Sartorius Biotrate Bottle-Top Digital Titrator LH-723080

Overview

The Sartorius Biotrate Bottle-Top Digital Titrator LH-723080 is an engineered solution for precise, repeatable, and operator-friendly manual titrations in regulated laboratory environments. Unlike conventional burettes or standalone potentiometric titrators, the LH-723080 integrates digital volumetric dispensing with electrochemical endpoint detection—operating on the principle of potentiometric titration, where potential change across a reference/indicator electrode pair signals stoichiometric equivalence. Designed as a universal potentiometric titrator, it supports acid-base, redox, precipitation, and complexometric titrations without requiring reconfiguration of hardware. Its bottle-top architecture eliminates syringe-based fluid handling errors and reduces contamination risk by maintaining closed-system integrity from reagent reservoir to tip. The device complies with ISO 8655-3 (volumetric dispensers) and supports traceability requirements aligned with GLP and GMP practices through calibrated volume delivery and documented performance verification.

Key Features

• 360° rotatable dispensing head: Enables ergonomic positioning without rotating the reagent bottle or entire unit—maintains optimal alignment of display, control dial, and label orientation.
• Integrated media recirculation system: Returns unused titrant to the original bottle during priming or partial dispensing, minimizing reagent waste and ensuring consistent concentration throughout use.
• Autoclavable liquid path: All wetted components—including piston, cylinder, valves, and tubing—are constructed from chemically inert materials (PTFE, FEP, PEEK, and borosilicate glass) and withstand standard autoclave cycles (121°C, 20 min, saturated steam), supporting sterile applications in pharmaceutical QC and bioprocessing labs.
• UV-protective amber window: Interchangeable amber front panel shields light-sensitive titrants (e.g., iodine, silver nitrate, ceric sulfate) from photodegradation, preserving reagent stability and assay validity.
• Luer-lock interface for desiccant tubes and inline filters: Located at the rear housing, this port allows integration of moisture-scavenging or particulate filtration systems—critical for hygroscopic or suspension-based titrants.
• Digital precision mechanics: A low-friction ceramic-coated piston driven by micro-stepped motor ensures smooth, pulse-free delivery with ≤±0.2% volumetric accuracy and 0.001 mL resolution across the full 0.1–5 mL operating range.

Sample Compatibility & Compliance

The LH-723080 accommodates a broad spectrum of titrants and analytes, including strong acids (HCl, H₂SO₄), bases (NaOH, KOH), oxidizing agents (KMnO₄, K₂Cr₂O₇), chelating reagents (EDTA), and halide solutions (AgNO₃). Its high chemical resistance enables direct dispensing of solvents such as acetone, methanol, acetonitrile, and chlorinated hydrocarbons without degradation of seals or internal surfaces. The instrument meets ISO 8655-3 for gravimetric performance validation and supports audit-ready documentation per FDA 21 CFR Part 11 when interfaced with compliant LIMS or ELN platforms. It is routinely validated in accordance with USP , EP 2.2.43, and ASTM E2060 for volumetric accuracy in quality control laboratories.

Software & Data Management

While the LH-723080 operates as a standalone digital titrator with integrated LCD display and tactile rotary encoder, it features RS-232 and optional USB connectivity for bidirectional communication with external software. Compatible with Sartorius LabX® Lite (free edition) and third-party titration data managers, it exports timestamped dispense logs—including volume, direction, speed, and error flags—to CSV or XML formats. Audit trail functionality records all parameter changes, calibration events, and user logins—supporting ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available). Data encryption and electronic signature workflows are enabled via LabX Enterprise integration.

Applications

• Pharmaceutical QC: Assay of active pharmaceutical ingredients (APIs), residual solvent quantification, and excipient purity testing per ICH Q2(R2) guidelines.
• Food & Beverage: Total acidity (TA), salt content (via argentometric titration), and vitamin C (ascorbic acid) determination using iodometric methods.
• Environmental Testing: Chloride, hardness (Ca²⁺/Mg²⁺), and alkalinity measurements in wastewater and drinking water per EPA Methods 310.1 and 315.0.
• Academic Research: Teaching quantitative analysis techniques with real-time endpoint visualization and reproducible sub-milliliter dosing.
• Chemical Manufacturing: In-process control of neutralization reactions, catalyst activity assessment, and batch release testing.

FAQ

Is the LH-723080 suitable for use with non-aqueous titrants?
Yes—the chemically resistant fluid path (FEP/PTFE/PFA seals, glass cylinder) supports common non-aqueous solvents including glacial acetic acid, dimethylformamide (DMF), and propylene carbonate.
Can the device be calibrated in-house?
Yes—gravimetric calibration is performed using certified weights and distilled water or standard solutions, following ISO 8655-6 procedures; calibration certificates are generated and stored internally.
Does it support GLP-compliant electronic record keeping?
When connected to LabX or validated third-party software, it provides full audit trails, user access controls, and electronic signatures meeting GLP and 21 CFR Part 11 requirements.
What maintenance is required for long-term accuracy?
Routine cleaning with compatible solvents, annual verification of piston seal integrity, and biannual gravimetric accuracy checks are recommended per Sartorius Technical Bulletin TB-LH-002.
Is the amber window removable for cleaning or replacement?
Yes—the UV-protective acrylic window is tool-free and snap-fits into the front housing; spare windows are available as consumable part #LH-AMBER-WIN.