YAMATO RE801 Advanced Rotary Evaporator

Overview

The YAMATO RE801 Advanced Rotary Evaporator is an engineered solution for precise, repeatable solvent removal under reduced pressure in research, QC, and pilot-scale synthesis laboratories. Built upon Couette-flow evaporation principles, it integrates high-fidelity vacuum regulation, digitally controlled rotation, and intelligent thermal coordination between the rotating flask and heating bath. Its design prioritizes operational safety, spatial efficiency, and compliance-ready functionality—enabling reproducible concentration, crystallization, and purification workflows across organic, pharmaceutical, and natural product chemistry applications. The unit operates within a universal voltage range (100–240 V AC), eliminating regional power infrastructure constraints and supporting seamless deployment in global lab environments.

Key Features

• Brushless DC motor drive with closed-loop feedback control ensures stable rotational performance across the full 20–250 rpm range—including low-speed viscous sample handling and high-speed volatile solvent recovery.
• Motorized vertical lift mechanism (130 mm travel) with automatic upward retraction during power failure—preventing condensate backflow and protecting samples and glassware.
• Digital vacuum regulation system with 1 hPa resolution, adjustable hysteresis (1–50 hPa), and real-time vacuum monitoring (0–1033 hPa) for process-critical control of boiling point depression.
• Vapor temperature sensing with dual-resolution display (0.1 °C or 1 °C selectable), enabling accurate tracking of distillate phase behavior without direct contact with the vapor stream.
• Integrated solvent database containing preloaded saturation vapor pressure curves for 53 common solvents—supporting automated parameter initialization and thermodynamic consistency checks.
• Five distinct operating modes: Free Run, Custom Run, Constant-Value Timed Run, Ratio Run (ramp-based), and two Auto Runs (Auto I for drying; Auto II for single-solvent distillation)—each storing up to 10 user-defined protocols.
• Compact footprint (W828 × D400 × H727 mm, max H857 mm with lift extended) optimized for installation inside standard fume hoods—reducing lab space requirements while maintaining full operational accessibility.

Sample Compatibility & Compliance

The RE801 accommodates standard 1 L round-bottom flasks (with optional B/C glass assemblies reducing width to 643 mm) and supports a broad range of solvents—from low-boiling diethyl ether (bp 34.6 °C) to high-boiling dimethyl sulfoxide (bp 189 °C)—via its adaptive vacuum and temperature coordination logic. Its architecture aligns with GLP and GMP documentation expectations: all run parameters (rotation speed, vacuum setpoint, vapor temperature, duration) are digitally recorded and displayed in real time. While the base unit does not include audit-trail logging or electronic signature capability, its deterministic control architecture and hardware-level safety interlocks (e.g., vacuum-triggered bath shutdown, motor overload detection, self-diagnostic vacuum regulator) provide foundational elements for FDA 21 CFR Part 11–aligned system validation when integrated with compliant data acquisition software.

Software & Data Management

The RE801 operates via an embedded microcontroller interface with no external PC dependency. All settings—including rotation, vacuum, timing, and mode selection—are entered and monitored through a front-panel keypad and LCD display. Memory retains 10 protocols per mode (excluding Free Run). Optional cooling water temperature monitoring (via accessory sensor) adds a fourth real-time parameter for heat exchange optimization. Data export is not natively supported; however, the deterministic digital control loop and repeatable mechanical actuation enable high inter-run reproducibility—critical for method transfer and regulatory batch record generation. For laboratories requiring electronic records, third-party analog/digital signal logging (e.g., via 4–20 mA or RS-485 interfaces on compatible bath units) can be implemented at the system integration level.

Applications

• Routine solvent removal following column chromatography or extraction protocols in medicinal chemistry labs.
• Concentration of thermally sensitive natural product isolates (e.g., terpenes, alkaloids) under precisely controlled vacuum and temperature gradients.
• Removal of residual solvents from API intermediates prior to crystallization, in alignment with ICH Q3C guidelines.
• High-throughput sample preparation for GC-MS or LC-MS analysis where consistent final volume and minimal analyte degradation are essential.
• Educational demonstrations of Raoult’s law, Clausius–Clapeyron relationships, and vacuum-phase equilibria in physical chemistry curricula.

FAQ

Does the RE801 support remote operation or computer connectivity?
No—the RE801 is a standalone instrument with local keypad-and-display control. It does not feature USB, Ethernet, or Bluetooth interfaces. Remote monitoring requires external analog signal capture from connected baths or vacuum gauges.
Is the 1 L capacity rated for full-volume operation under vacuum?
Yes—the 1 L flask is designed for safe use at full nominal volume under recommended vacuum and rotation conditions. Optimal performance is achieved when fill volume remains ≤60% of flask capacity to prevent bumping or foaming-induced carryover.
Can the RE801 be used with oil baths above 100 °C?
Yes—its联动 control function supports both water and oil baths. When paired with a compatible YAMATO SB-series oil bath, the system coordinates shutdown and保温 (temperature hold) based on vacuum or timer events, ensuring thermal stability during extended runs.
What safety certifications does the RE801 carry?
The unit complies with IEC 61010-1 (Safety Requirements for Electrical Equipment for Measurement, Control, and Laboratory Use) and bears PSE marking for Japan market compliance. CE marking is not applicable as it is classified as laboratory equipment intended for professional use under Annex II of the EMC Directive.
How is calibration traceability maintained for vacuum and temperature readings?
Vacuum and vapor temperature sensors are factory-calibrated against NIST-traceable references. Users may perform field verification using certified reference gauges and calibrated thermistors; however, end-user adjustment is not supported—calibration adjustments require authorized YAMATO service personnel.