Sunny Hengping LC1620APlus High-Performance Liquid Chromatograph

Overview

The Sunny Hengping LC1620APlus is a modular, high-reliability high-performance liquid chromatograph engineered for routine and method-development applications in pharmaceutical QC, environmental testing, food safety laboratories, and academic research. Built upon classical reciprocating parallel-piston pump architecture, the system delivers precise, pulse-free solvent delivery across its full flow range (0.000–10.000 mL/min) at pressures up to 42 MPa—enabling compatibility with both standard 3–5 µm particle-packed columns and select sub-2 µm UHPLC-compatible columns under controlled conditions. The UV-Vis detector employs a fully digital signal exchange architecture to minimize analog noise coupling and baseline drift, while its dual-conical flow cell design enhances optical path efficiency and improves signal-to-noise ratio by optimizing light transmission and reducing scattering artifacts. A long-life deuterium lamp ensures stable spectral output across the 190–680 nm range, supporting detection of aromatic compounds, conjugated systems, and many pharmacopoeial analytes without lamp replacement during extended validation runs.

Key Features

• Modular configuration options: Isocratic, binary high-pressure gradient, quaternary low-pressure gradient, and GPC/SEC-ready configurations
• High-precision dual-piston constant-flow pump with integrated one-piece check valve assembly—reducing dead volume and improving seal longevity
• Automatic plunger retraction mechanism for rapid, tool-free seal ring replacement—minimizing downtime during preventive maintenance
• UV-Vis detector with real-time digital signal processing, eliminating analog-to-digital conversion bottlenecks and enhancing data fidelity
• Optimized flow cell geometry featuring parallel dual conical windows—increasing photon collection efficiency and reducing refractive index-induced noise
• Comprehensive detector expandability: compatible with optional PDA, fluorescence (LIF), RI, ELSD, and electrochemical detectors via standardized electrical and fluidic interfaces

Sample Compatibility & Compliance

The LC1620APlus supports a broad spectrum of sample matrices—including small-molecule APIs, residual solvents, pesticide residues, organic acids, amino acids, nucleotides, and synthetic polymers—when paired with appropriate column chemistries (C18, phenyl-hexyl, HILIC, SEC, etc.). Its pressure and flow specifications align with ASTM D7097 (hydrocarbon analysis), ISO 11843-7 (detection limit validation), and USP chromatography guidelines. The system architecture supports audit-trail-capable software environments compliant with FDA 21 CFR Part 11 when operated with validated third-party CDS platforms (e.g., Chromeleon, OpenLab CDS). All wetted components meet ISO 8573-1 Class 3 purity standards for solvent handling, and pump head materials are chemically resistant to common HPLC mobile phases including 0.1% TFA, 10 mM ammonium acetate, and acetonitrile/water gradients.

Software & Data Management

The LC1620APlus operates via RS-232 or USB interface with industry-standard chromatography data systems (CDS), enabling seamless integration into GLP/GMP workflows. It supports full method transfer, sequence definition, peak integration per ICH Q2(R2) principles, and automated calibration curve generation. Raw data files adhere to ANDI/NetCDF format standards for cross-platform interoperability. When deployed with validated CDS solutions, the system provides electronic signatures, user access control tiers, change history logging, and secure archive export—meeting requirements for regulated environments requiring traceability and data integrity per ALCOA+ principles.

Applications

• Pharmaceutical quality control: assay, related substances, dissolution testing per USP/EP monographs
• Environmental analysis: PAHs, PCBs, phenolic pollutants in water and soil extracts
• Food & beverage: preservatives (sorbates, benzoates), sweeteners (aspartame, sucralose), mycotoxins (aflatoxin B1)
• Academic research: natural product isolation tracking, polymer molecular weight distribution (via SEC mode)
• Clinical chemistry: vitamin D metabolites, catecholamines, therapeutic drug monitoring (TDM) panels

FAQ

Is the LC1620APlus compatible with UHPLC columns?

Yes—when operated below 42 MPa and with appropriate dwell volume compensation, it supports 2.1 mm ID columns packed with sub-2 µm particles for higher resolution separations.
What detector options are factory-integrated?

The base configuration includes a variable-wavelength UV-Vis detector; PDA, LIF, RI, ELSD, and electrochemical detectors are available as plug-and-play modules with mechanical and electrical alignment guides.
Does the system support GLP-compliant audit trails?

Native firmware does not include embedded audit trail functionality; however, full compliance is achieved when interfaced with validated third-party CDS software meeting 21 CFR Part 11 requirements.
What maintenance intervals are recommended for the high-pressure pump?

Seal rings should be inspected every 500 hours of operation or after 2000 injections; the automatic plunger retraction feature allows replacement in under 8 minutes without disassembling the pump head.
Can the LC1620APlus be used for gel permeation chromatography?

Yes—the quaternary low-pressure gradient configuration supports GPC/SEC applications with THF, DMF, or chloroform mobile phases, and is compatible with Agilent PLgel or Waters Styragel columns via standard 1/16″ stainless steel tubing connections.