SCIEX ExionLC AC Used Liquid Chromatography System

Overview

The SCIEX ExionLC AC is a high-performance, modular liquid chromatography (LC) system engineered for robustness, reproducibility, and seamless integration with mass spectrometry platforms—particularly SCIEX Triple Quad™ and QTRAP® systems. As a second-hand, professionally refurbished unit, this ExionLC AC system retains full functional integrity and meets original manufacturer specifications for flow accuracy (±0.1% RSD), gradient precision (±0.15% RSD), and injection repeatability (≤0.25% RSD). Its core architecture employs low-dispersion binary solvent delivery, active pre-heating of mobile phase lines, and temperature-stabilized column compartment control—enabling consistent retention time stability (<0.02 min RSD over 24 h) under routine analytical conditions. Designed for laboratories requiring regulatory-compliant operation without capital-intensive investment, this unit serves as a validated entry point into LC-based workflows aligned with ASTM D8073, ISO 17025, and USP method requirements.

Key Features

• Modular AC-series architecture: Independent, field-replaceable modules (pump, autosampler, column oven, degasser, controller) ensure minimal downtime and simplified maintenance.
• AC Autosampler with 120-position tray capacity and needle-wash station—supports both partial-loop and full-loop injection modes with programmable wash cycles to minimize carryover (<0.005%).
• AC Binary Pump delivering flow rates from 0.001 to 2.000 mL/min at pressures up to 1300 bar, with real-time pressure monitoring and automatic leak detection.
• AC Column Oven maintaining temperature control from 5 °C to 85 °C (±0.15 °C stability), featuring dual-zone air circulation and pre-heated transfer lines to eliminate thermal band broadening.
• Integrated AC Controller with embedded Ethernet interface (10/100BASE-T) and native support for SCIEX OS and Analyst® software via USB or LAN.
• Pre-installed and licensed Analyst® 1.7.2 software on dedicated Windows 10 Pro workstation—configured for instrument control, sequence management, peak integration, and report generation.

Sample Compatibility & Compliance

The ExionLC AC accommodates standard 2.1–4.6 mm ID analytical columns (up to 250 mm length) and supports reversed-phase, HILIC, ion-exchange, and size-exclusion chromatography methods. It is routinely deployed in regulated environments requiring audit-ready documentation: the system supports 21 CFR Part 11-compliant user authentication, electronic signatures, and full audit trail logging when operated with Analyst® software in secure mode. All refurbished units undergo full functional verification per SpectraLab Scientific’s internal QC protocol—including baseline noise assessment (<±0.5 mAU), dwell volume calibration (≤500 µL), and gradient delay time validation—ensuring conformance with ISO/IEC 17025 clause 6.4.2 for equipment suitability.

Software & Data Management

Control and data acquisition are managed through SCIEX Analyst® software (v1.7.2 or later), which provides method editor, real-time chromatogram display, automated peak detection, and customizable reporting templates compliant with GLP and GMP documentation standards. Raw data files (.wiff) are stored in a hierarchical project structure with timestamped metadata, supporting retrospective reprocessing and version-controlled method archiving. The included workstation features SSD storage, 16 GB RAM, and dual-monitor support—optimized for concurrent instrument monitoring and multi-channel data review. Remote access capabilities (via secure VPN) allow off-site troubleshooting and method transfer validation without physical presence.

Applications

This refurbished ExionLC AC system is routinely applied in food safety labs for pesticide residue quantitation (AOAC 2007.01), environmental testing for PFAS and pharmaceuticals in wastewater (EPA Method 1694), clinical research for therapeutic drug monitoring (TDM) of immunosuppressants, and forensic toxicology screening for opioids and stimulants. Its low dead-volume flow path and precise gradient formation make it especially suitable for UHPLC-compatible methods requiring sub-2 µm particles and elevated backpressures. Laboratories performing method transfer from legacy Agilent 1290 or Waters Acquity systems will find the ExionLC AC’s retention time predictability and peak shape fidelity highly compatible.

FAQ

Is this ExionLC AC system fully tested prior to shipment?
Yes—each unit undergoes comprehensive performance verification including pump linearity, autosampler precision, column oven temperature uniformity, and system pressure integrity. A signed Certificate of Verification is provided with shipment.
Does the 6-month warranty cover parts and labor?
Yes—the warranty includes all components, consumables installed at time of dispatch (e.g., frits, seals), and on-site or remote technical support for hardware- and software-related issues.
Can this system be integrated with non-SCIEX mass spectrometers?
Yes—the ExionLC AC features standard analog and digital I/O ports (TTL, RS-232, Ethernet) and supports third-party MS triggering via external start/stop signals; API interface documentation is available upon request.
Are original manufacturer service records available?
Where accessible, historical service logs and firmware revision history are supplied; all units have been updated to the latest stable firmware version compatible with Analyst® 1.7.2.
What documentation accompanies the system?
Users receive the original SCIEX ExionLC AC Hardware Manual, Analyst® Software User Guide, SpectraLab Refurbishment Report, Certificate of Verification, and completed Installation Qualification (IQ) checklist.