Sartorius Arium® Comfort II Integrated Pure & Ultrapure Water System

Overview

The Sartorius Arium® Comfort II is an integrated, benchtop-ready pure and ultrapure water system engineered for laboratories requiring simultaneous, on-demand access to both ASTM Type II pure water and ASTM Type I ultrapure water. It employs a multi-stage purification architecture anchored by continuous electrodeionization (EDI), dual-stage activated carbon and ion exchange filtration, and optional dual-wavelength (185/254 nm) UV irradiation—designed to suppress microbial proliferation and photolyze residual organic compounds. Unlike conventional systems that rely on static storage tanks vulnerable to atmospheric recontamination, the Arium® Comfort II delivers ultrapure water directly into a sterile, single-use Arium® bag tank—eliminating headspace exposure, minimizing leachables, and ensuring consistent feedwater quality for sensitive analytical and life science applications. Its modular mechanical design supports flexible installation modes—including countertop, wall-mounted, or under-bench configurations—without compromising structural integrity or service accessibility.

Key Features

• Simultaneous production of ASTM Type II (pure) and Type I (ultrapure) water from a single integrated platform
• Electrodeionization (EDI) core technology enabling continuous deionization without chemical regeneration or downtime
• Proprietary dual-stage filtration: pre-filter + high-capacity mixed-bed ion exchange resin with optimized kinetics for low-resistivity breakthrough delay
• Optional integrated 185/254 nm UV lamp assembly for real-time TOC reduction and microbiological control
• Sealed, disposable Arium® bag tank (available in multiple volumes) preventing ambient particulate ingress, CO₂ absorption, and biofilm formation
• Touchscreen HMI with glove-compatible interface, intuitive icon-based navigation, and multilingual support (English, German, French, Spanish, Chinese)
• iJust intelligent water management software providing dynamic flow optimization, predictive maintenance scheduling, and real-time resource usage analytics
• Comprehensive onboard sensors monitoring resistivity, TOC (with optional integrated TOC monitor), temperature, pressure, and UV intensity

Sample Compatibility & Compliance

The Arium® Comfort II is validated for use across regulated and non-regulated laboratory environments. Its output meets or exceeds specifications defined in ASTM D1193 (Type I and Type II), ISO 3696 (Grade 1 and Grade 2), and CLSI EP21-A for clinical laboratory water. The system’s architecture supports audit-ready documentation workflows: iJust software logs all operational parameters—including timestamped resistivity/TOC values, UV lamp runtime, filter saturation status, and bag tank exchange events—in tamper-evident format compliant with FDA 21 CFR Part 11 requirements when deployed with appropriate IT infrastructure. All wetted materials conform to USP Class VI biocompatibility standards; no stainless-steel contact surfaces are used in the final polishing loop, eliminating metallic leaching risks critical for ICP-MS, LC-MS, and cell culture applications.

Software & Data Management

iJust software serves as the embedded intelligence layer for the Arium® Comfort II. It continuously analyzes water quality trends and system load patterns to dynamically adjust pump speed, EDI current density, and UV exposure duration—maximizing water yield while maintaining strict purity thresholds. The software calculates optimal cartridge replacement intervals based on actual usage metrics—not fixed calendar schedules—reducing consumable waste and extending downstream component life. All sensor data, alarm histories, and user actions are stored locally with export capability via USB or Ethernet (Modbus TCP). Optional cloud connectivity enables remote system health monitoring, predictive diagnostics, and centralized fleet management across multi-site laboratory networks—all without compromising data sovereignty or network security protocols.

Applications

The Arium® Comfort II supplies high-fidelity water for demanding analytical and biological workflows including but not limited to: HPLC mobile phase preparation and column equilibration; ICP-MS and GF-AAS trace metal analysis; ion chromatography eluent generation; spectrophotometric assay calibration; ELISA and RIA reagent formulation; mammalian cell culture media and buffer preparation; molecular biology applications such as PCR, qPCR, and next-generation sequencing library construction; histology staining solutions; and as feedwater for autoclaves, glassware washers, humidifiers, and water baths. Its consistently sub-2 ppb TOC and <0.001 EU/mL endotoxin levels make it suitable for pharmacopeial-compliant pharmaceutical QC testing and biomanufacturing process development.

FAQ

Does the Arium® Comfort II require periodic validation per ISO/IEC 17025?
Yes—while the system is factory-qualified, laboratories must perform initial and periodic performance qualification (PQ) using documented protocols aligned with ISO/IEC 17025 and internal SOPs. Sartorius provides IQ/OQ/PQ templates and certified reference standards for resistivity, TOC, and endotoxin verification.
Can the integrated TOC monitor be calibrated in-house?
Yes—the optional TOC sensor supports two-point calibration using NIST-traceable potassium hydrogen phthalate (KHP) and sucrose standards, with full calibration history logged and exportable.
What is the expected service life of the EDI module under typical lab usage?
With proper pretreatment and adherence to iJust-recommended maintenance intervals, the EDI stack maintains stable performance for ≥3 years or 15,000 operating hours—validated through accelerated lifetime testing per IEC 60751.
Is the Arium® bag tank compatible with sterile filtration integration?
Yes—each bag is pre-sterilized via gamma irradiation and features a 0.22 µm hydrophilic PES membrane vent filter, enabling direct connection to point-of-use sterile dispensing modules without additional filtration steps.