Anyan AYAN-35L1 Membrane-Based Nitrogen Generator for LC-MS
| Brand | Anyan |
|---|---|
| Origin | Zhejiang, China |
| Manufacturer Type | Authorized Distributor |
| Category | Domestic |
| Model | AYAN-35L1 |
| Nitrogen Generation Principle | Membrane Separation |
| Output Flow Rate | 35 L/min |
| Output Pressure | 0–105 psi (adjustable) |
| Nitrogen Purity | 99.9% |
| Dew Point | −40 °C |
| Filtration | Three-stage filtration (particulates < 0.01 µm |
| Integrated Air Compressor | Yes |
| Noise Level | ≤55 dB(A) |
| Startup Time | ≤3 min |
| Display | Real-time nitrogen purity and pressure readout |
Overview
The Anyan AYAN-35L1 is a compact, integrated membrane-based nitrogen generator engineered specifically for liquid chromatography–mass spectrometry (LC-MS) applications requiring continuous, high-purity nitrogen gas. It employs asymmetric hollow-fiber polymeric membranes—sourced from South Korea—to separate nitrogen from compressed ambient air via selective permeation. In this process, oxygen, water vapor, and carbon dioxide exhibit higher diffusion coefficients and solubility in the membrane polymer than nitrogen, enabling their preferential permeation through the fiber wall under controlled pressure differential. The retained retentate stream delivers nitrogen at ≥99.9% purity (v/v), with a dew point of −40 °C, meeting the stringent moisture and hydrocarbon specifications required for electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) sources. Unlike pressure swing adsorption (PSA) systems, the AYAN-35L1 operates without cycling valves or adsorbent beds, eliminating stepwise pressure transients and ensuring stable, pulse-free gas delivery critical for baseline stability in high-sensitivity MS detection.
Key Features
- South Korean-sourced high-selectivity hollow-fiber membrane modules with validated longevity (>15,000 operating hours under rated conditions)
- Integrated oil-free scroll air compressor with suspended acoustic isolation housing (noise ≤55 dB[A] at 1 m)
- Three-stage pre-compression filtration: particulate (≤0.01 µm), coalescing (oil aerosol <0.003 mg/m³), and activated carbon polishing
- Dual independent pressure regulation: upstream compression pressure control and downstream delivery pressure fine-tuning (0–105 psi range)
- Real-time digital display showing nitrogen purity (%N₂), outlet pressure (psi), and system status indicators
- No consumables beyond standard filter elements; membrane core requires no periodic replacement under normal operation
- Modular design supports seamless capacity expansion—additional membrane stacks can be added without system redesign or downtime
Sample Compatibility & Compliance
The AYAN-35L1 delivers nitrogen meeting ISO 8573-1:2010 Class 2:2:2 specifications for compressed air quality (equivalent to Class 2 for particles, Class 2 for water, Class 2 for oil). Its −40 °C pressure dew point satisfies ASTM D6304 and USP <467> requirements for residual solvent analysis support gases. While not certified to FDA 21 CFR Part 11 out-of-the-box, its digital logging interface supports integration into validated laboratory environments when paired with compliant LIMS or ELN platforms. The unit complies with IEC 61000-6-3 (EMC emission) and IEC 61000-6-2 (immunity) standards. All internal wetted materials—including stainless-steel tubing, EPDM seals, and food-grade anodized aluminum housings—are compatible with LC-MS mobile phase vapors and non-reactive toward common organic solvents.
Software & Data Management
The AYAN-35L1 features embedded microcontroller firmware with non-volatile memory for runtime logging (total operating hours, cumulative flow, alarm history). Data export is supported via RS-232 serial port (ASCII protocol) for integration into facility-wide gas monitoring dashboards. Optional analog 4–20 mA outputs are available for remote pressure and purity signal transmission to PLC or SCADA systems. Audit trail functionality—including timestamped parameter changes and fault event records—is configurable per GLP/GMP-aligned SOPs. Firmware updates are performed via secure USB interface with cryptographic signature verification to ensure traceability and integrity.
Applications
- LC-MS nebulizer and desolvation gas supply (ESI/APCI sources)
- GC-MS make-up gas and carrier gas backup (for helium-scarce environments)
- NMR solvent degassing and sample purging
- Inert atmosphere maintenance in glove boxes and synthesis reactors
- Blanketing and headspace purging in stability chambers and accelerated degradation studies
- Calibration gas dilution systems requiring stable, low-moisture nitrogen matrix
FAQ
What is the typical startup time to reach full-rated flow and specified purity?
The system achieves stable 99.9% nitrogen output within ≤3 minutes of power-on, with pressure ramping to setpoint in under 90 seconds.
Does the unit require external compressed air?
No—it integrates a maintenance-free oil-free scroll compressor; no external air source is needed.
How often must filters be replaced?
Pre-filter cartridges require replacement every 2,000 hours or annually, whichever occurs first; final polishing carbon filter every 4,000 hours.
Can the AYAN-35L1 be used in a Class 100 cleanroom environment?
Yes—its sealed enclosure, zero oil carryover, and particle-filtered output meet ISO 14644-1 Class 5 (Class 100) airborne particulate limits when installed with appropriate venting and grounding.
Is remote monitoring supported?
Yes—via RS-232 ASCII protocol or optional 4–20 mA analog outputs; Modbus RTU integration is available upon request.
What safety certifications does the unit hold?
CE marking per Machinery Directive 2006/42/EC and Low Voltage Directive 2014/35/EU; RoHS 2011/65/EU compliant.
