SSI ReaXus Series Constant Flow Precision Reciprocating Piston Pumps

Overview

The SSI ReaXus Series represents a family of high-precision, positive displacement reciprocating piston pumps engineered for demanding laboratory and process-scale fluid delivery applications. Operating on the principle of volumetric displacement via precision-machined stainless steel or inert alloy pistons driven by eccentric cam or servo-controlled mechanisms, the ReaXus platform delivers exceptional flow stability, pressure resilience, and long-term reproducibility—critical attributes in analytical and preparative chromatography, flow chemistry, and high-pressure process monitoring. Unlike peristaltic or diaphragm-based alternatives, ReaXus pumps eliminate elastomer degradation and compressibility-related inaccuracies, ensuring traceable, pulse-minimized output across wide dynamic ranges. Each configuration—single- or dual-piston—is optimized for specific operational envelopes: from low-flow, high-accuracy metering (e.g., post-column derivatization reagent delivery) to high-flow, high-pressure purification (e.g., preparative LC or continuous manufacturing feed streams).

Key Features

• Zero-calibration architecture: Factory-trimmed piston geometry and closed-loop pressure feedback (CP models) ensure consistent volumetric accuracy without routine recalibration.
• Ultra-low pulsation performance: Patented low-dead-volume pulse dampeners—combined with dual-piston phasing (LD, CP, PR, HF models)—reduce flow ripple to <±0.2% RSD under typical operating conditions.
• Chemically inert fluid paths: Standard configurations feature 316 stainless steel wetted surfaces; optional PEEK and Hastelloy C-276 components accommodate aggressive solvents (e.g., TFA, HF, anhydrous acids) and biological matrices.
• Thermally stabilized operation: Jacketed pump heads (available on LD, CP, PR, and HF models) enable precise temperature control (±0.5°C) for viscosity-sensitive applications such as polymer solution delivery or cold-chain sample handling.
• Integrated system intelligence: All models support real-time pressure monitoring, automatic piston wash cycles, and programmable ramp profiles (flow/pressure vs. time), with native compatibility for LabVIEW, Empower, and OpenLab CDS via RS-232 or USB virtual COM port.

Sample Compatibility & Compliance

The ReaXus Series accommodates a broad spectrum of sample types—including aqueous buffers, organic solvents (acetonitrile, THF, DCM), corrosive reagents (HCl, HNO₃), and viscous biomolecular solutions (e.g., >50 cP monoclonal antibody formulations). Its inert fluid path options meet ASTM F2081–22 requirements for metallic implant material compatibility testing and ISO 13485-compliant device manufacturing environments. For regulated laboratories, the platform supports audit-trail-enabled operation when paired with 21 CFR Part 11–compliant data acquisition software. Pressure and flow metadata are timestamped, user-identified, and non-erasable—fulfilling GLP documentation standards for method validation (ICH Q2(R2)) and QC release testing.

Software & Data Management

ReaXus pumps operate natively via embedded firmware with local keypad control, while full remote orchestration is enabled through SSI’s ReaXus Control Suite—a Windows-based application supporting multi-pump synchronization, method storage (up to 100 protocols), and export of CSV-formatted logs with millisecond-resolution timestamps. The suite integrates seamlessly with third-party LIMS and ELN platforms via OPC UA or TCP/IP socket communication. All firmware versions undergo annual cybersecurity assessment per NIST SP 800-53 Rev. 5 controls, including secure boot verification and encrypted parameter updates.

Applications

• High-performance liquid chromatography (HPLC/UHPLC): Precise gradient formation, column equilibration, and mobile phase delivery at pressures up to 25,000 psi (CP series).
• LC-MS interface pumping: Low-pulse delivery ensures stable electrospray ionization and reduced source contamination.
• Preparative and process-scale purification: PR and HF models support 300 mL/min throughput at ≥1,000 psi for rapid protein capture or small-molecule isolation.
• Flow chemistry reactors: Constant mass flow under variable backpressure enables stoichiometric control in microreactor and tubular reactor systems.
• Fuel and lubricant analysis: High-pressure diesel injection simulation and oxidative stability testing per ASTM D2272 and ISO 12156-1.
• In-line process monitoring: Integration with PAT tools (e.g., inline UV/VIS, Raman) for real-time concentration tracking in continuous manufacturing suites.

FAQ

What distinguishes the CP series from the LD series?
The CP series incorporates a closed-loop pressure feedback system that dynamically adjusts flow rate to maintain a user-defined setpoint pressure—ideal for variable-resistance applications such as packed-bed reactors. The LD series prioritizes ultra-low pulsation via mechanical dual-piston phasing but operates in open-loop flow mode.
Can ReaXus pumps be used with abrasive slurries?
No—ReaXus pumps are designed for homogeneous liquids only. Suspended solids >1 µm may accelerate seal wear and compromise volumetric accuracy. For slurry handling, consult SSI’s complementary peristaltic or diaphragm pump offerings.
Is firmware update capability available over the network?
Yes—firmware updates are delivered via signed .bin files through USB or RS-232; network deployment requires intermediate host PC coordination per IEC 62443-3-3 segmentation guidelines.
What is the recommended maintenance interval for piston seals?
Under continuous operation at ≤80% of maximum rated pressure, stainless-steel/PEEK configurations require seal inspection every 6,000 hours; Hastelloy-wetted variants extend this to 10,000 hours. SSI provides documented preventive maintenance kits with calibrated torque specifications.
Do ReaXus pumps comply with ATEX or IECEx directives for hazardous areas?
Standard models are not certified for Zone 1/21 use. Explosion-proof variants (marked Ex d IIB T4 Gb) are available upon special order with modified motor housings and intrinsically safe control interfaces.