SCIEX QTRAP 2000 Hybrid Triple Quadrupole/Linear Ion Trap Mass Spectrometer (Refurbished)
| Brand | SCIEX |
|---|---|
| Origin | USA |
| Model | QTRAP 2000 |
| Instrument Type | Hybrid Triple Quadrupole / Linear Ion Trap Mass Spectrometer |
| Configuration | Standalone MS or LC-MS Compatible (with Shimadzu, Agilent HPLC systems) |
| Operational Age | 3–4 years (Total Service Life: ~7 years) |
| Warranty | 6 months limited hardware warranty |
| Regulatory Compliance | Designed to support GLP/GMP workflows |
Overview
The SCIEX QTRAP 2000 is a hybrid mass spectrometer integrating triple quadrupole (QqQ) scanning capabilities with linear ion trap (LIT) functionality in a single platform. Engineered for quantitative precision and qualitative structural elucidation, it operates on the principle of tandem mass spectrometry (MS/MS) using collision-induced dissociation (CID) in both QqQ and ion trap modes. Unlike conventional single-mode instruments, the QTRAP architecture enables simultaneous acquisition of quantitative multiple reaction monitoring (MRM) data and high-sensitivity information-dependent acquisition (IDA) triggered scans—including enhanced product ion (EPI), neutral loss (NL), and precursor ion (PI) scans—within a single analytical run. This dual-operation capability makes it particularly suitable for laboratories requiring robust bioanalytical quantitation (e.g., pharmacokinetics, clinical toxicology) alongside confirmatory identification tasks without method re-injection. The system was originally manufactured in the United States and has undergone full functional refurbishment and performance verification per SCIEX-recommended protocols.
Key Features
- Hybrid scan architecture: Combines triple quadrupole MRM sensitivity with linear ion trap MSn capability up to MS³
- Dynamic range exceeding 4 orders of magnitude for small-molecule quantitation
- Electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) sources included; source geometry optimized for LC flow rates from 5 µL/min to 1 mL/min
- Ion optics engineered for high transmission efficiency and low chemical noise across mass ranges up to m/z 2000
- Integrated Turbo V™ source with independent heated nebulizer gas control and curtain gas optimization
- Refurbished unit verified for vacuum integrity, detector gain stability, mass calibration accuracy (±0.1 Da), and MRM dwell time reproducibility
Sample Compatibility & Compliance
The QTRAP 2000 interfaces seamlessly with major HPLC platforms including Shimadzu Nexera and Agilent 1260/1290 series systems via standard analog/digital I/O and vendor-neutral LC control protocols. It supports common reversed-phase, HILIC, and ion-pairing chromatographic methods for polar and non-polar analytes. All refurbished units undergo full compliance validation against manufacturer-specified operational thresholds, including detection limit verification using reserpine (S/N ≥ 100:1 at 10 fg on-column) and retention time stability assessment over 24-hour continuous runs. While the instrument itself does not carry FDA certification, its design and firmware architecture are fully compatible with regulated environments: audit trail logging, user access controls, and electronic signature support can be implemented when operated with compliant Chromatography Data Systems (CDS) such as SCIEX OS or third-party 21 CFR Part 11–validated platforms.
Software & Data Management
The system ships with SCIEX Analyst® software v1.6.3 or later (license transferable upon purchase), enabling method development, real-time data acquisition, and post-run processing including peak integration, matrix-matched calibration, and isotopic ratio analysis. Raw data files (.wiff) are natively supported by open-source tools including MSConvert (ProteoWizard) and Skyline for cross-platform quantitation. All refurbished units include validated software installation media, driver packages, and configuration templates aligned with current Windows 10/11 LTSB environments. Data integrity safeguards—including automatic backup of acquisition parameters, timestamped log files, and checksum-verified raw data storage—are enabled by default. Optional upgrades to SCIEX OS provide enhanced metadata tagging, automated QC flagging, and direct LIMS integration via ASTM E1384-compliant interfaces.
Applications
- Bioanalytical method development and validation for small-molecule drugs and metabolites in plasma, urine, and tissue homogenates
- Clinical research applications including therapeutic drug monitoring (TDM), newborn screening metabolite panels, and forensic toxicology screening
- Environmental analysis of pesticides, pharmaceutical residues, and endocrine disruptors in water and soil extracts
- Food safety testing for mycotoxins, veterinary drug residues, and adulterants using multi-residue workflows
- Academic proteomics support for targeted peptide quantitation (SRM/MRM) and PTM characterization via triggered MS³
FAQ
Is this unit eligible for extended warranty or service contracts?
Yes—post-purchase extended service plans (1–3 years) are available through authorized SCIEX-certified field service engineers.
Can the QTRAP 2000 be upgraded to support newer software versions?
Firmware and software compatibility is confirmed up to Analyst 1.7.2; upgrade paths require hardware verification prior to deployment.
What documentation accompanies the refurbished instrument?
Each unit includes a full refurbishment report, pre- and post-verification test logs, calibration certificates traceable to NIST standards, and original OEM user manuals in English.
Are replacement parts and consumables readily available?
All major consumables—including Turbo V source components, ion trap assemblies, and detector housings—are stocked and distributed globally under SCIEX part numbers.
Does the system include installation and qualification support?
Yes—IQ/OQ documentation templates and on-site installation assistance (optional, fee-based) are provided to meet laboratory-specific validation requirements.
