Thermo Fisher TSQ Quantis™ Plus Triple Quadrupole Mass Spectrometer (Rental Unit)

Overview

The Thermo Fisher TSQ Quantis™ Plus Triple Quadrupole Mass Spectrometer is a high-performance, purpose-engineered LC-MS/MS platform designed for robust, high-throughput targeted quantitation and screening in regulated and research-intensive environments. Operating on the fundamental principle of tandem mass spectrometry—where precursor ions are selected in Q1, fragmented in the collision cell (Q2), and product ions are analyzed in Q3—the instrument delivers exceptional specificity, sensitivity, and reproducibility for small molecules, peptides, metabolites, and contaminants. Its architecture integrates advanced ion optics, optimized RF/DC voltage control, and thermally stable vacuum systems to ensure consistent performance across extended acquisition cycles. The TSQ Quantis™ Plus is particularly suited for laboratories requiring regulatory-compliant workflows in pharmaceutical development, environmental monitoring, food safety testing, clinical biomarker validation, and forensic toxicology—where trace-level detection, wide dynamic range, and method transferability are critical operational requirements.

Key Features

• Triple quadrupole mass analyzer with mass range of 2–3000 m/z, enabling broad coverage of small-molecule analytes and post-translational modifications.
• High-speed Selected Reaction Monitoring (SRM) acquisition—optimized for >10,000 transitions per second—supporting large-scale multi-analyte panels and rapid chromatographic methods (e.g., UHPLC gradients ≤2 min).
• Dynamic range exceeding six orders of magnitude, validated under ISO 17025-aligned conditions for reliable quantification from sub-pg/mL to µg/mL concentrations.
• Modular ion source compatibility: supports OptaMax NG electrospray interface, FAIMS Pro Duo differential mobility separator, VeriSpray PaperSpray, EASY-Spray nano-electrospray, and Nanospray Flex sources—enabling method flexibility across sample complexity and matrix type.
• Engineered for uptime: reinforced vacuum architecture with oil-based pumping system ensures long-term stability under continuous operation; mean time between service interventions exceeds 1,500 hours in routine QC labs.
• Backward-compatible method migration path from legacy TSQ Quantis systems—preserving existing method libraries, calibration curves, and instrument qualification documentation.

Sample Compatibility & Compliance

The TSQ Quantis™ Plus accommodates diverse sample types—including plasma, urine, tissue homogenates, water extracts, food digests, and pesticide residues—when coupled with appropriate sample preparation (e.g., protein precipitation, SPE, QuEChERS). It meets key regulatory expectations for analytical instrumentation: data integrity is enforced via audit-trail-enabled software compliant with FDA 21 CFR Part 11 and EU Annex 11; hardware design aligns with IEC 61000-6-3 (EMC) and IEC 61010-1 (safety); and performance verification follows ASTM D7893 (LC-MS/MS method validation) and USP <1225> guidelines. Routine operation supports GLP and GMP environments when deployed with documented IQ/OQ/PQ protocols and electronic lab notebook (ELN) integration.

Software & Data Management

Instrument control and data processing are managed through Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) v7.3 or higher, licensed for rental deployment. The platform includes preconfigured quantitative workflows for common applications (e.g., vitamin D, mycotoxins, β-lactam antibiotics), compound libraries (mzCloud, mzVault), and automated peak integration with customizable decision trees. All raw data files (.raw) are stored in vendor-neutral formats compatible with third-party analysis tools (e.g., Skyline, SimLipid). Audit trails record user actions, parameter changes, and report generation timestamps—fully exportable for internal review or regulatory inspection. Remote monitoring and diagnostic capabilities allow proactive maintenance scheduling without on-site intervention.

Applications

• Pharmaceutical: PK/PD studies, impurity profiling, extractable/leachable analysis, and bioanalytical method validation per ICH M10.
• Environmental: Multi-residue analysis of pesticides, PFAS, pharmaceuticals in wastewater, and dioxin-like compounds in soil/sediment.
• Food Safety: Screening of veterinary drug residues, mycotoxins, allergens, and adulterants per EU Commission Regulation (EU) No 2021/808.
• Clinical Research: Quantitative measurement of hormones, neurotransmitters, therapeutic drugs, and lipid mediators in biological matrices.
• Forensic Toxicology: Confirmation and quantification of opioids, stimulants, synthetic cannabinoids, and novel psychoactive substances in blood and hair.

FAQ

Is the TSQ Quantis™ Plus available for short-term lease only?
Yes—rental terms are configurable from 1 month to 36 months, with options for early termination clauses and flexible delivery scheduling.
Can I upgrade to a newer model during the lease term?
Yes—our “Lease-to-Own” and “Rent-to-Buy” programs include seamless hardware refresh pathways with credit applied toward purchase.
Are software licenses included and transferable?
Full CDS licensing is provided for the lease duration, including updates and security patches; licenses are non-transferable outside the contractual scope.
What level of technical support is covered?
All rentals include remote diagnostics, application consulting, scheduled preventive maintenance, and priority response SLAs—no additional service contract required.
Does the system comply with ISO/IEC 17025 accreditation requirements?
Yes—the instrument’s performance verification package, calibration records, and software audit trail functionality support laboratory accreditation under ISO/IEC 17025:2017 Clause 5.9 and 5.10.