CZGY FK-A Tissue Homogenizer

Overview

The CZGY FK-A Tissue Homogenizer is a benchtop high-speed rotational homogenization system engineered for consistent mechanical disruption of soft biological and semi-soft laboratory samples. It operates on the principle of high-shear rotor-stator interaction: a precision-machined stainless-steel blade assembly rotates at controlled speeds (10,000–12,000 rpm), generating intense hydrodynamic forces within the sample matrix to achieve rapid cellular lysis, tissue dissociation, or particle size reduction. Designed for routine use in life science research, clinical diagnostics, food science, and pharmaceutical development labs, the FK-A delivers reproducible homogenization performance without requiring cryogenic treatment or chemical additives—making it suitable for downstream applications including RNA/DNA extraction, protein solubilization, enzyme activity assays, and nutrient analysis.

Key Features

• Robust 200 W induction motor with thermally protected windings for stable operation under intermittent load cycles
• Stainless-steel grinding chamber (1000 mL capacity) with integrated sealing gasket and ergonomic rubber lid for leak-resistant containment
• Direct-coupled drive mechanism via elastic coupling joint ensures precise alignment between motor shaft and blade spindle, minimizing vibration and mechanical wear
• Two-stage speed control interface enabling gradual ramp-up from low to high shear conditions—critical for preserving labile biomolecules
• Optimized blade geometry and chamber geometry promote turbulent flow patterns that enhance mixing efficiency and reduce processing time
• Compact footprint (48 × 33 × 23 cm) and lightweight design (7.5 kg) facilitate placement on standard laboratory benches or mobile carts
• Compliance-ready construction: all wetted parts are non-porous, autoclavable stainless steel (AISI 304 grade), supporting GLP-aligned cleaning validation protocols

Sample Compatibility & Compliance

The FK-A is validated for use with soft-to-medium consistency samples including animal tissues (liver, spleen, muscle), plant leaves and roots, cultured cells in suspension, soft fruits, dairy emulsions, and polymer gels. It is not intended for hard, fibrous, or highly viscous materials such as bone, cartilage, stone, or concentrated pastes (e.g., starch gels >15% w/w). Input particle size must be ≤15 mm to ensure uniform feed and prevent blade jamming. Final particle distribution falls within the 0.01–0.5 mm range under standard operating conditions (10,000 rpm, 90-second cycle), verified using laser diffraction particle sizing per ISO 13320. The unit meets IEC 61000-6-2 (EMC immunity) and IEC 61000-6-3 (EMC emission) standards. Electrical safety complies with GB 4793.1–2019 (equivalent to IEC 61010-1), ensuring safe operation in Class II laboratory environments.

Software & Data Management

The FK-A is a manually operated analog device with no embedded microprocessor or digital interface. All operational parameters—including speed selection, run duration, and duty cycling—are set and monitored by the user. For laboratories requiring audit trails and electronic recordkeeping, integration with external timers, programmable power controllers, or laboratory information management systems (LIMS) is supported via standard 220 V AC output sockets and mechanical relay triggers. While the unit itself does not generate digital logs, its mechanical simplicity supports full traceability under FDA 21 CFR Part 11 when used in conjunction with paper-based SOPs and manual logbooks documenting batch number, operator ID, start/stop time, and visual inspection outcomes.

Applications

• Pre-analytical sample preparation for molecular biology workflows (e.g., homogenization prior to column-based nucleic acid isolation)
• Routine quality control testing in food manufacturing—homogenizing meat products, dairy blends, or fruit pulps for compositional analysis
• Pharmaceutical excipient dispersion studies and formulation development for oral suspensions and topical gels
• Nutritional research involving micronutrient release profiling from fortified cereals or functional foods
• Microbiology: preparation of uniform bacterial or fungal suspensions for colony-forming unit (CFU) enumeration
• Environmental monitoring: homogenization of soil cores or sediment samples for heavy metal leaching assays

FAQ

What types of samples are incompatible with the FK-A homogenizer?
Samples with high viscosity (>5000 mPa·s), extreme hardness (e.g., bone, seeds with lignified coats), or excessive fiber content (e.g., mature stems, tendons) may cause blade stall, overheating, or inconsistent particle distribution.
Is the stainless-steel chamber autoclavable?
Yes—the entire grinding chamber, lid, and blade assembly are constructed from AISI 304 stainless steel and withstand standard autoclave cycles (121 °C, 15 psi, 20 min) without dimensional distortion or surface corrosion.
What is the recommended duty cycle to ensure motor longevity?
Continuous operation at maximum speed (12,000 rpm) is limited to 3 minutes, followed by a mandatory 5-minute cooling interval. For extended processing, use medium speed (≈8,000 rpm) with ≤5-minute runs and 2-minute pauses.
Can the FK-A be used for sterile processing?
Sterility depends on pre-sterilization of components and aseptic handling procedures. The unit itself has no built-in sterilization function, but its smooth, crevice-free surfaces support validated cleaning and steam sterilization protocols.
Does the FK-A comply with international regulatory requirements for GMP environments?
While the device lacks digital data logging, its mechanical design, material certification, and cleanability meet baseline equipment qualification criteria for GMP Annex 15 (DQ/IQ/OQ) when accompanied by documented risk assessments and maintenance records.