Sartorius CPA324S Analytical Balance

Overview

The Sartorius CPA324S Analytical Balance is a precision laboratory instrument engineered for high-accuracy mass determination in regulated and research-intensive environments. Utilizing electromagnetic force compensation (EMFC) technology with a patented monolithic sensor architecture, the CPA324S delivers exceptional stability, minimal drift, and long-term reproducibility under variable thermal and mechanical conditions. With a readability of 0.1 mg and a capacity of 320 g, it meets the stringent requirements of analytical chemistry, pharmaceutical quality control, materials science, and academic research laboratories. Its design adheres to fundamental metrological principles defined in OIML R76 and ISO/IEC 17025, ensuring traceable performance across daily operational cycles.

Key Features

• Internal calibration and adjustment via Sartorius isoCAL — fully automated, motor-driven, temperature-compensated calibration using built-in reference masses
• Backlit LCD display with 16 mm high digits for rapid, unambiguous reading under diverse ambient lighting conditions
• Large, easily accessible draft shield with optimized airflow dynamics and smooth, non-porous surfaces for efficient cleaning and contamination control
• Robust monolithic EMFC sensor providing superior resistance to overload, shock, and thermal transients
• RS-232C serial interface supporting bidirectional communication with PCs, LIMS, or Sartorius YDP03-0CE printers for audit-compliant data export
• Built-in application functions including percentage weighing, net/gross accumulation, animal (dynamic) weighing, unit conversion (g, oz, ct, etc.), and piece counting — all accessible without external software

Sample Compatibility & Compliance

The CPA324S accommodates standard laboratory sample containers, crucibles, and weighing boats on its Ø 80 mm stainless-steel pan. Its draft shield geometry supports both volatile and hygroscopic samples while minimizing convective interference. The balance is compliant with Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) documentation requirements: all calibrations, weighings, and user actions can be timestamped and logged when connected to compatible printers or data acquisition systems. It supports 21 CFR Part 11–ready configurations when integrated with validated Sartorius LabX software (optional), enabling electronic signatures, audit trails, and role-based access control. Conformance to ISO 9001, ISO/IEC 17025, and ASTM E898-20 is inherent in its design, verification, and factory calibration protocols.

Software & Data Management

While the CPA324S operates autonomously via its intuitive front-panel interface, its RS-232C port enables seamless integration into digital lab ecosystems. Raw weighing data — including date/time stamps, operator ID (if entered), gross/net/tare values, and calibration status — can be transmitted in ASCII format for direct import into Excel, LIMS, or ELN platforms. When paired with Sartorius LabX software (sold separately), the device supports full electronic record management: automatic report generation, statistical process control (SPC) charting, deviation alerts, and secure archiving aligned with FDA 21 CFR Part 11 and EU Annex 11 expectations. All internal memory operations retain integrity during power loss due to non-volatile storage architecture.

Applications

The CPA324S serves as a foundational measurement tool across multiple disciplines: quantitative preparation of reference standards and titrant solutions in pharmaceutical QC; gravimetric analysis of catalysts and nanomaterials in R&D labs; moisture content determination via loss-on-drying protocols; formulation of active pharmaceutical ingredients (APIs) under ICH Q5 and Q7 guidelines; and calibration of secondary standards in metrology labs. Its repeatability (≤ ±0.2 mg) and linearity (≤ ±0.3 mg) ensure consistent performance across multi-shift operations, making it suitable for routine release testing where regulatory scrutiny demands documented accuracy and procedural transparency.

FAQ

Does the CPA324S support external calibration with traceable weights?
Yes — although equipped with internal isoCAL, the balance accepts optional external calibration using Class E2 or better certified weights via the dedicated calibration mode.
Is the RS-232C interface compatible with modern Windows/macOS systems?
Yes — using a USB-to-RS-232 adapter and standard terminal emulation (e.g., Tera Term), data capture is fully functional; LabX provides native driver support.
Can the CPA324S be used in environments with air turbulence or temperature fluctuations?
Its monolithic sensor and isoCAL’s real-time temperature monitoring significantly mitigate environmental influence; however, optimal performance requires placement on a vibration-isolated bench within ±2 °C/h ambient stability.
What documentation is provided for IQ/OQ validation?
Sartorius supplies a comprehensive validation kit including test protocols, acceptance criteria, and blank forms compliant with GAMP5 and ASTM E2500-13 for installation and operational qualification.
Is the backlight adjustable or auto-sensing?
The backlight is manually enabled/disabled via menu setting; no ambient light sensor is included — consistent illumination ensures readability regardless of lab lighting conditions.