UXS ADE800 Fully Automated Solid Phase Extraction System
| Brand | UXS |
|---|---|
| Origin | Beijing, China |
| Manufacturer Type | Direct Manufacturer |
| Product Origin | Domestic (China) |
| Model | ADE800 |
| Automation Level | Fully Automatic |
| Channel Configuration | Multi-Channel |
Overview
The UXS ADE800 Fully Automated Solid Phase Extraction System is an integrated laboratory platform engineered for high-throughput, reproducible sample preparation prior to quantitative analysis by HPLC, LC-MS/MS, or ELISA. It implements standardized solid-phase extraction (SPE) methodology—based on selective adsorption, washing, and elution across bonded silica or polymeric sorbent cartridges—to isolate, concentrate, and purify target analytes from complex biological matrices including serum, plasma, milk, infant formula, and fortified food extracts. Designed specifically for routine quantification of fat-soluble vitamins (A, D, E) and functional proteins such as lactoferrin, the ADE800 eliminates manual pipetting, cartridge conditioning, solvent evaporation, and fraction collection steps, reducing analyst exposure to organic solvents and minimizing inter-operator variability. Its architecture complies with core principles of Good Laboratory Practice (GLP) and supports traceable workflow execution required in regulated environments.
Key Features
- Fully automated SPE protocol execution—including cartridge priming, sample loading, wash step sequencing, and targeted elution—with programmable flow rates and pressure monitoring for consistent bed integrity.
- Multi-channel parallel processing capability enables simultaneous handling of up to 8 samples per run, significantly increasing throughput for batched clinical or QC testing.
- Dedicated method templates pre-validated for vitamin A (retinol), vitamin D (25-hydroxyvitamin D₂/D₃), vitamin E (α-tocopherol), and lactoferrin in diverse sample types—reducing method development time and validation burden.
- Integrated solvent management system with sealed reservoirs, low-volume waste collection, and leak detection sensors to ensure operator safety and environmental compliance.
- Modular cartridge holder accommodating standard 1 mL, 3 mL, and 6 mL SPE formats—including reversed-phase (C18), mixed-mode ion exchange (MCX), and hydrophilic-lipophilic balance (HLB) media—without mechanical adaptation.
- Touchscreen HMI with intuitive wizard-driven interface, audit-trail-enabled user authentication, and real-time status visualization of each channel’s progress.
Sample Compatibility & Compliance
The ADE800 accommodates liquid and semi-liquid samples ranging from 0.5 mL to 50 mL volume, including deproteinized serum, acid-hydrolyzed milk digests, and enzymatically treated infant formula suspensions. It maintains compatibility with ISO 17025-accredited laboratories through full support for instrument qualification (IQ/OQ/PQ), electronic signature capability per FDA 21 CFR Part 11, and comprehensive audit trail logging of all method edits, run initiations, and error events. All wetted components are chemically resistant to acetonitrile, methanol, dichloromethane, and aqueous buffers (pH 2–12), ensuring long-term reliability and minimal carryover (<0.05% typical). The system meets CE marking requirements for laboratory equipment (2014/30/EU EMC Directive and 2014/35/EU LVD Directive).
Software & Data Management
Controlled via UXS SPEManager™ v3.2 software, the ADE800 provides method library storage, version-controlled protocol archiving, and automated report generation compliant with ISO/IEC 17025 Clause 7.8. Raw log files include timestamps, pressure profiles, solvent consumption metrics, and channel-specific pass/fail flags for each SPE stage. Export options include CSV, PDF, and XML formats compatible with LIMS integration (via ASTM E1578-compliant API). All data reside locally on the embedded industrial PC; optional network connectivity supports secure remote monitoring and centralized fleet management across multi-site laboratories.
Applications
- Quantitative determination of vitamins A, D, and E in clinical diagnostics, nutritional surveillance programs, and dietary supplement quality control—aligned with AOAC Official Method 2005.05 and USP .
- Isolation and enrichment of lactoferrin from bovine colostrum, human milk, and dairy-based nutraceuticals prior to SDS-PAGE or immunoassay analysis.
- Preparative cleanup of pesticide residues, mycotoxins, and veterinary drug metabolites in food safety testing workflows.
- High-recovery extraction of endogenous steroids and bile acids from urine and saliva for metabolomics profiling.
- Automated sample prep for regulatory submissions requiring documented chain-of-custody and full process traceability (e.g., EFSA dossiers, NMPA registration files).
FAQ
Does the ADE800 support custom SPE method development?
Yes—users can define custom flow rates, dwell times, solvent gradients, and cartridge configurations via the SPEManager™ method editor, with full validation support documentation included.
What maintenance is required for long-term operation?
Routine tasks include monthly calibration verification using certified reference standards, quarterly replacement of pump tubing and check valves, and biannual inspection of manifold seals—all tracked automatically within the maintenance scheduler.
Can the system be integrated into an existing LIMS environment?
Yes—through configurable RESTful API endpoints and scheduled file export to designated network shares, enabling bidirectional sample ID synchronization and result ingestion.
Is training provided for method transfer and troubleshooting?
UXS offers on-site installation qualification, operator certification workshops, and remote technical support with SLA-backed response times for critical issues.
Are consumables such as SPE cartridges and solvents supplied by UXS?
UXS provides validated cartridge kits for vitamin and lactoferrin applications; however, standard analytical-grade solvents and third-party cartridges meeting ISO 8573-1 purity specifications are fully compatible.
