Stability study sample preparation under controlled environment rooms
• In-process quality control on production lines where rapid turnaround is critical
• Teaching laboratories requiring durable, intuitive instrumentation for metrology fundamentals

FAQ

Does the XSR105 require daily calibration?
No—AutoCal functionality enables automatic recalibration triggered by temperature deviation or scheduled intervals; however, daily verification using certified test weights is recommended per ISO/IEC 17025 and internal SOPs.
Can the SmartPan™ be sterilized in an autoclave?
The SmartPan™ assembly is not autoclavable; it is designed for wipe-down decontamination using compatible disinfectants per manufacturer guidelines.
Is the XSR105 suitable for use in ISO Class 5 cleanrooms?
Yes—its sealed housing, absence of ventilation grilles, and low particle-shedding materials meet ISO 14644-1 requirements when operated within specified environmental parameters.
What connectivity options are available for data export?
Standard Ethernet (TCP/IP), RS232, and USB host/device ports support direct integration with LIMS, ERP, or MES systems without middleware.
How does the XSR105 handle electrostatic interference during powder weighing?
It incorporates active electrostatic compensation via built-in ionizer detection logic and adaptive filtering—reducing drift in low-humidity environments without requiring external ionizing equipment.