Rainin XLS+ Multi-Channel Pipette

Overview

The Rainin XLS+ Multi-Channel Pipette is a precision-engineered liquid handling platform developed by Rainin—a global leader in pipetting technology and a Mettler Toledo brand—specifically for high-throughput, reproducible multichannel operations in life science, pharmaceutical, clinical diagnostics, and academic research laboratories. Designed around the patented LiteTouch™ LTS (Low-Torque Sealing) system, the XLS+ series eliminates traditional high-force tip attachment and ejection, significantly reducing operator fatigue and repetitive strain injury (RSI) risk during extended use. Its measurement principle relies on air displacement with mechanical or motor-driven piston actuation, calibrated per ISO 8655 and validated against ASTM E2758 standards. The XLS+ family comprises two distinct configurations: the manually operated Pipet-Lite™ XLS+, optimized for tactile sensitivity and intuitive control; and the E4 XLS+ electronic version, integrating programmable workflows, real-time feedback, and traceable operation logs essential for regulated environments.

Key Features

• LiteTouch™ LTS system ensures consistent, low-torque tip sealing across all channels—reducing required force by up to 85% compared to conventional universal-fit pipettes.
• Patented LTS tip architecture features a minimized sealing surface and front-stop design, enabling rapid, channel-to-channel uniform seal formation without over-compression.
• Gradual tip ejection mechanism minimizes lateral stress on pipette shafts and prevents accidental tip drop or misalignment.
• E4 XLS+ model includes a full-color graphical LCD display with rotary menu navigation, ergonomic thumb lever, and dual-finger grip contouring for prolonged use comfort.
• Programmable fluid handling modes: standard pipetting, reverse pipetting, continuous dispensing, mixing, serial dilution, titration, and stepwise volume incrementing.
• Independent speed control for aspiration, dispense, and mix steps—critical for handling viscous, volatile, or temperature-sensitive samples (e.g., glycerol solutions, cold PBS, or ethanol-based reagents).
• RFID tag embedded in each unit supports automated calibration history logging, asset management, and audit-ready documentation per FDA 21 CFR Part 11 requirements.
• Rechargeable lithium-ion battery (included) provides >1,000 pipetting cycles per charge; optional rapid-charging station supports simultaneous charging of three E4 units within 60 minutes.

Sample Compatibility & Compliance

The Rainin XLS+ is compatible exclusively with Rainin LTS tips—ensuring dimensional consistency, leak-free performance, and metrological traceability. It supports aqueous, mildly viscous (up to 50% glycerol), and low-volatility liquids across volumes ranging from 0.5 µL to 1,250 µL (model-dependent). All units undergo factory calibration per ISO 8655-2 and are supplied with a Certificate of Conformance. The E4 XLS+ meets GLP/GMP operational prerequisites through built-in audit trails, user-accessible service logs, password-protected method editing, and time-stamped event recording. It complies with IEC 61326-1 (EMC), IEC 61010-1 (safety), and supports integration into LIMS or ELN systems via USB or optional Bluetooth module.

Software & Data Management

The E4 XLS+ operates on an embedded firmware platform supporting method storage (up to 99 protocols), user-defined volume presets, and customizable start-up screens. Calibration data—including date, technician ID, gravimetric results, and environmental conditions—is stored locally and retrievable via the display or exported as CSV files. RFID tagging enables seamless linkage between physical hardware and digital calibration records in enterprise asset management systems. Firmware updates are delivered via secure USB transfer, maintaining version control integrity. No cloud dependency or proprietary software installation is required—ensuring data sovereignty and regulatory compliance in controlled environments.

Applications

The XLS+ excels in applications demanding inter-channel precision and operator endurance: 96- and 384-well plate filling for ELISA, qPCR setup, cell culture passaging, compound library normalization, high-content screening, and QC testing in biomanufacturing. Its LTS system proves especially advantageous in cold-room workflows (4 °C) and biosafety cabinets where glove resistance increases manual effort. In regulated labs, the E4’s traceability features support validation protocols under USP , ISO/IEC 17025, and Annex 11 compliance frameworks.

FAQ

Is the XLS+ compatible with non-LTS tips?
No. Only Rainin LTS tips are supported to guarantee metrological accuracy, seal integrity, and warranty validity.
What is the recommended recalibration interval?
Annual calibration is advised for routine use; more frequent verification (e.g., quarterly) is recommended in GxP environments or after impact events.
Can the E4 XLS+ be used in laminar flow hoods without interference?
Yes—the device emits no RF noise that compromises hood performance and features IP54-rated ingress protection against dust and splashes.
Does the manual Pipet-Lite XLS+ include LiteTouch™ as standard?
Yes. LiteTouch™ is integral to all XLS+ variants, including manual models, ensuring uniform tip loading force across channels.
How is traceability maintained during multi-user lab deployments?
Each E4 unit stores user login history, method execution timestamps, and calibration metadata—enabling full forensic reconstruction of pipetting events per ALCOA+ principles.