YiHeng LRH-Series Large-Scale Biochemical Incubator with Multi-Stage Programmable LCD Controller

Overview

The YiHeng LRH-Series Large-Scale Biochemical Incubators are engineered for precision-controlled, long-duration biological and environmental incubation tasks in regulated laboratory environments. Designed around a dual-mode air-jacketed heating system and compressor-based refrigeration architecture, these incubators maintain stable thermal conditions across wide operating ranges—from sub-zero preservation to elevated enzymatic or microbial growth temperatures. Their core operational principle relies on PID-controlled thermal regulation combined with adaptive fan-speed modulation to minimize thermal gradients and mechanical stress on sensitive biological samples. Unlike basic static incubators, the LRH-Series integrates programmable multi-stage temperature profiles, enabling users to replicate dynamic physiological or environmental temperature cycles—critical for BOD assays, microbial strain adaptation studies, plant tissue culture acclimatization, and pharmaceutical stability testing under ICH Q1 guidelines.

Key Features

• Mirror-finish stainless-steel interior chamber with radius-corner design ensures seamless cleaning, corrosion resistance, and compliance with ISO 14644-1 Class 7 cleanroom-compatible maintenance protocols.
• High-efficiency hermetic compressor with R134a refrigerant delivers consistent cooling performance down to −10°C while meeting international energy efficiency standards (IEC 60068-3-5).
• Microprocessor-based PID temperature controller with real-time digital display offers ±0.1°C setpoint resolution and supports up to 30 programmable segments per cycle—each configurable for temperature, ramp rate, dwell time (1–5999 minutes), and fan speed priority.
• Dual independent safety systems: hardware-based overtemperature cutoff (adjustable limit switch) and software-monitored deviation alarm (±3°C threshold), both triggering audible/visual alerts and automatic power interruption per EN 61000-6-2 EMC and IEC 61010-1 safety requirements.
• Intelligent airflow management: variable-speed centrifugal fan automatically reduces rotational speed during thermal stabilization phases to suppress convective drying of agar plates, suspension cultures, and explants—reducing evaporation loss by up to 40% compared to fixed-speed alternatives.
• Standard RS485 Modbus RTU interface and optional USB data export (via FAT32-formatted USB flash drive) support GLP-compliant audit trails, including timestamped temperature logs, alarm events, and program execution history.

Sample Compatibility & Compliance

The LRH-Series accommodates standard microbiological vessels—including Petri dishes (up to 150 mm), test tubes (16 × 150 mm), Erlenmeyer flasks (up to 2 L), and multi-well plates—within its adjustable shelf configuration (5-position rack system, 70 mm vertical increment). Internal volume options (800 L, 1000 L, 1500 L) meet ASTM E171-22 requirements for large-chamber environmental simulation equipment. The incubators are validated for use in laboratories adhering to CLSI M22-A3, USP , and ISO 20387:2018 biobanking infrastructure specifications. All models undergo factory calibration traceable to NIM (National Institute of Metrology, China) standards, with optional IQ/OQ documentation packages available for GMP-regulated facilities.

Software & Data Management

The built-in LCD controller supports direct parameter entry without external software. For advanced integration, the optional PC software (YiHeng LabLink v3.2) enables remote monitoring, multi-unit synchronization, and automated report generation compliant with FDA 21 CFR Part 11 Annex 11 requirements—including electronic signatures, user-level access control, and immutable audit logs. Data export formats include CSV (for Excel/LabChart analysis) and PDF (for SOP-aligned record archiving). USB logging captures continuous 1-second interval temperature readings for ≥30 days per session—sufficient for full-cycle BOD5 validation or 21-day OECD 209 biodegradability assays.

Applications

• Environmental testing: Wastewater BOD₅ determination (APHA 5210B), algal growth inhibition assays (OECD 201), and sediment toxicity screening.
• Microbiology & virology: Aerobic/anaerobic bacterial culture (ISO 4833-1), fungal isolation (ISO 21527-1), and phage propagation under controlled thermal ramps.
• Pharmaceutical QC: Stability testing per ICH Q5C (cell line storage), excipient compatibility studies, and lyophilized product reconstitution kinetics.
• Agricultural research: Seed germination profiling across diurnal temperature cycles, callus induction in tissue culture media, and rhizobial symbiosis assays.
• Academic teaching labs: Multi-week student projects requiring unattended operation, such as yeast fermentation kinetics or antibiotic resistance evolution experiments.

FAQ

What is the maximum allowable ambient temperature for continuous operation?
The unit is rated for ambient conditions up to 30°C (86°F) at 60% RH, per IEC 60068-2-14. Operation above this requires derating of low-temperature capability.
Can the incubator be validated for GxP environments?
Yes—factory-installed sensors are calibrated to ±0.3°C accuracy (NIST-traceable certificate included); IQ/OQ/PQ protocols and 3Q documentation templates are available upon request.
Is CO₂ or humidity control available as an option?
No—this model is strictly temperature-controlled. For CO₂/humidity applications, refer to YiHeng’s HERAcell series incubators.
How is temperature uniformity verified during installation qualification?
A 9-point mapping protocol (per ISO 14644-3 Annex B) using calibrated PT100 probes is recommended; deviation must remain within ±2.5°C at 25°C nominal setpoint.
Does the RS485 interface support Modbus TCP/IP conversion?
Yes—when paired with a third-party industrial gateway (e.g., Moxa EDS-205A), the native Modbus RTU port enables Ethernet-based SCADA integration.