Xiangyi CL8R Ultra-High-Capacity Refrigerated Centrifuge
| Brand | Xiangyi |
|---|---|
| Origin | Hunan, China |
| Manufacturer Type | Direct Manufacturer |
| Product Category | Domestic |
| Model | CL8R |
| Instrument Type | Floor-Standing Centrifuge |
| Speed Class | Low-Speed Centrifuge (up to 8,000 rpm) |
| Function | Refrigerated Centrifuge |
| Configuration | Horizontal Rotor Centrifuge |
| Separation Level | Biological Macromolecules |
| Maximum Capacity | 6 × 2400 mL |
| Maximum Speed | 8,000 rpm |
| Maximum RCF | 14,472 × g |
| Dimensions (W×D×H) | 870 × 990 × 1000 mm |
Overview
The Xiangyi CL8R Ultra-High-Capacity Refrigerated Centrifuge is an engineered solution for large-scale, temperature-sensitive separation tasks in biopharmaceutical manufacturing, vaccine production, blood component processing, and industrial biotechnology. Designed according to ISO 21501-4 and IEC 61010-2-020 safety standards, the CL8R employs horizontal rotor architecture with active refrigeration (–20 °C to +40 °C range) to maintain sample integrity during prolonged high-capacity runs. Its core mechanical design follows Couette-flow principles optimized for low-shear sedimentation of fragile biological macromolecules—including plasmids, viral vectors, exosomes, and cell lysates—while minimizing thermal drift and mechanical stress. The system integrates a brushless DC motor with closed-loop speed control, enabling precise rotational stability (< ±10 rpm at 8,000 rpm) under full-load conditions. All structural components undergo MCA (Maximum Credible Accident) testing per EN 61010-1 Annex BB, validating containment integrity under worst-case rotor failure scenarios.
Key Features
- Ultra-High Sample Throughput: Supports up to 6 × 2400 mL centrifuge bottles (14.4 L total) or optional 8 × 2200 mL configuration (17.6 L), enabling single-run processing of bulk fermentation harvests or plasma batches.
- Carbon-Fiber Horizontal Rotors: First domestically certified carbon-fiber rotor system (validated to >100,000 cycles), offering 32% weight reduction vs. aluminum equivalents, enabling faster acceleration (0–8,000 rpm in ≤90 s) and enhanced chemical resistance to organic solvents and caustic cleaning agents.
- Intelligent Safety Architecture: Dual-layer protection includes automatic rotor ID recognition via RFID tags, real-time imbalance detection (< 5 g mass differential), door interlock with anti-pinch sensors, and fail-safe compressor shutdown upon lid opening.
- Energy-Efficient Thermal Management: Dynamic refrigeration control modulates compressor output based on real-time chamber load and ambient temperature; standby mode reduces power consumption by 68% during idle periods.
- Modular Control Interface: 10.1-inch capacitive touchscreen with multilingual OS (English/Chinese), programmable quick-access buttons, and direct RCF/rpm conversion toggle without parameter re-entry.
- Expandable Data Infrastructure: Standard Ethernet (TCP/IP) port compliant with Modbus TCP protocol; provides access to 42 real-time process variables (e.g., actual RCF, chamber ΔT, motor current, rotor cycle count) for integration into MES/LIMS environments.
Sample Compatibility & Compliance
The CL8R accommodates industry-standard disposable and reusable containers—including Corning® 2400 mL bottles, Thermo Fisher Nunc™ CryoPlus™ bags (up to 2 L), and custom stainless-steel canisters—via interchangeable horizontal rotor carriers. All rotors are certified to ISO 15522:2020 for fatigue life validation and comply with ASTM F2119-22 for mechanical shock resistance. The 316L stainless-steel centrifuge chamber (2 mm thickness, passivated per ASTM A967) ensures corrosion resistance against 1 N NaOH, 30% H2O2, and ethanol-based disinfectants. Structural frame components (Q235 steel, ≥2.5 mm thickness) meet CE machinery directive 2006/42/EC requirements. Full audit trail functionality—including user login history, parameter change logs, and alarm event timestamps—is available to support FDA 21 CFR Part 11 and EU Annex 11 compliance when paired with optional离心机管理系统 (Centrifuge Management System).
Software & Data Management
Embedded firmware supports GLP/GMP-aligned data handling: all runs generate timestamped .CSV files containing setpoints, actual values, alarms, and environmental metadata. Optional Centrifuge Management System (CMS) enables centralized monitoring of up to 100 units via secure TLS 1.2 connection; features include remote start/stop, live parameter streaming, predictive maintenance alerts (based on cumulative rotor revolutions and thermal cycling history), and automated report generation compliant with ISO/IEC 17025 clause 7.8. Audit logs are write-once/read-many (WORM) and digitally signed to prevent tampering. CMS API documentation and register mapping tables are provided for third-party SCADA integration.
Applications
- Large-volume clarification of mammalian cell culture harvests (mAb, recombinant proteins)
- Downstream processing of lentiviral and AAV vectors in gene therapy manufacturing
- Blood bank operations: platelet-rich plasma (PRP), cryoprecipitate, and red blood cell fractionation
- Industrial-scale enzyme recovery from microbial fermentations
- Environmental sample concentration (e.g., wastewater microplastics, algae harvesting)
- Preparative isolation of extracellular vesicles (EVs) and lipoprotein subfractions
FAQ
What is the maximum allowable imbalance tolerance during operation?
The CL8R detects mass imbalances exceeding 5 g across opposing buckets and halts acceleration before reaching set speed. Imbalance correction requires manual repositioning or weight adjustment prior to restart.
Is rotor lifetime tracking automated?
Yes. Each carbon-fiber rotor contains an embedded RFID tag storing serial number, manufacture date, and cumulative run cycles. The system enforces hard stop at 100,000 cycles and displays remaining life percentage on the main interface.
Can the centrifuge operate without refrigeration?
Yes. The unit supports ambient-mode operation (compressor disabled) with chamber temperature passively regulated by convection cooling. Temperature setpoint range remains active but defaults to “Off” when refrigeration is deselected.
Does the system support 21 CFR Part 11 electronic signatures?
Electronic signature capability requires CMS license activation and external identity provider (LDAP/Active Directory) integration. Audit trails meet Part 11 requirements for record retention, authenticity verification, and role-based access control.
What certifications are included with shipment?
Each unit ships with Factory Acceptance Test (FAT) report, MCA test certificate (TÜV SÜD accredited), material traceability documents for 316L chamber and Q235 frame, and ISO 9001:2015-compliant calibration certificates for speed and temperature sensors.
