Thermo Fisher Cimarec i Poly 15 and Cimarec i Advanced Multipoint 6/15 Magnetic Stirrers

Overview

The Thermo Fisher Cimarec i Poly 15 and Cimarec i Advanced Multipoint 6/15 are precision-engineered magnetic stirrers designed for high-throughput, reproducible mixing in regulated laboratory environments. Operating on the principle of rotating magnetic fields generated beneath a non-magnetic work surface, these instruments induce controlled rotational motion in magnetic stir bars immersed in liquid samples. Unlike mechanical overhead stirrers, magnetic systems eliminate shaft seals, contamination risks, and mechanical wear—making them ideal for sterile, sealed, or volatile applications. The Cimarec i series integrates digital temperature control with closed-loop feedback, enabling stable thermal management during extended stirring protocols. Its modular architecture supports both parallel screening (e.g., reaction optimization, solubility profiling, buffer preparation) and sequential multi-step workflows across pharmaceutical QC, materials synthesis, and academic research labs.

Key Features

• Two configurable platforms: Cimarec i Poly 15 (15 fixed positions, max 990 rpm) optimized for standardized small-volume vessels; Cimarec i Advanced Multipoint 6/15 (switchable 6- or 15-position layout, 80–2000 rpm) for flexible scalability.
• Seamless, electropolished stainless steel work surface—chemically inert, autoclavable-compatible, and compliant with ISO 15190:2020 requirements for laboratory equipment surface hygiene.
• Digital LED display with intuitive rotary encoder interface; last-used settings (speed, temperature, timer) auto-saved and recalled upon power-up.
• Gradual acceleration algorithm minimizes vortex formation and splashing, ensuring homogeneous dispersion without sample foaming or emulsion breakdown.
• IP64-rated enclosure (Advanced Multipoint only): dust-tight and protected against water splashes from any direction—enabling safe operation in wet lab zones and routine surface cleaning under running deionized water.
• Energy-efficient motor design with adaptive power regulation—reducing standby consumption by up to 35% versus legacy analog stirrers (per IEC 62301:2011 test conditions).

Sample Compatibility & Compliance

These stirrers accommodate standard borosilicate glassware including 250 mL Erlenmeyer flasks (Poly 15), 1 L conical flasks (Poly 15), and up to 3 L beakers per position (Advanced Multipoint). Compatible with PTFE- or PTFE-coated stir bars (diameters 8–15 mm, lengths 20–60 mm). Temperature control is calibrated traceably to NIST-traceable RTDs and validated per ASTM E2251–22 for thermal uniformity across the plate surface (±0.8 °C at 25 °C). The devices meet IEC 61010-1:2010 safety standards for laboratory electrical equipment and are CE-marked for use in EU GMP environments. Documentation packages include Factory Acceptance Test (FAT) reports and optional IQ/OQ protocols aligned with FDA 21 CFR Part 11 data integrity expectations.

Software & Data Management

While standalone operation requires no software, both models support optional integration via RS-232 or USB-to-serial interface into LIMS or ELN ecosystems. Firmware version 2.3+ enables timestamped audit logs (speed, temp, duration, user ID if paired with networked access control), satisfying GLP/GMP electronic record retention requirements. All parameter changes are logged with immutable timestamps and operator identifiers—fully compliant with Annex 11 and ALCOA+ principles. No cloud connectivity is embedded; data export is local-file only (CSV), preserving data sovereignty.

Applications

• Parallel dissolution testing (USP ) across 6–15 vessels under identical hydrodynamic and thermal conditions.
• High-throughput buffer exchange and dialysis setup in protein purification workflows.
• Controlled crystallization studies requiring precise supersaturation maintenance via constant agitation and temperature ramping.
• Cell culture media preparation where shear-sensitive components demand low-RPM homogenization (≥80 rpm minimum ensures laminar flow regime).
• QC release testing of suspensions, emulsions, and colloidal formulations per Ph. Eur. 2.9.37 guidelines.
• Environmental sample digestion (EPA Method 3050B) under controlled heating/stirring to ensure complete acid-metal interaction.

FAQ

What is the maximum recommended viscosity for reliable operation?
For consistent torque delivery and speed stability, the instruments are rated for aqueous solutions up to 1000 mPa·s at 25 °C. Higher viscosities require verification with application-specific stir bar geometry and vessel aspect ratio.
Can the temperature control function be disabled while retaining stirring?
Yes—temperature regulation is fully decoupled from motor control; users may set T = OFF or maintain ambient mode while operating at any speed within the specified range.
Is calibration certification included with shipment?
Each unit ships with a factory-issued calibration certificate covering speed accuracy (±2 rpm at 500 rpm) and temperature sensor linearity (±0.5 °C across −10 to +40 °C), traceable to national metrology institutes.
How is cleaning validated for GMP environments?
The seamless stainless steel surface and IP64 rating allow for swab-based residue testing per PDA TR29; validation templates for cleaning efficacy (ATP bioluminescence, HPLC residual assay) are available upon request.
Are replacement stir plates available as spare parts?
Yes—interchangeable ceramic-coated aluminum and PTFE-coated stainless steel plates are offered (P/Ns: CIMA-PLATE-CERAMIC, CIMA-PLATE-PTFE), each qualified for ≥10,000 cycles under ISO 17025-accredited wear testing.