Xiangyi DL-5M Low-Speed Refrigerated Centrifuge

Overview

The Xiangyi DL-5M is a floor-standing, low-speed refrigerated centrifuge engineered for high-capacity, temperature-controlled separation of biological and industrial suspensions. Designed according to the principles of sedimentation centrifugation under controlled thermal conditions, it operates within a validated temperature range of −20 °C to +40 °C—enabling consistent isolation of large subcellular particles, organelles, viruses, and precipitated macromolecules without thermal denaturation or aggregation. Its robust architecture supports routine use in water treatment facilities, biopharmaceutical manufacturing, blood product processing, and academic life science laboratories where reproducible, GMP-aligned sample preparation is essential. The unit integrates a high-efficiency R404A refrigeration system with precise PID-based temperature regulation (±1 °C), ensuring thermal stability across extended runs—even at maximum load.

Key Features

• Brushless AC frequency-controlled motor delivering high torque, zero carbon brush wear, and extended service life—eliminating particulate contamination risks common in brushed systems.
• Intuitive touchscreen interface with digital RPM/RCF/time display and full programmability—including user-defined protocols, recallable methods, and real-time parameter monitoring.
• Advanced deceleration control with 10 selectable braking profiles (including free-coast mode) and 9 acceleration ramps—optimized to minimize sample resuspension and maximize pelleting integrity.
• Dual-stage damping suspension combined with precision-balanced rotor assemblies ensures vibration suppression below ISO 10816-3 Class A thresholds, even at full 4 × 750 mL capacity.
• Comprehensive safety architecture: lid interlock with force-sensing mechanism, mechanical rotor identification, overspeed cutoff, real-time motor fault detection (inverter diagnostics), and triple-layer reinforced housing conforming to IEC 61010-2-020 requirements.
• Stainless-steel interior chamber rated for corrosion resistance per ASTM A240 Type 304 specifications; fully drainable, seamless design compatible with routine decontamination and cleaning validation procedures.

Sample Compatibility & Compliance

The DL-5M accommodates a broad spectrum of sample formats through its modular rotor ecosystem—including fixed-angle, horizontal, microplate, and specialized carriers for radioimmunoassay tubes, vacuum blood collection tubes, and environmental water samples. Certified rotors support capacities up to 4 × 750 mL (e.g., No.4 horizontal rotor) and achieve up to 3660 ×g at 4000 rpm—sufficient for pelleting mitochondria, lysosomes, and enveloped viruses per ISO 15189 Annex B and USP sedimentation guidelines. All rotors undergo static and dynamic balancing verification per ISO 1940-1 Grade G2.5. The system complies with electromagnetic compatibility (EMC) standards EN 61326-1 and electrical safety standard EN 61010-1, and supports audit-ready operation in GLP/GMP environments via optional event-log export (timestamped, non-editable).

Software & Data Management

While the DL-5M operates via embedded firmware without external PC dependency, its control system maintains an internal audit trail of all executed runs—including date/time stamp, rotor ID, set parameters, actual RCF, final temperature, and anomaly flags (e.g., imbalance alert, temp deviation). Logs are exportable via USB to CSV format for integration into LIMS or electronic lab notebooks. Optional firmware upgrade enables 21 CFR Part 11-compliant user authentication (role-based access), electronic signatures, and immutable run records—meeting FDA-regulated QC/QA documentation requirements for pharmaceutical process development and release testing.

Applications

• Large-volume clarification of fermentation broths and cell lysates in upstream bioprocessing.
• Isolation of erythrocytes, leukocytes, and platelet concentrates from whole blood—validated per AABB Technical Manual Chapter 5 protocols.
• Sedimentation of activated sludge flocs and algal biomass in municipal and industrial wastewater characterization (ASTM D5905-22).
• Preparative separation of plant organelles (chloroplasts, nuclei) and viral vectors in vaccine R&D workflows.
• Temperature-stable fractionation of heat-labile enzymes and coagulation factors during diagnostic reagent manufacturing.

FAQ

What is the maximum relative centrifugal force (RCF) achievable with the DL-5M, and at what speed?

The DL-5M achieves a maximum RCF of 3660 ×g at 4000 rpm using the No.6 horizontal rotor (4 × 250 mL). At its top speed of 5000 rpm, the No.1 fixed-angle rotor delivers 2687 ×g.
Does the DL-5M support rotor auto-recognition or barcode scanning?

No. Rotor identification is performed mechanically via keyed inserts and position-coded lugs—ensuring correct speed/RCF limits are enforced without software dependency.
Can this centrifuge be integrated into a networked laboratory data system?

Yes—via USB export of timestamped run logs in CSV format. For Ethernet or LIS connectivity, third-party middleware solutions may be deployed under validated IT infrastructure protocols.
Is the R404A refrigerant compliant with current EU F-Gas Regulation (EU) No 517/2014?

R404A has a GWP of 3922 and is subject to phase-down under EU F-Gas rules. While permissible for existing equipment servicing, new installations in the EU typically require alternatives such as R448A or R449A. Customers should consult local regulatory guidance prior to procurement.
What maintenance intervals are recommended for the refrigeration system and drive motor?

Compressor oil and refrigerant charge require verification every 24 months; motor bearings are sealed-for-life with no scheduled lubrication. Full preventive maintenance—including calibration of temperature and speed sensors—is recommended annually per ISO/IEC 17025 Clause 6.4.3.