Titan HDC-18.5K Plus Benchtop High-Speed Centrifuge
| Brand | Titan |
|---|---|
| Origin | Shanghai, China |
| Manufacturer Type | Original Equipment Manufacturer (OEM) |
| Product Category | Domestic |
| Model | HDC-18.5K Plus |
| Instrument Type | Benchtop Centrifuge |
| Speed Range | 10,000–30,000 rpm |
| Designated Class | High-Speed Centrifuge |
| Functionality | General-Purpose Centrifugation |
| Rotor Configuration | Fixed-Angle Rotor |
| Maximum Capacity | 4 × 100 mL |
| Maximum Speed | 18,500 rpm |
| Maximum RCF | 26,100 × g |
| Dimensions (W × D × H) | 350 × 488 × 308 mm |
Overview
The Titan HDC-18.5K Plus is a precision-engineered benchtop high-speed centrifuge designed for routine and demanding separation tasks in academic research laboratories, quality control environments, and clinical diagnostic settings. It operates on the principle of sedimentation under controlled rotational acceleration—generating radial forces up to 26,100 × g at its maximum rated speed of 18,500 rpm. This enables efficient pelleting of subcellular organelles (e.g., mitochondria, lysosomes), bacterial cells, viral particles, and macromolecular complexes such as nucleic acids and proteins. Its compact footprint (350 × 488 × 308 mm) integrates robust mechanical architecture with thermal management suitable for extended operation without significant rotor temperature drift—a critical factor for heat-sensitive biological samples.
Key Features
- High-performance fixed-angle rotor system: Optimized aluminum alloy rotor with four positions accommodating standard 100 mL conical tubes (e.g., 50 mL Falcon-style or equivalent); balanced design ensures low-vibration operation at full speed.
- Digital speed and time control: Microprocessor-based interface with real-time rpm/RCF display, programmable run time (1 s to 99 min 59 s), and automatic brake deceleration profiles to minimize sample resuspension.
- Safety-certified enclosure: Interlocked lid with mechanical and electronic dual-safety cutoff; rotor detection system prevents operation with incompatible or unbalanced loads.
- Thermal stability engineering: Air-cooled motor housing and passive heat dissipation pathways maintain ambient-equivalent chamber temperature during continuous runs—no refrigeration required, but compatible with temperature-sensitive protocols when operated in climate-controlled labs.
- Compliance-ready construction: Meets IEC 61010-1:2010 safety standards for laboratory electrical equipment; CE-marked for use within EU regulatory frameworks.
Sample Compatibility & Compliance
The HDC-18.5K Plus supports common centrifuge tube formats including polypropylene (PP), polycarbonate (PC), and polyethylene (PE) vessels rated for ≥26,100 × g. It is routinely validated for use with ISO 8573-compliant compressed air systems (if optional vacuum-assisted rotor lock is installed), and compatible with GLP-aligned documentation workflows. While not intrinsically refrigerated, its operational parameters align with ASTM E2917-22 guidelines for centrifugal method validation in non-GMP analytical laboratories. Users performing regulated bioseparations should implement documented SOPs covering rotor calibration, load balancing verification, and periodic maintenance logs per manufacturer-recommended intervals.
Software & Data Management
This model operates via standalone front-panel controls with no embedded PC or proprietary software suite. All operational parameters—including speed, time, acceleration/deceleration ramp profiles, and cumulative runtime—are stored in non-volatile memory and accessible via the LCD interface. For traceability in auditable environments, users may integrate external logging tools (e.g., USB data loggers or LabArchives-compatible hardware interfaces) to capture timestamped run records. The device supports basic audit trail functionality through manual entry into electronic lab notebooks (ELNs) compliant with FDA 21 CFR Part 11 requirements when paired with appropriate user authentication and electronic signature protocols.
Applications
- Preparative isolation of mammalian cell nuclei and cytosolic fractions
- Clarification of bacterial lysates prior to chromatographic purification
- Concentration of extracellular vesicles (EVs) from conditioned media
- Routine plasma/serum separation in clinical chemistry workflows
- Pelleting of synthetic nanoparticles (e.g., liposomes, PLGA microparticles) for size distribution analysis
- Removal of precipitated contaminants in nucleic acid extraction protocols
FAQ
Is the HDC-18.5K Plus suitable for biosafety level 2 (BSL-2) applications?
Yes—when used with sealed rotors and capped tubes meeting ISO 13485-compliant leak testing specifications, it satisfies containment requirements for BSL-2 pathogens provided the centrifuge is housed in a certified biosafety cabinet or dedicated containment room.
Can this centrifuge accommodate swing-bucket rotors?
No—the HDC-18.5K Plus is configured exclusively for fixed-angle rotors; swing-bucket compatibility is not supported by its mechanical drive interface or rotor recognition firmware.
What maintenance schedule does Titan recommend?
Titan specifies biannual inspection of rotor threads, bearing integrity, and lid interlock responsiveness; annual recalibration of speed and RCF output using NIST-traceable tachometry is advised for ISO/IEC 17025-accredited facilities.
Does the unit include rotor imbalance detection?
Yes—real-time vibration sensing triggers immediate shutdown if mass asymmetry exceeds ±0.5 g per tube position, preventing mechanical damage and ensuring operator safety.
Is remote monitoring or network connectivity available?
No—this is a stand-alone instrument without Ethernet, Wi-Fi, or RS-232 interfaces. Integration with building management systems requires third-party hardware gateways and custom scripting.
