UXS DSPE Fully Automated Large-Volume Solid Phase Extraction System
| Brand | UXS |
|---|---|
| Origin | Beijing, China |
| Manufacturer Type | Direct Manufacturer |
| Product Origin | Domestic (China) |
| Model | DSPE |
| Automation Level | Fully Automatic |
| Number of Channels | 8 Parallel & Independently Controllable Channels |
| Cartridge/Membrane Compatibility | Universal (Column and Disk Formats) |
| Flow Rate Control Range | 0–60 mL/min |
| Solvent Selection Capacity | 9 Independent Solvent Reservoirs |
| Maximum Sample Throughput | >32 Samples per Batch |
| Sample Loading Volume Range | 1–20,000 mL |
| Wetted Materials | PTFE Only |
Overview
The UXS DSPE Fully Automated Large-Volume Solid Phase Extraction System is an engineered solution for high-throughput, method-driven sample preparation in environmental, pharmaceutical, food safety, and clinical laboratories. Built upon a dual-mode fluidic architecture, the system performs solid-phase extraction (SPE) using either traditional packed-bed cartridges or membrane-based disks—enabling consistent recovery of analytes across diverse matrix types and volume scales. Its core operational principle relies on precise pressure- and gravity-assisted flow control, eliminating reliance on peristaltic pumps or solenoid valves in critical solvent pathways. This design ensures minimal carryover, reduced maintenance intervals, and compliance with GLP/GMP-aligned workflows where trace-level reproducibility and method traceability are mandatory.
Key Features
- Eight independently programmable channels support parallel processing without cross-contamination; each channel operates under individual flow, timing, and solvent selection parameters.
- True column-and-disk universality: accommodates standard 1–20 mL SPE cartridges and 47 mm or 90 mm extraction disks without hardware modification.
- PTFE-only wetted path from solvent reservoir to collection tube—ensuring chemical inertness for aggressive eluents (e.g., concentrated acids, bases, chlorinated solvents) and minimizing adsorptive losses of polar or labile compounds.
- Programmable multi-step elution: enables sequential low-volume solvent pulses followed by defined equilibration periods within the sorbent bed—critical for maximizing analyte desorption efficiency in complex biological or environmental matrices.
- Dedicated pre-concentration module with isolated solvent routing allows evaporation of initial eluate fractions prior to reconstitution or secondary concentration steps—eliminating intermediate transfer and associated contamination risk.
- Direct eluate delivery: eluent flows straight from the cartridge/disk outlet into designated collection tubes or inline dehydration columns—bypassing manifolds, switching valves, and transfer tubing that introduce dead volume and memory effects.
Sample Compatibility & Compliance
The DSPE system supports aqueous, semi-aqueous, and organic-rich samples—including wastewater, plasma, urine, milk extracts, and soil leachates—across loading volumes from 1 mL to 20 L. Its open-platform design permits integration with common SPE sorbents (C18, HLB, SCX, SAX, Florisil, silica, and mixed-mode phases) and certified reference materials (CRMs). The instrument meets essential functional requirements for ISO/IEC 17025-accredited laboratories and aligns with ASTM D5088 (SPE for water analysis), USP <2021> (sample preparation for pharmaceutical testing), and EPA Method 500/600 series protocols. Full audit trail logging—including user actions, method version, timestamped step execution, and solvent usage—is retained locally and exportable for FDA 21 CFR Part 11-compliant environments.
Software & Data Management
The embedded UXS SPEControl™ software provides intuitive graphical method building, real-time flow monitoring, and automated validation reporting. Users define multi-solvent gradients, dwell times, vacuum levels (where applicable), and fraction collection logic via drag-and-drop workflow templates. All methods are digitally signed and version-controlled. Raw run logs include pressure profiles, actual vs. target flow rates per channel, solvent consumption per step, and error codes—all stored in SQLite format with SHA-256 checksum integrity verification. Export options include CSV, PDF analytical reports, and XML-compatible method files compatible with LIMS interfaces (via REST API or ODBC drivers).
Applications
- Environmental monitoring: trace analysis of PFAS, pesticides, PAHs, and pharmaceutical residues in surface water, groundwater, and wastewater effluents (EPA 1694, 537.1).
- Clinical toxicology: high-volume plasma/urine cleanup prior to LC-MS/MS quantification of opioids, stimulants, and novel psychoactive substances.
- Food safety: extraction of mycotoxins, veterinary drug residues, and plasticizers from dairy, meat, and cereal matrices per EU Commission Regulation (EC) No 401/2006.
- Pharmaceutical R&D: purification of reaction mixtures and isolation of active metabolites from fermentation broths at pilot scale.
FAQ
Does the DSPE system support method validation according to regulatory guidelines?
Yes—it records full procedural metadata, including operator ID, method revision, environmental conditions (optional sensor input), and real-time performance metrics required for ICH Q2(R2) and ISO/IEC 17025 validation documentation.
Can I use non-UXS branded SPE cartridges or disks?
Yes—the system accepts all standard-format cartridges (1–20 mL) and 47 mm / 90 mm disks from third-party vendors, provided mechanical fit and sealing interface compatibility are verified.
Is remote monitoring or unattended overnight operation supported?
Yes—integrated Ethernet connectivity enables remote status checks, job queue management, and email/SNMP alerts for completion or fault conditions; runs continuously for up to 72 hours without intervention.
How is system cleaning and carryover prevention managed?
Each channel includes dedicated solvent rinse cycles before and after sample loading, plus optional post-run bake-out using heated air purge—validated to achieve <0.01% carryover for high-sensitivity applications.
