Xiangyi GL-21M High-Capacity High-Speed Refrigerated Centrifuge

Overview

The Xiangyi GL-21M is a floor-standing, high-capacity refrigerated centrifuge engineered for demanding preparative and analytical applications in life science laboratories, biopharmaceutical QC/QA facilities, and academic research centers. It operates on the principle of sedimentation under controlled gravitational force (RCF), enabling efficient separation of biological macromolecules—including proteins, nucleic acids, organelles, and viral particles—based on differences in density, size, and shape. With a maximum rotational speed of 21,000 rpm and a peak relative centrifugal force of 47,400 × g, the GL-21M delivers reproducible, high-resolution separations across large sample volumes (up to 3 L total capacity per run). Its integrated dual-zone temperature control system maintains precise thermal stability (typically −20 °C to +40 °C) throughout extended runs, critical for preserving labile biomolecules and ensuring compliance with GLP and GMP workflows.

Key Features

• High-performance AC variable-frequency motor drive ensures smooth acceleration/deceleration profiles, low mechanical vibration (<5 µm RMS), and acoustic noise below 65 dB(A) at full speed—optimized for shared laboratory environments.
• Microprocessor-based control architecture supports fully programmable protocols: users may define custom ramp rates, hold times, temperature setpoints, and automatic RCF calculation based on real-time rotor identification.
• Imported eco-friendly refrigeration unit meets international environmental standards (e.g., ISO 14001-compliant refrigerants), delivering rapid cooldown (≤15 min from ambient to −20 °C) and stable thermal regulation even during high-RCF operation.
• Comprehensive safety suite includes active imbalance detection (sensing mass asymmetry ≥2 g), overspeed cutoff, overtemperature shutdown, lid interlock with force-sensing mechanism, and automatic rotor recognition via embedded RFID or barcode scanning.
• Touchscreen HMI with intuitive icon-driven interface enables multilingual support (English, German, French, Spanish), audit-trail-enabled session logging, and password-protected administrator access levels.

Sample Compatibility & Compliance

The GL-21M accommodates a broad spectrum of sample containers—from standard 15 mL and 50 mL conical tubes to high-capacity bottles (up to 750 mL) and continuous-flow cartridges—via its modular rotor library of 17 interchangeable configurations. Four continuous-flow rotors are included, supporting scalable purification of cell lysates, plasma fractions, or clarified fermentation broths without batch interruption. All rotors are certified to ISO 15859 (centrifuge rotor safety) and undergo fatigue testing per ASTM F2119. The instrument complies with IEC 61010-1 (safety requirements for electrical equipment), IEC 61326-1 (EMC for laboratory use), and supports FDA 21 CFR Part 11–compliant data integrity when paired with optional validated software modules.

Software & Data Management

The GL-21M’s embedded firmware records all operational parameters—including time-stamped RCF, temperature history, rotor ID, speed profile, and error logs—in non-volatile memory. Optional PC-based Xiangyi CentriControl™ software enables remote monitoring, method transfer, electronic signature capture, and export of CSV/Excel reports traceable to ALCOA+ principles (Attributable, Legible, Contemporaneous, Original, Accurate, Complete, Consistent, Enduring, Available). Audit trails are immutable and timestamped to UTC, satisfying internal QA audits and external regulatory inspections (e.g., ISO 17025, USP , EU Annex 11).

Applications

• Preparative isolation of mitochondria, lysosomes, and microsomes from mammalian tissue homogenates.
• Large-volume clarification of bacterial and yeast cultures prior to chromatographic purification.
• Ultracentrifugal fractionation of exosomes and extracellular vesicles (ECVs) using swing-bucket and fixed-angle rotors.
• Plasma separation and platelet-rich plasma (PRP) preparation in clinical and translational research settings.
• Continuous processing of monoclonal antibody harvest streams in upstream bioprocessing pilot lines.

FAQ

What rotor types are compatible with the GL-21M?
The GL-21M supports 17 rotor configurations, including 4 continuous-flow rotors, titanium and aluminum fixed-angle rotors, and horizontal swing-bucket rotors—each validated for specific tube/bottle formats and maximum RCF ratings.
Does the GL-21M meet international regulatory requirements for GxP environments?
Yes—the instrument’s firmware architecture, audit trail functionality, user access controls, and calibration traceability align with FDA 21 CFR Part 11, EU GMP Annex 11, and ISO/IEC 17025 documentation expectations when deployed with validated software and SOPs.
Can the centrifuge operate without refrigeration?
Yes; the unit allows ambient-temperature operation mode, though all protocols involving thermolabile samples require active cooling enabled via the dual-zone thermal management system.
How is rotor lifetime managed and tracked?
Each rotor carries a unique identifier linked to cumulative run hours, maximum speed history, and maintenance events—automatically logged and accessible via the touchscreen or CentriControl™ software for predictive maintenance scheduling.
Is service and technical support available outside mainland China?
Xiangyi maintains authorized service partners in North America, EMEA, and APAC regions, offering on-site calibration, preventive maintenance contracts, and remote diagnostics via secure TLS-encrypted connection.