PerkinElmer NexION 300Q ICP-MS System (Refurbished)

Overview

The PerkinElmer NexION 300Q is a high-performance, triple-quadrupole inductively coupled plasma mass spectrometer engineered for ultra-trace elemental analysis in demanding regulatory and research environments. Unlike conventional single-quadrupole ICP-MS platforms, the NexION 300Q employs a true three-stage mass filtering architecture: Q1 functions as an ion transmission lens with intrinsic resistance to contamination; Q2 houses the patented Universal Cell Technology™ (UCT), enabling simultaneous use of helium (collision mode), hydrogen, oxygen, or ammonia (reaction modes) without hardware reconfiguration; and Q3 delivers unit-mass resolution with <0.75 amu peak width at 10% height. This architecture eliminates the need for manual mode switching, reduces polyatomic interferences (e.g., ⁴⁰Ar³⁵Cl⁺ on ⁷⁵As⁺, ⁴⁰Ar⁴⁰Ar⁺ on ⁸⁰Se⁺), and supports stable, long-duration analyses—critical for multi-element environmental monitoring (EPA Method 200.8), clinical trace metal quantification (CLIA-compliant workflows), and semiconductor-grade material certification (SEMI F57).

Key Features

• Triple-cone interface: Reduces pressure differentials across vacuum stages, minimizing ion beam divergence and reducing cone clogging frequency by >60% versus dual-cone systems.
• Universal Cell Technology™ (UCT): Enables real-time selection of collision/reaction gases without mechanical valve actuation or dwell-time penalties—validated for >95% removal of oxide-based interferences (CeO⁺/Ce⁺ < 0.5%) and doubly-charged species (Ba²⁺/Ba⁺ < 1.2%).
• Three-quadrupole mass separation: Q1 separates ions from neutral species pre-cell; Q2 performs interference mitigation; Q3 provides final mass-resolved detection—ensuring unambiguous isotope identification and quantitative reproducibility (RSD < 2.5% over 8-hour runs).
• Integrated Syngistix software: Supports automated method development, isotope ratio calculations (e.g., ²⁰⁶Pb/²⁰⁷Pb geochronology), and audit-trail-enabled data handling compliant with FDA 21 CFR Part 11 and GLP/GMP requirements.
• Refurbishment standard: Includes full replacement of consumables (torch, sampler/skimmer cones, pump oils), calibration with NIST-traceable multi-element standards (Inorganic Ventures ICV-4), and verification against ASTM D5673 detection limit criteria.

Sample Compatibility & Compliance

The NexION 300Q accepts liquid samples via standard nebulization (glass concentric, microflow, or desolvating systems) and solid samples via laser ablation (with optional CETAC LSX-213). It meets ISO/IEC 17025:2017 requirements for testing laboratories when operated within validated methods. All refurbished units undergo comprehensive compliance verification—including background equivalent concentration (BEC) assessment, mass calibration stability (±0.02 amu over 24 h), and detector linearity validation (R² ≥ 0.9999 across 8 orders of magnitude). The system is routinely deployed in laboratories adhering to EPA 6020B, USP <232>/<233>, and ISO 17294-2 protocols.

Software & Data Management

Syngistix for ICP-MS v3.5+ provides intuitive workflow-driven acquisition, real-time interference correction mapping, and customizable reporting templates. Raw data files (.raw) are stored in vendor-neutral formats compatible with third-party statistical packages (e.g., R, Python pandas). Audit trails record all user actions—including method edits, calibration events, and result approvals—with timestamped digital signatures. Optional 21 CFR Part 11 modules enable electronic signature enforcement, role-based access control, and immutable archive generation for regulated QC/QA environments.

Applications

• Environmental: Quantification of As, Cd, Pb, U, and Pu isotopes in drinking water (EPA 200.8), soil leachates (TCLP), and airborne particulates (NIOSH 7300).
• Clinical & Pharma: Monitoring Pt-based chemotherapeutics in serum, Gd retention in MRI contrast agents, and elemental impurities in APIs per ICH Q3D.
• Geochemical: High-precision isotope ratio analysis (e.g., Sr, Nd, Hf) for provenance studies using MC-ICP-MS–compatible sample introduction.
• Materials Science: Trace contaminant profiling (<10 ppt) in high-purity silicon wafers, battery cathode precursors, and catalyst formulations.

FAQ

What refurbishment level does this NexION 300Q undergo?
Each unit receives full OEM-recommended refurbishment: replacement of RF torch, sampler/skimmer cones, vacuum pump oils, detector components, and complete recalibration using NIST SRM 3100 series standards.
Is original factory documentation included?
Yes—electronic copies of the instrument manual, safety documentation, software license keys, and full refurbishment certification report are provided.
Can this system be upgraded to support hyphenated techniques?
Yes—the NexION 300Q features standard LC-ICP-MS and LA-ICP-MS interfaces; compatibility with Agilent 1290 Infinity II or CETAC ASX-560 is verified prior to shipment.
What is the expected operational lifetime post-refurbishment?
Based on component wear analysis and historical field data, refurbished NexION 300Q systems demonstrate ≥5 years of reliable operation under typical laboratory duty cycles (≤8 hrs/day, 5 days/week).
Do you provide installation and method transfer support?
Yes—remote or on-site commissioning, method validation assistance (including spike recovery, MDL/IDL determination), and operator training are available as optional service packages.