Sanotac SP6015 Preparative High-Pressure Solvent Delivery Pump
| Brand | Sanotac |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | OEM Manufacturer |
| Model | SP-6015 |
| Flow Rate | 0.01–600.00 mL/min (0.01 mL/min increment) |
| Maximum Pressure | 15 MPa |
| Flow Accuracy | ±1.0% |
| Flow Precision (RSD) | ≤0.5% |
| Pressure Pulsation | ≤0.5 MPa |
| Display | 256×64 dot matrix LCD with adjustable backlight |
| Control Interface | Front-panel keypad + RS-232/USB open communication protocol compliant with ASTM E1384 and FDA 21 CFR Part 11 audit trail requirements |
| Power Supply | 85–264 VAC, 500 W |
Overview
The Sanotac SP6015 Preparative High-Pressure Solvent Delivery Pump is an engineered solution for high-flow, high-pressure liquid chromatography applications requiring precise, stable, and reproducible solvent delivery in preparative-scale purification workflows. Based on dual-piston parallel pumping architecture with floating piston design, the SP6015 operates on positive displacement principles to deliver continuous, pulse-dampened flow across a wide dynamic range—from trace-level analytical support (0.01 mL/min) to full-scale preparative fractionation (600 mL/min). Its pressure capability of up to 15 MPa (2175 psi) enables compatibility with sub-2 µm particle-packed columns and high-viscosity mobile phases commonly used in flash chromatography, SMB (simulated moving bed), and process-scale HPLC. The pump integrates real-time chamber pressure feedback and solvent compressibility compensation algorithms, ensuring consistent volumetric output independent of solvent composition or temperature-induced density variation—critical for method transfer between analytical and preparative platforms.
Key Features
- Dual-piston parallel drive system with floating piston seal architecture—reduces mechanical wear and extends seal lifetime beyond 10,000 operating hours under 10 MPa continuous load.
- Microprocessor-controlled flow regulation with 0.01 mL/min resolution and programmable ramping profiles for gradient elution and method scouting.
- Proprietary cam-profile pulsation compensation technology reduces baseline noise to <0.5 MPa pressure ripple, minimizing detector interference in UV/Vis and mass-sensitive detection systems.
- Multi-point flow calibration curves stored in non-volatile memory ensure linearity and accuracy across the full 0.01–600 mL/min range—validated per ISO 5725-2:2019 repeatability protocols.
- Open communication interface (RS-232 & USB) supports bidirectional command exchange with third-party chromatography data systems (CDS), including Empower, Chromeleon, and OpenLab CDS, with full 21 CFR Part 11-compliant audit trail logging.
- Self-luminous 256×64 pixel LCD display with adjustable brightness and uniform viewing-angle color fidelity—designed for glove-compatible operation in controlled environments (ISO Class 5–8 cleanrooms).
Sample Compatibility & Compliance
The SP6015 accommodates a broad spectrum of solvents—including acetonitrile, methanol, THF, DMSO, and aqueous buffers—via its 316L stainless steel pump head and chemically resistant PTFE/Kel-F sealing materials. It meets mechanical safety standards per EN 61010-1:2010 and electromagnetic compatibility requirements per IEC 61326-1:2021. For regulated laboratories, the pump supports GLP/GMP-aligned workflows through user-accessible calibration logs, electronic signature-capable method storage (10 programmable methods), and timestamped event records for pressure limit breaches, flow deviations, or power interruptions.
Software & Data Management
The SP6015 firmware implements a deterministic real-time control loop (10 ms cycle time) synchronized with external trigger inputs from detectors or fraction collectors. All operational parameters—including flow setpoint, pressure limit, gradient slope, and dwell volume compensation—are configurable via front-panel navigation or remote API calls. Data export is supported in CSV format with ISO 8601 timestamps; internal memory retains ≥10,000 event entries with automatic rollover. When integrated into networked CDS environments, the pump complies with ASTM E1384-16 (Standard Guide for Computerized Analytical Instrument Systems) for secure data integrity and version-controlled method archiving.
Applications
- Preparative HPLC purification of pharmaceutical intermediates, natural products, and synthetic peptides.
- Flash chromatography systems for rapid compound isolation at gram-to-kilogram scale.
- Simulated moving bed (SMB) and multi-column continuous chromatography (MCCC) process development.
- Method translation from UHPLC analytical methods to scalable preparative conditions.
- Automated solvent delivery in parallel reaction screening and high-throughput synthesis platforms.
FAQ
What is the maximum recommended operating pressure for continuous use?
The SP6015 is rated for continuous operation up to 12 MPa; 15 MPa is specified as short-term burst pressure (≤5 min duration) per ISO 15848-1 leak-tightness validation.
Does the pump support gradient mixing internally?
No—the SP6015 is a single-channel high-pressure pump; gradient formation requires external low-pressure mixing modules or dual-pump configurations with synchronized timing control.
Is flow calibration traceable to NIST standards?
Yes—factory calibration uses gravimetric reference standards certified to NIST SRM 2809 (water density at 20 °C) and verified against ISO 4064-2:2014 volumetric flowmeter protocols.
Can the pump be integrated into a GMP-compliant manufacturing environment?
Yes—when deployed with validated CDS software, electronic signatures, and change-controlled firmware updates, the SP6015 satisfies Annex 11 and PIC/S PI 011-3 requirements for automated equipment in pharmaceutical production.
What maintenance intervals are recommended for the floating piston seals?
Under typical organic solvent usage at ≤10 MPa, seal replacement is recommended every 18 months or after 6,000 hours of cumulative runtime—documented via built-in service counter and logged in audit trail history.
